Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.
If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.
Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.
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The Chen Lab studies the transcriptional regulation of nuclear receptors and fusion oncoproteins by using multidisciplinary approaches, while members of the High Throughput Bioscience (HTB) Center (directed by Dr. Chen) work together on target validation, assay development, and compound screening. We investigate signaling pathways and develop chemical probes to modulate transcription, with a goal to understand transcriptional regulation and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models.
The Chen Lab provides a unique training environment: in addition to basic research, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target validation, compound screening to preclinical mechanistic studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities, Senior Scientists in Pharmaceutical Companies, or Staff Scientists at St. Jude.
The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, structural biologists, and technologists. (https://www.stjude.org/chen).
Taosheng Chen, PhD
Member (Professor), Department of Chemical Biology and Therapeutics
St. Jude Graduate School of Biomedical Sciences
Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-2794
Changes in the Structure and Organization of the Genome During Neurogenesis
During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization (https://pecan.stjude.cloud/retinalnucleome). One of the most significant discoveries to come from this comprehensive analysis was the identification of a series of core regulatory circuit super-enhancers (CRC-SEs) adjacent to genes having important roles in retinal development, including Vsx2, Crx, Six3, Otx2, Fgf15, and Ascl1. Each of those CRC-SEs have been deleted in mice using CRISPR-Cas9 and analysis is ongoing. We are also analyzing the evolutionary conservation of those CRC-SEs in human stem cell derived retinal organoids. The results of these studies will be important for filling a fundamental gap in our knowledge about the role of CRC-SEs in retinal development and will set the stage for characterization of CRC-SEs in other genes required for retinogenesis. We are seeking a highly motivated postdoctoral fellow to study the role of CRC-SEs in retinal development and diseases such as macular degeneration and diabetic retinopathy. Training in epigenetics, retinal biology and human stem cell research is preferred.
Michael A. Dyer, Ph.D.
Chair and Member, Developmental Neurobiology Department
Co-leader Developmental Biology and Solid Tumor Program
St. Jude Children’s Research Hospital
A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system and vascular smooth muscle precursors interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) and unpublished data define the existence of this connection in in vertebrates and we are now working to better understand key details. St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources, and a robust community of talented, engaged, and collaborative investigators. We seek an intelligent, friendly, enthusiastic, committed, and capable individual to join our team.
We are particularly seeking an individual with experience in developmental hematopoiesis. In addition to a Ph.D., applicants should have a record of publication, and experience with molecular, biochemical, and cell biological techniques. This position will provide an opportunity for considerable independence and intellectual development, as well as examination of comparative developmental hematopoiesis.
The Clements lab is a friendly group with a keen interest in understanding blood ontogeny and its relationship to malignancy. We support work/life balance and believe that individual happiness is fundamental to scientific discovery and professional fulfillment. Memphis is a vibrant city in the mid-South, with a temperate climate, very active music scene, excellent restaurants, many family-friendly activities, and extremely affordable housing. St Jude Children's Research Hospital offers competitive salary, excellent benefits, and is an equal opportunity employer. Please send a cover letter describing research interests and accomplishments, CV, and the names and addresses of three references to email@example.com.
A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.
Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics and computer science.
St. Jude provides a highly interactive and supportive environment for researchers’ career development.
St. Jude Children's Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, sexual orientation, gender identity, transgender status, age, religion, disability, veteran's status or disabled veteran's status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.
Interested candidates, please complete online application and submit CV to ComputationalBiologyRecruitment@stjude.org.
Postdoctoral Research Associate-Cell Biology of Neural Development
St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.
Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective.
Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration, and polarization.
To apply for this position, submit the online application, and send a C.V. and 3 letters of recommendation to: David J. Solecki, PhD, Department of Structural Biology, Mail Stop 311, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA, firstname.lastname@example.org.