Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

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St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS). Other benefits include: - Access to exceptional core facilities to help advance your research. - Opportunity to obtain a Master of Public Health in epidemiology or biostatistics with full tuition. - Opportunity to participate in St. Jude Global Pediatric Medicine conducting research in Central America, South America, Mexico, Eastern Mediterranean region, China, and Southeast Asia. St. Jude offers highly competitive stipends and benefits and fosters professional development.   St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. It is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.  St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and is an Equal Opportunity Employer. For more information, visit www.stjude.org.
ID
44025
Department
Academic Programs
Faculty Member
Kevin Krull
The Yang Lab in the Department of Pharmaceutical Sciences and the Yu Lab in the Department of Computational Biology are jointly recruiting a highly motivated postdoctoral research associate to work on systems biology projects related to pediatric leukemia. Our labs are interested in developing and implementing novel computational biology tools, including NetBID (Gocho et al., Nature Cancer 2021), by integrating multi-omics data at both bulk and single-cell levels, to dissect the signaling circuitry related to leukemia biology and drug response. The candidate will work along with pharmacologists, cancer biologists, and clinicians to analyze large-scale genomic datasets and to identify molecular drivers for a variety of leuekmia phenotypes, to develop novel therapy for children with this cancer. The successful applicant will work in a dynamic and productive environment with exposure to research from basic biology, preclinical drug evaluation, to clinical trial development.   As one of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the infrastructure in our labs with the goal of providing postdocs flexibility and freedom to develop their research programs.   St. Jude provides a highly interactive and supportive environment for researchers’ career development and has been named to Glassdoor’s Best Places to Work 2018. St. Jude is a top-ranked hospital (#1 for pediatric cancer specialty in the U.S. in 2017) and a world-class basic research institute with 260+ faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary in an affordable city, a professional development allowance ($1,875), and an array of benefits, including sign-on bonus, health, dental and vision coverage, and a retirement program.   Interested candidates, please complete the online application and email your CV and cover letter to jun.yang@stjude.org
ID
43961
Department
Pharmaceutical Sciences
Faculty Member
Jun Yang
The group of Assistant Professor Tommaso Cupido at St Jude Children's Research Hospital (Memphis, TN) is seeking a highly motivated postdoctoral researcher to develop and apply cutting edge chemical biology and structural approaches for studying gene expression regulation by protein machines, at the molecular level.   A major focus of the lab is to understand the mechanism and regulation of nucleic acid-interacting enzymes, whose aberrant function is implicated in cancer development and resistance to chemotherapy. Our efforts are highly multidisciplinary, centered on small molecule chemistry and integrating biochemistry, structural biology, genomics, as well as systems biology.   Applications should include a letter of motivation stating research interests and expertise, a CV, and two references' contact information.
ID
43929
Department
Chemical Biology & Therapeutic
Faculty Member
Tommaso Cupido
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital.    As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research.   For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.     Salary and benefits are competitive.  Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.        
ID
43885
Department
Biostatistics
Faculty Member
Motomi Mori
St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. We are looking for a candidate to fill any of a number of roles in our highly interdisciplinary, collaborative environment, ranging from single-molecule fluorescence imaging of cells and biomolecules to photophysically-guided development of organic fluorophores. This requires a creative, team-oriented individual with strong leadership skills who is comfortable pursuing highly impactful scientific advances across a range of biological systems and disciplines. Experience with quantitative single-molecule biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. The role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.   Publication links: - Quantifying secondary transport at single-molecule resolution. - Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. - Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. - A partially-open inward-facing intermediate conformation of LeuT is associated with Na<sup>+</sup> release and substrate transport. - Aminoglycoside interactions and impacts on the eukaryotic ribosome. - Dynamics of P-type ATPase transport revealed by single-molecule FRET. - Miscoding-induced stalling of substrate translocation on the bacterial ribosome. - Single-molecule analysis of ligand efficacy in β<sub>2</sub>AR-G-protein activation. - Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging. - Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. - Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation. - Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. - Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. - Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. - Transport domain unlocking sets the uptake rate of an aspartate transporter. - Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. - Ultra-stable organic fluorophores for single-molecule research. - Allosteric control of the ribosome by small-molecule antibiotics. - Cyanine fluorophore derivatives with enhanced photostability. - Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. - Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
ID
43865
Department
Structural Biology
Faculty Member
Roger Altman
The Mefford lab is seeking a postdoctoral fellow in translational neuroscience to study genomic and epigenomic causes of pediatric epilepsy and related disorders. Project opportunities include: integrated analysis of genome and transcriptome data to identify novel causes of pediatric epilepsy; investigating epigenetic causes of epilepsy; and functional studies of genetic epilepsies using patient-derived stem cell models. 
ID
43835
Department
Center for Pediatric Neurological Disease Research
Faculty Member
Heather Mefford
Postdoctoral Fellowships in Omics, Cancer and Alzheimer’s Disease Research   Two postdoctoral positions are available for motivated candidates at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. Our group has contributed to the discovery of ubiquitin code (Cell 2009) and numerous novel pathways in Alzheimer’s disease (Neuron 2020). The successful applicant will have an opportunity to use a range of approaches, including mass spectrometry, single-cell proteomics, CRISPR and organoids to explore the pathogenesis of cancer or neurodegenerative diseases. The overarching aim is to study complex molecular interactions by chemistry, genetics and systems biology, providing novel insights into disease development, therapeutic intervention, and biomarker discovery for precision medicine (https://www.stjude.org/peng). Our postdoctoral fellows have extensive interaction with other members for career development in cutting-edge technologies and biomedical research. More than 10 alumni become principal investigators. Our publications are available on Google Scholar (200+ publications, 24,000+ citations). St. Jude is a top ranked hospital (#1 for pediatric cancer specialty in U.S. in 2017) and a world-class basic research institute with about 300 faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary (median $56,000) in an affordable city, a professional development allowance ($1,875), and an array of benefits, including sign-on bonus ($3,000), health, dental and vision coverage, and a retirement program.   Candidates must have an excellent publication record. Please submit CV, three references, a brief statement regarding previous work and future goals to Dr. Junmin Peng (junmin.peng@stjude.org), Member (Full Professor) in Departments of Structural Biology and Developmental Neurobiology, Director of Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital.
ID
43838
Department
Structural Biology
Faculty Member
Junmin Peng
Please apply here, in addition to specific postings, if you would like your CV reviewed by multiple faculty. Also apply here if you have been requested to do so by a recruiter.
ID
APO21
Department
Academic Programs
The Geeleher Lab is seeking outstanding candidates for a postdoctoral fellowship focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs. Current research areas - Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics. The postdoc will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications. - Developing statistical methods for integrating single cell and bulk tissue expression data to understand the relationship between common inherited genetic variation, gene expression, and drug response Chemotherapeutic response is a complex trait influenced by numerous factors. Inherited genetic variants influencing gene expression (expression quantitative trait loci, or eQTLs) have been identified as major contributors. However, our recent work has shown that the degree of influence of eQTLs on gene expression in cancer is less well understood than previously thought. The postdoc will explore how inherited genetic variation influences cancer risk, disease progression and drug response, building on methods developed in the lab to deconvolute eQTL signals from bulk tissue expression data to specific cell types. This work will aim to improve our understanding of inherited genetic variation in cancer and yield computational approaches applicable to a broad variety of complex traits and diseases.   About the Geeleher Lab   The lab of Dr. Paul Geeleher is in the Department of Computational Biology at St. Jude Children’s Research Hospital. Dr. Geeleher is recognized for developing innovative computational approaches and has led drug repurposing efforts, spearheaded publications in Nature, Genome Research, Genome Biology, Journal of the National Cancer Institute (JNCI) and Bioinformatics in the last five years and is funded by the NIH. Postdoctoral fellows in the lab will benefit from access to the wealth of high-quality genomics data generated at St. Jude, state-of-art high-performance computing facilities, robust analytical pipelines, the latest laboratory technology, outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science.
ID
43564
Department
Computational Biology
Faculty Member
Paul Geeleher
Changes in the Structure and Organization of the Genome During Neurogenesis   During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization (https://pecan.stjude.cloud/retinalnucleome). One of the most significant discoveries to come from this comprehensive analysis was the identification of a series of core regulatory circuit super-enhancers (CRC-SEs) adjacent to genes having important roles in retinal development, including Vsx2, Crx, Six3, Otx2, Fgf15, and Ascl1. Each of those CRC-SEs have been deleted in mice using CRISPR-Cas9 and analysis is ongoing. We are also analyzing the evolutionary conservation of those CRC-SEs in human stem cell derived retinal organoids. The results of these studies will be important for filling a fundamental gap in our knowledge about the role of CRC-SEs in retinal development and will set the stage for characterization of CRC-SEs in other genes required for retinogenesis. We are seeking a highly motivated postdoctoral fellow to study the role of CRC-SEs in retinal development and diseases such as macular degeneration and diabetic retinopathy. Training in epigenetics, retinal biology and human stem cell research is preferred.   Michael A. Dyer, Ph.D. Investigator, HHMI Chair and Member, Developmental Neurobiology Department Co-leader Developmental Biology and Solid Tumor Program St. Jude Children’s Research Hospital   @MichaelADyerLab www.stjude.org/dyer  
ID
43435
Department
Developmental Neurobiology
Faculty Member
Michael Dyer
A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of invasive candidiasis by identifying the molecular mechanisms underpinning antifungal resistance in the emerging fungal pathogen Candida auris, and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of C. auris.
ID
43301
Department
Pharmaceutical Sciences
Faculty Member
Phillip Rogers
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.   A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system.  We are particularly interested in dissecting the signaling pathways involved in innate and adaptive immune responses and cell death (NLRs, inflammasomes).  Please see the following articles: Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5. Cell (2015) 162(1):45-58. Nature Immunology (2015) 16(5):467-75. Immunity (2015) 42(4):654-64. Nature (2014) 516(7530):246-9. Nature (2013) 498(7453):224-7.    The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
ID
43259
Department
Immunology
Faculty Member
Thirumala-Devi Kanneganti
A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system and vascular smooth muscle precursors interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) and unpublished data define the existence of this connection in in vertebrates and we are now working to better understand key details. St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources, and a robust community of talented, engaged, and collaborative investigators. We seek an intelligent, friendly, enthusiastic, committed, and capable individual to join our team.   We are particularly seeking an individual with experience in developmental hematopoiesis. In addition to a Ph.D., applicants should have a record of publication, and experience with molecular, biochemical, and cell biological techniques. This position will provide an opportunity for considerable independence and intellectual development, as well as examination of comparative developmental hematopoiesis.   The Clements lab is a friendly group with a keen interest in understanding blood ontogeny and its relationship to malignancy. We support work/life balance and believe that individual happiness is fundamental to scientific discovery and professional fulfillment. Memphis is a vibrant city in the mid-South, with a temperate climate, very active music scene, excellent restaurants, many family-friendly activities, and extremely affordable housing. St Jude Children's Research Hospital offers competitive salary, excellent benefits, and is an equal opportunity employer. Please send a cover letter describing research interests and accomplishments, CV, and the names and addresses of three references to wilson.clements@stjude.org.   https://www.stjude.org/clements https://twitter.com/Zfish_Blood_Lab https://www.linkedin.com/in/wilsonclements/
ID
43118
Department
Hematology
Faculty Member
Wilson Clements
A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.   Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics and computer science.    St. Jude provides a highly interactive and supportive environment for researchers’ career development.   St. Jude Children's Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, sexual orientation, gender identity, transgender status, age, religion, disability, veteran's status or disabled veteran's status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.   Interested candidates, please complete online application and submit CV to ComputationalBiologyRecruitment@stjude.org.
ID
43033
Department
Collaborative Research Program
Faculty Member
Jinghui Baker
We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN.  Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients.  His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes.  Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drives cancer formation.  We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.    Dr. Roberts’ research is highly regarded and he has been elected to the American Association of Clinical Research, the Society for Pediatric Research, the American Pediatric Society and American Association of Physicians.  He is a passionate mentor, and is fully committed to training the next generation of scientists. In addition to being the Director of the NCI designated St. Jude Comprehensive Cancer Center, Dr. Roberts leads a very successful well-funded team with postdoctoral scientists, graduate students, technologists, senior scientists, a dedicated bioinformatician. You will receive outstanding training in the development of scientific thinking and other skills such as grant writing, manuscript writing, and effective presentation, as well as have the freedom to develop your own ideas in a rigorous and supportive environment. Previous postdocs and graduate student trainees have successfully pursued careers as leaders in academia and industry. A list of previous trainees is available upon request.   The Division of Molecular Oncology and the top-notch core resources at St. Jude Children’s Research Hospital will allow you access to the world-class expertise and technology necessary to perform high level science. In addition, postdoctoral fellows at St. Jude receive a generous yearly Professional Development Allowance for travel to scientific meetings.
ID
42716
Department
Oncology
Faculty Member
Charles Roberts
  Postdoctoral Research Associate-Cell Biology of Neural Development St. Jude Children’s Research Hospital   St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research. Description Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective.    Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration, and polarization.   Contact To apply for this position, submit the online application, and send a C.V. and 3 letters of recommendation to: David J. Solecki, PhD, Department of Structural Biology, Mail Stop 311, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA, david.solecki@stjude.org.
ID
42727
Department
Developmental Neurobiology
Faculty Member
David Solecki
The postdoctoral fellow will have expertise in biochemistry, molecular biology as well as experience with animal models.  The projects will utilize biochemistry, cell culture, cell biology and animal models of disease.  The goal will be used to understand how and where these proteins affect pathways in disease progression. 
ID
39791
Department
Pharmaceutical Sciences
Faculty Member
John Schuetz
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.   Multiple postdoctoral positions are available in the laboratory of Dr. Thirumula-Devi Kanneganti, Department of Immunology at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system.  We are particularly interested in dissecting the signaling pathways involved in innate and adaptive immune responses and cell death (NLRs, inflammasomes).  Please see the following articles: Cell (2021) 184(1)_149-168.e17. Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5. Cell (2015) 162(1):45-58. Nature Immunology (2015) 16(5):467-75. Immunity (2015) 42(4):654-64. Nature (2014) 516(7530):246-9. Nature (2013) 498(7453):224-7.    The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.   Contact Information Thirumala-Devi Kanneganti, PhD Member Department of Immunology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN  38105-3678 E-mail: thirumala-devi.danneganti@stjude.org https://www.stjude.org/kanneganti
ID
39551
Department
Immunology
Faculty Member
Thirumala-Devi Kanneganti
Postdoctoral Research Associate in Immunology and Immunometabolism in Dr. Hongbo Chi’s Laboratory   Summary Immunology postdoctoral positions are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital (www.stjude.org/chi), to investigate discovery and cancer immunology, by focusing on cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in understanding the metabolic programs (e.g. glucose, lipid, and mitochondrial metabolism), signaling pathways (e.g. mTOR and Hippo kinases; metabolite- and nutrient-induced signaling), and systems-level regulatory networks (e.g. interactions between protein regulators and their targets) in basic T cell and dendritic cell biology and antitumor immunity. To this end, we apply interdisciplinary strategies by integrating immunological and genetic approaches with cutting-edge systems immunology tools, including single-cell transcriptomics, proteomics, metabolomics, network reconstruction, and in vivo CRISPR screening. Please see the following articles published over the past four years for additional information: Nature Epub ahead of print (2021); Cell Epub ahead of print (2021); Cell Metabolism 32:996 (2020); Nature Reviews Immunology 20:55 (2020); Nature 565:101 (2019); Nature 576:471 (2019); Immunity 51:1012 (2019); Nature 558:141 (2018); Immunity 49:899 (2018); Science Immunology aas9818 (2018); Nature 548:602 (2017); Immunity 46:488 (2017).   St. Jude Children’s Research Hospital, ranked a best children's hospital for pediatric cancer, offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salary and excellent benefits, to postdoctoral fellows.
ID
38521
Department
Immunology
Faculty Member
Hongbo Chi

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