Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

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The Zhou lab in the department of Computational Biology is seeking a postdoctoral trainee who’s passionate about promoting biomedical and cancer research and addressing big data challenges from the unique perspective of scientific data visualization. Dr. Zhou leads a team of bioinformatics scientists and web developers to investigate and implement cutting edge methodologies to utilize multi-omics data in cancer and population science.   The initial appointment will be for 1-2 years and can be renewed for up to a total of 5 years, depending on the candidate’s goals and qualifications.   Interested candidates, please complete the online application and email your CV and cover letter to xin.zhou@stjude.org. Please include areas of specific interest in a brief cover letter.
ID
44920
Department
Computational Biology
Faculty Member
Xin Zhou
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state-of-the-art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.   A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system during viral infection.  We are particularly interested in dissecting the signaling pathways involved in innate immune responses and cell death (NLRs, inflammasomes) in response to viruses.  Please see the following articles: Cell (2021) 184(1)_149-168.e17. Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5. Cell (2015) 162(1):45-58. Nature Immunology (2015) 16(5):467-75. Immunity (2015) 42(4):654-64. Nature (2014) 516(7530):246-9. Nature (2013) 498(7453):224-7.    The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.   Contact Information Thirumala-Devi Kanneganti, PhD Member Department of Immunology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN  38105-3678 E-mail: thirumala-devi.danneganti@stjude.org https://www.stjude.org/kanneganti
ID
44867
Department
Immunology
Faculty Member
Thirumala-Devi Kanneganti
A postdoctoral fellowship position is available for a highly motivated individual interested in the neural circuit mechanisms of schizophrenia. Our laboratory conducts 2-photon laser-scanning microscopy imaging of neuronal activity in awake mice, with a focus on mouse models of 22q11.2 deletion syndrome and 15q11 duplication syndrome, high-risk factors for developing psychiatric disorders, especially schizophrenia and autism, respectively. Preference will be given to applicants who have received their Ph.D. degrees in neuroscience or engineering within the last 3 years and have experience in computational neuroscience and data mining using machine learning methods.   In vivo imaging in awake mice and rats will be performed on 3 dedicated 2-photon microscopes. The fellow will work with a dedicated team of computer scientists. The laboratory also is equipped to perform single-cell electrophysiology, two-photon imaging, and two-photon glutamate uncaging in brain slices.   The fellow will benefit from both an outstanding work environment in the laboratory and a highly collaborative St. Jude community. The successful candidate will join a diverse team of researchers whose efforts are directed toward understanding behavior at the levels of neural circuits, individual neurons, synapses, and molecules. The laboratory is part of the Department of Developmental Neurobiology, which houses specialized departmental shared resources, including an integrated support structure for rodent behavior testing, 3-dimensional brain organoids, in vivo and ex vivo cellular imaging, bioinformatics, production of genetically engineered animal models, single-cell profiling, and advanced image processing and analysis. In addition, numerous institutional shared resources and core facilities support the laboratory by providing expertise and state-of-the-art technologies.         St. Jude Children’s Research Hospital offers an excellent salary and benefits package and is an equal opportunity employer. Interested applicants should send their CVs and the names and addresses of 3 references to: Stanislav Zakharenko, M.D., Ph.D. Department of Developmental Neurobiology, MS 322 St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN 38105 stanislav.zakharenko@stjude.org
ID
44826
Department
Developmental Neurobiology
Faculty Member
Stanislav Zakharenko
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research.    The department is seeking an outstanding postdoctoral fellow to engage in the development of statistical methodology and software for complex biomedical data such as longitudinal, imaging, wearable device, and genetic/genome studies with broad application in pediatric cancer and mental health.     For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine. Salary and benefits are competitive. Apply online and send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.    Appointment is for two years. 
ID
44718
Department
Biostatistics
Faculty Member
Motomi Mori
Postdoctoral Research Associate in Neuroscience / Neurobiology   The Bikoff lab (https://www.bikofflab.org/) is seeking a highly motivated postdoctoral researcher interested in using quantitative approaches to behavior, in vivo calcium imaging, and optogenetics/chemogenetics to study neural circuitry in mice.   We aim to understand the functional organization of neural circuits that control movement, including how descending pathways from the brain interact with spinal circuits to implement motor output. The lab approaches this problem from multiple perspectives, using mouse genetics, single-cell transcriptomics, viral tracing and whole-brain imaging, and animal behavior to explore the role of molecularly discrete subsets of neurons in motor control. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, interactive, and supportive environment that provides the freedom to independently develop a research project.   The Bikoff lab is strongly committed to providing individual mentoring and training for all lab members, as well as additional support for career development.   Applications: Individuals with evidence of scientific accomplishment are encouraged to apply by sending their CV, a brief description of research interests, and contact information for three references to: jay.bikoff@stjude.org.
ID
44720
Department
Developmental Neurobiology
Faculty Member
Jay Bikoff
We are looking for Post-doctoral Research Associate candidates to study protein kinases. The candidate will join an inter-disciplinary Blue Sky initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
ID
44684
Department
Structural Biology
Faculty Member
Charalampos Kalodimos
We are looking for Post-doctoral Research Associate candidates to study protein kinases. The candidate will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
ID
44686
Department
Structural Biology
Faculty Member
Charalampos Kalodimos
We are looking for Post-doctoral Research Associate candidates to study protein kinases. The candidate will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
ID
44687
Department
Structural Biology
Faculty Member
Charalampos Kalodimos
  Epigenetic Characterization and Therapeutic Discovery in Pediatric Brain Tumors   Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021. The ideal candidate will demonstrate a willingness to learn new concepts and technical skills, but most importantly harbor an enthusiasm for working in a team-based environment and interfacing with national and international collaborative efforts. An ideal candidate will have a strong foundation in molecular biology-based techniques, experience/willingness to work with animal handling and procedures, and have a willingness to learn/work with complex computational software. Our ultimate goal in the Mack Lab is to simultaneously advance science of pediatric brain tumors in addition to providing an immersive program that advances the careers of students and research fellows.   St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.
ID
44633
Department
Developmental Neurobiology
Faculty Member
Charlette Hill
  Epigenetic Characterization and Therapeutic Discovery in Pediatric Brain Tumors   Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The basis and funding support for this project is described in our publication Krug et al., Cancer Cell, 2019, Michaelraj et al,. Cell, 2020, and Arabzade et al., Cancer Discovery 2021. The ideal candidate will demonstrate a willingness to learn new concepts and technical skills, but most importantly harbor an enthusiasm for working in a team-based environment and interfacing with national and international collaborative efforts. An ideal candidate will have a strong foundation in molecular biology-based techniques, experience/willingness to work with animal handling and procedures, and have a willingness to learn/work with complex computational software. Our ultimate goal in the Mack Lab is to simultaneously advance science of pediatric brain tumors in addition to providing an immersive program that advances the careers of students and research fellows.   St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.
ID
44634
Department
Developmental Neurobiology
Faculty Member
Charlette Hill
We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children's Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries.  We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors. For more details, please visit https://www.stjude.org/sun or directly contact Dr. Ji Sun (ji.sun@stjude.org).
ID
44434
Department
Structural Biology
Faculty Member
Ji Sun
A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study. St. Jude Children’s Research Hospital is a top-ranked Pediatric Cancer Hospital and a world-renowned basic science research institute with over 200 faculty members. St. Jude offers a highly collaborative research and training environment that includes state-of-the-art facilities and resources. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
44222
Department
Hematology
Faculty Member
Mitchell Weiss
The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer.  The project will include assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.
ID
44212
Department
Immunology
Faculty Member
Benjamin Youngblood
St. Jude Children’s Research Hospital are seeking highly motivated candidates to join the laboratory of Dr. Chia-Hsueh Lee in the Department of Structural Biology as a postdoctoral fellow to lead exciting research initiatives. The lab use cryo-EM and a range of biochemical/biophysical methods to study the function of membrane proteins (e.g. Wang et al., NSMB 2021; Lee and MacKinnon, Cell, 2019; Lee and MacKinnon, Science, 2018).   The lab has frequent access to the state-of-the-art cryoEM facility at St. Jude, which houses a 300kV Titan Krios, a 200kV Arctica, and a 120kV Talos L120C microscope. We are looking for an individual who have a passion for learning and navigating new research fields and is comfortable pursing highly impactful scientific advances.
ID
44202
Department
Structural Biology
Faculty Member
Chia-Hsueh Lee
The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how acquired mutations in hematopoietic stem cells lead to the development of clonal hematopoiesis and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.   You will have the opportunity to develop and lead projects using several cutting-edge model systems including:   - Isogenic immortalized cell lines generated using CRISPR-Cas gene editing - Novel xenograft and transgenic in vivo systems - Primary patient samples   In this position, you will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study development.   St. Jude Children’s Research Hospital is a top-ranked Pediatric Cancer Hospital and a world-renowned basic science research institute with over 200 faculty members. St. Jude offers a highly collaborative research and training environment that includes state-of-the-art facilities and resources. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
44136
Department
Oncology
Faculty Member
Esther Obeng
Postdoctoral Research Associate in Immunology and Immunometabolism in Dr. Hongbo Chi’s Laboratory   Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity. To this end, we apply interdisciplinary strategies by integrating immunological and genetic approaches with cutting-edge systems immunology tools, including single-cell transcriptomics, proteomics, metabolomics, network reconstruction, and in vivo CRISPR screening. Please see the following articles published over the past four years for additional information: Nature 595:724 (2021); Nature 591:306 (2021); Cell 184:1245 (2021); Cell Metabolism 32:996 (2020); Nature Reviews Immunology 20:55 (2020); Nature 565:101 (2019); Nature 576:471 (2019); Immunity 51:1012 (2019); Nature 558:141 (2018); Immunity 49:899 (2018); and Science Immunology aas9818 (2018).   St. Jude Children’s Research Hospital, ranked a best children's hospital for pediatric cancer, offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salary and excellent benefits, to postdoctoral fellows.   Contact Information Hongbo Chi, PhD, Member Department of Immunology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN  38105 https://www.stjude.org/chi
ID
44139
Department
Immunology
Faculty Member
Hongbo Chi
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital.    As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research.   For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.     Salary and benefits are competitive.  Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.        
ID
43885
Department
Biostatistics
Faculty Member
Motomi Mori
St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. We are looking for a candidate to fill any of a number of roles in our highly interdisciplinary, collaborative environment, ranging from single-molecule fluorescence imaging of cells and biomolecules to photophysically-guided development of organic fluorophores. This requires a creative, team-oriented individual with strong leadership skills who is comfortable pursuing highly impactful scientific advances across a range of biological systems and disciplines. Experience with quantitative single-molecule biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. The role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.   Publication links: - Quantifying secondary transport at single-molecule resolution. - Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. - Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. - A partially-open inward-facing intermediate conformation of LeuT is associated with Na<sup>+</sup> release and substrate transport. - Aminoglycoside interactions and impacts on the eukaryotic ribosome. - Dynamics of P-type ATPase transport revealed by single-molecule FRET. - Miscoding-induced stalling of substrate translocation on the bacterial ribosome. - Single-molecule analysis of ligand efficacy in β<sub>2</sub>AR-G-protein activation. - Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging. - Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. - Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation. - Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. - Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. - Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. - Transport domain unlocking sets the uptake rate of an aspartate transporter. - Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. - Ultra-stable organic fluorophores for single-molecule research. - Allosteric control of the ribosome by small-molecule antibiotics. - Cyanine fluorophore derivatives with enhanced photostability. - Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. - Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
ID
43865
Department
Structural Biology
Faculty Member
Roger Altman
The Mefford lab is seeking a postdoctoral fellow in translational neuroscience to study genomic and epigenomic causes of pediatric epilepsy and related disorders. Project opportunities include: integrated analysis of genome and transcriptome data to identify novel causes of pediatric epilepsy; investigating epigenetic causes of epilepsy; and functional studies of genetic epilepsies using patient-derived stem cell models. 
ID
43835
Department
Center for Pediatric Neurological Disease Research
Faculty Member
Heather Mefford
The Geeleher Lab is seeking outstanding candidates for a postdoctoral fellowship focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs. Current research areas - Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics. The postdoc will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications. - Developing statistical methods for integrating single cell and bulk tissue expression data to understand the relationship between common inherited genetic variation, gene expression, and drug response Chemotherapeutic response is a complex trait influenced by numerous factors. Inherited genetic variants influencing gene expression (expression quantitative trait loci, or eQTLs) have been identified as major contributors. However, our recent work has shown that the degree of influence of eQTLs on gene expression in cancer is less well understood than previously thought. The postdoc will explore how inherited genetic variation influences cancer risk, disease progression and drug response, building on methods developed in the lab to deconvolute eQTL signals from bulk tissue expression data to specific cell types. This work will aim to improve our understanding of inherited genetic variation in cancer and yield computational approaches applicable to a broad variety of complex traits and diseases.   About the Geeleher Lab   The lab of Dr. Paul Geeleher is in the Department of Computational Biology at St. Jude Children’s Research Hospital. Dr. Geeleher is recognized for developing innovative computational approaches and has led drug repurposing efforts, spearheaded publications in Nature, Genome Research, Genome Biology, Journal of the National Cancer Institute (JNCI) and Bioinformatics in the last five years and is funded by the NIH. Postdoctoral fellows in the lab will benefit from access to the wealth of high-quality genomics data generated at St. Jude, state-of-art high-performance computing facilities, robust analytical pipelines, the latest laboratory technology, outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science.
ID
43564
Department
Computational Biology
Faculty Member
Paul Geeleher

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