Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

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One postdoctoral position is available immediately for motivated candidates at St. Jude Children’s Research Hospital, a premier center for biomedical research located in Memphis, Tennessee, USA. The successful applicant will have a unique opportunity to use a range of biochemical and genetic technologies, especially cutting-edge mass spectrometry-based proteomics and metabolomics, to explore the pathogenesis of cancer and neurodegenerative diseases in human iPSC-derived organoids, mouse models and clinical tissues. The overarching aim is to study complex molecular networks by structural, chemical, genetic and systems biology approaches, providing novel insights into disease development, therapeutic intervention, and biomarker discovery for precision medicine (https://www.stjude.org/peng).   Our postdoctoral fellows have extensive interaction with other members for career development in the fields of state-of-the-art technology development and biomedical research. Our publication record is available on Google Scholar (200+ publications and 28,000+ citations). The Center for Proteomics and Metabolomics is equipped with eight modern mass spectrometers and high performance computing clusters, and St. Jude has abundant resources in large-scale gene editing, structural biology (including CryoEM), super-resolution imaging and high-throughput chemical screening. More than 10 group alumni become principal investigators. St. Jude is a top ranked hospital (No. 2 pediatric cancer hospital on U.S. News & World Report in 2019) and a world-class basic research institute with about 300 faculty members. St. Jude postdoctoral fellows are provided with a competitive salary in an affordable city, a professional development allowance, and an array of benefits, including sign-on bonus, health, dental and vision coverage, and a retirement program.
ID
48843
Department
Structural Biology
Faculty Member
Junmin Peng
Postdoctoral Research Associate in Neuroscience / Neurobiology   The Bikoff lab (https://www.stjude.org/research/labs/bikoff-lab.html) is seeking a highly motivated postdoctoral researcher interested in studying neural circuitry in mice.   The fundamental goal of our research is to understand how neural circuits control movement. We approach this from multiple perspectives, using cutting-edge technologies to analyze the molecular diversity of spinal interneurons, explore how descending systems in the brain convey information to the spinal motor system, and define the functional roles of spinal interneurons in generating behavior.   These projects are highly multidisciplinary, taking advantage of a wide range of techniques including viral tracing, optogenetics and electrophysiology, whole-brain imaging, single-cell transcriptomics, and quantitative approaches to behavior. We welcome applicants from diverse backgrounds that would thrive in a highly collaborative, fun, and supportive environment that provides the freedom to independently develop a research project.   The Bikoff lab is strongly committed to providing individual mentoring and training, as well as ongoing support at all stages of career development.   Applications: Individuals with evidence of scientific accomplishment are encouraged to apply by sending their CV, a brief description of research interests, and contact information for three references to: jay.bikoff@stjude.org.
ID
48844
Department
Developmental Neurobiology
Faculty Member
Jay Bikoff
A fully funded postdoctoral position is immediately available Mark Hatley’s laboratory in the Molecular Oncology Division of the Department of Oncology at St. Jude Children’s Hospital. The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our recent findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018). We now seek to elucidate the mechanism of this cell reprogramming event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as induced pluripotent stem cells as model systems to interrogate the underlying pathobiology of pediatric rhabdomyosarcoma.   The Hatley lab is a very collaborative, interactive environment focused on scientific and career development of trainees. The lab supports a healthy work/life balance and diversity with a focus on career development. Four former postdocs are now tenure track Assistant Professors at academic institutions. Dr. Hatley was the 2019 mentor of the year at St. Jude. Successful applicants should have strong organizational and communication skills with drive and dedication to participate as a member of our team. https://www.stjude.org/research/labs/hatley-lab.html @HatleyLab  
ID
48868
Department
Oncology
Faculty Member
Mark Hatley
A postdoctoral position isavailable in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood system; transcriptional dysregulation of bone marrow niche in hematological disorders and bone marrow niche-induced changes of chromatin landscape in hematopoietic progenitors. In this position, you will have a chance to lead your projects and mature into fully independent researcher. Successful candidate will gain an experience in genome wide technology, CRISPR-Cas editing, mouse models and stem cell biology. St. Jude offers a cutting-edge scientific and training environment, combining both clinical and basic research. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
48774
Department
Hematology
Faculty Member
Marta Derecka
Postdoctoral Research Associate St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.   A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system.  We are particularly interested in dissecting the signaling pathways involved in innate immune responses and cell death (NLRs, inflammasomes, and inflammatory cell death, PANoptosis).  Please see the following articles: Science Immunology (2022) [Epub ahead of print] Nature (2021) 597(7876):415-9.Cell (2021) 184(1)_149-168.e17. Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5.   The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
ID
48787
Department
Immunology
Faculty Member
Thirumala-Devi Kanneganti
Postdoc project in dynamic structural biology: Exploiting Water Network Perturbations in Protein Binding Sites We are recruiting a postdoc for a structural biology project that investigates the role of water networks at protein ligand interfaces with a view towards ligand discovery. The position is available immediately and NIH funded for 4 years. We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein-ligand binding and leverage this information for ligand discovery. As this project integrates experimental and computational data it will require both a solid background in structural biology and significant computational skills for custom data analysis and automation. Despite the focus on computational structural biology, we will consider exceptional candidates with a suitable experimental background and a strong interest in protein dynamics, ligands and water. The project is housed in the Department of Chemical Biology and Therapeutics, and Structural Biology at St. Jude Children’s Research Hospital. It builds on strong investments into a world-class infrastructure in structural and chemical biology. You will be embedded into a dynamic lab that has strong expertise in modulating protein conformational ensembles with ligands and temperature (see references below). This is an exciting time to join us and build a career while living in an affordable city.   Please direct your questions and application package including a cover letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (marcus.fischer@stjude.org). Relevant papers include: • Bradford et al. (2021). Temperature artifacts in protein structures bias ligand-binding predictions. Chemical Science. DOI: 10.1039/D1SC02751D • Fischer (2021). Macromolecular room temperature crystallography. Q Rev Biophys 54. E1 • Darby et al. (2019). Water Networks Can Determine the Affinity of Ligand Binding to Proteins. JACS 141, 15818-26. • Balius et al. (2017). Testing inhomogeneous solvation theory in structure-based ligand discovery. PNAS E6839-46. • Fischer et al. (2015). One crystal, two temperatures: cryocooling penalties alter ligand binding to transient protein sites. Chembiochem 1560-64. • Fischer et al. (2014). Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry 6, 575-83. More info at: https://www.stjude.org/fischer
ID
48711
Department
Chemical Biology & Therapeutics
Faculty Member
Marcus Fischer
A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of invasive aspergillosis by identifying the molecular mechanisms underpinning antifungal resistance in the fungal pathogen Aspergillus fumigatus, and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of A. fumigatus.
ID
48638
Department
Pharmaceutical Sciences
Faculty Member
Phillip Rogers
The St. Jude Liaison Office enhances the partnership between St. Jude Children's Research Hospital and ALSAC by serving as St. Jude's point of contact for ALSAC's marketing needs while balancing the patient care and operational imperatives of St. Jude.    St. Jude Liaison Office Project Leaders (Content) assist with management of ALSAC content needs on behalf of St. Jude. In a fast-paced work environment, the Project Leaders (Content) follow a content strategy, review complex scientific and/or clinical content, fact-check and substantiate. The Project Leaders (Content) participate in fundraising-focused interviews with St. Jude faculty and staff. The Project Leaders (Content) provide clarity, support efficient operations and support ALSAC fundraising efforts by taking responsibility for current and relevant information required for scripts and marketing materials. Project Leaders (Content) also assist with coordination of events, tours, and visitors on campus, coordinate St. Jude faculty and staff for engagement opportunities and provide subject matter expertise. Excellent follow-up and timeliness, accountability for work solutions, as well as excelling under pressure with urgent requests is required.   The ideal Project Leader (Content) candidate has a scientific or clinical background, experience in editing or publishing, and excellent written and oral communication skills. The ideal candidate has strong grammar skills and attention to detail, is able to meet competing deadlines, works well under pressure, and collaborates seamlessly with others.   This position reports to the Director of the St. Jude Liaison Office.  A credit check may be required for this position.   
ID
48652
Department
Liaison Office
Faculty Member
Christine Walters
Postdoctoral positions are available in the McKinney-Freeman laboratory of the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study the fundamental biology of hematopoietic stem cells (HSCs).   HSCs represent the most therapeutically exploited adult stem cell compartment, used routinely to treat leukemia and hematologic disease via HSC transplantation. Our major goals are to 1) illuminate the intrinsic and extrinsic factors that control the ability of HSC to home to, engraft, and repopulate the hematopoietic compartment after transplantation, 2) better understand the development of the HSC pool and bone marrow niche during early life and 3) uncover how chronic hematologic disease corrupts HSCs, with a particular focus on Sickle Cell Disease.   We hope to leverage this knowledge to design therapies targeted at improving HSC transplantation for hematologic disease and gene therapy, as well as illuminate mechanisms of hematopoietic failure during chronic hematologic disease.   Current ongoing projects for which positions are available include exploring novel signals that regulate the function of HSCs in the early bone marrow niche via interrogation of a novel single cell transcriptomic atlas and interrogating the function of HSCs and their bone marrow niche during Sickle Cell Disease in children and adults. We employ both genetic mammalian model systems and primary patient samples to pursue these aims.    St. Jude Children’s Research Hospital, located in Memphis, Tennessee, USA, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.   If interested, please contact Shannon McKinney-Freeman at Shannon.mckinney-freeman@stjude.org See also: http://www.stjuderesearch.org/site/lab/mckinney-freeman    
ID
48597
Department
Hematology
Faculty Member
Shannon McKinney-Freeman
Postdoctoral Research Associate in Radiochemistry and Molecular Imaging Molecular Imaging Hub, St. Jude Children´s Research Hospital, Memphis (TN), USA Contact: kielneumann@gmail.com   The Neumann lab is seeking candidates for a full-time postdoctoral research associate. The successful candidate will be responsible for developing novel imaging agents for use in Positron Emission Tomography (PET). Current projects in the Neumann lab focus on cancer, infectious disease, and oxidative stress imaging in various preclinical models. The ideal candidate should have a strong background in synthetic chemistry and radiochemistry, relevant cell culture training, some experience in small animal work, and an interest in in vivo imaging and translational science. The successful applicant will work as part of a collaborative team and will have access to a wide range of equipment, including a DOI PET/CT scanner, PET/MRI, focused ultrasound (FUS), on-site cyclotron, 18F and 11C synthesis modules, hot cells, liquid scintillation equipment, automated HPLCs and more. A dedicated cell and molecular biology laboratory, fully equipped for biological assays, will also be available. The candidate will also be cross-trained in Focused Ultrasound techniques to improve delivery of novel radiopharmaceuticals to the Central Nervous System.   Individuals interested in applying should submit: - Current CV - Research Statement summarizing how your planned research aligns with career goals (1 page or less) - Three letters of recommendation
ID
48612
Department
Diagnostic Imaging
Faculty Member
Kiel Neumann
We are excited to announce a postdoctoral fellowship in the laboratory of Dr. Lillian Guenther in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN.  Dr. Guenther’s research specifically focuses on identification of novel therapeutic targets in osteosarcoma. Dr. Guenther’s research has utilized genome-scale CRISPR screening and other complementary large-scale chemical and genomic screening modalities in multiple types of pre-clinical models to uncover novel dependencies, or critical osteosarcoma-specific survival genes. Research in the Guenther laboratory is designed to discover how such critical osteosarcoma dependency genes enable cell growth, with an eye towards clinical translation. We are specifically interested in enrichment for DNA damage repair and replication stress-related targets in this disease, and how this biology may be optimally exploited to better treat patients.   Dr. Guenther is a passionate physician-scientist and has been a mentor to trainees of all levels. She is committed to training post-doctoral fellows in the development of scientific thinking and skills such as grant writing, manuscript writing, and effective presentation. Dr. Guenther will encourage the postdoctoral fellow to develop their own scientific ideas and hypotheses in a rigorous and supportive environment. Candidates will be expected to write manuscripts, contribute to grant applications, and apply for fellowship grants as eligible, and have exceptional writing and presentation skills. Dr. Guenther is dedicated to fostering an inclusive, diverse workspace that fosters equity while advancing pediatric cancer research.   The Division of Molecular Oncology and the top-notch core resources at St. Jude Children’s Research Hospital will allow the candidate access to the world-class expertise and technology necessary to perform high level science. The St. Jude Post-Doctoral Association provides extensive support to trainees in the institution including career advancement, scientific writing and speaking seminars, as well as community-building events. In addition, postdoctoral fellows at St. Jude receive a generous yearly Professional Development Allowance for travel to scientific meetings.
ID
48520
Department
Oncology
Faculty Member
Stacy Throm
Open Call for Post-doctoral Researcher in Functional Imaging Multimodal Functional Brain Imaging Hub, St. Jude Children´s Research Hospital, Memphis (TN), USA. 3/25/2022 Contact: ranganatha.sitaram@stjude.org   The Employer: St. Jude Children’s Research Hospital has spent more than a half century conducting research into catastrophic diseases in children, including cancer, hematological disorders and various infections (e.g. pandemic viruses and HIV). St. Jude Children’s Research Hospital is the only National Cancer Institute designated Cancer Center that is dedicated solely to the research and treatment of pediatric malignancies. The mission of the Comprehensive Cancer Center at St. Jude Children's Research Hospital is to advance cures and means of prevention for pediatric cancer, the leading cause of disease-related death in children aged 1 to 14 years. The St. Jude Comprehensive Cancer Center supports several multidisciplinary research programs that are organized with the specific intent of translating basic science discoveries into curative therapies for children with cancer, while minimizing long-term side effects.   Multimodal Functional Brain Imaging in Pediatric Cancer: St. Jude is highly motivated to develop a novel research program to acquire cognitive and psychosocial data pre- and post-cancer therapy, for characterizing and predicting the effect of cancer and cancer-therapy on sensory, perceptual, cognitive and emotional aspects of brain function and behavior, and for developing interventions with brain modulation and stimulation techniques to reverse the adverse cognitive effect of pediatric cancer. This new program would heavily rely on the application of multimodal functional brain imaging which requires highly sophisticated imaging techniques, such as functional magnetic resonance imaging (fMRI), functional Near Infrared Spectroscopy (fNIRS), electro/magnetoencephalography (EEG/MEG) and brain stimulation combined with novel experimental paradigms. In addition, novel computational neuroscience and artificial intelligence methods including functional and effective connectivity, causality modeling, real-time imaging, brain-computer interfaces and neurofeedback would be key tools for scientific investigation and translational intervention in this new research program.   Candidate eligibility and requirements:We are looking for talented and motivated individuals to fill a post-doctoral researcher position to conduct research in functional MRI, real-time fMRI and related approaches to conduct cognitive neuroscience research in pediatric oncology. All candidates are expected to have completed PhD or equivalent doctoral degree in neuroscience, biomedical engineering, biomedical sciences, electronic/electrical engineering, physics, mathematics, computer science, psychology, or related areas. Other strong requirements include demonstrated experience and ability to conduct experimental work on humans or animal models, skills in analytical and computational techniques, and excellent written and spoken communication skills. Candidates with demonstration of peer-reviewed journal publications, patents and conference presentations are preferred.    
ID
48330
Department
Diagnostic Imaging
Faculty Member
Ranganatha Sitaram
Dr. Kundu's lab currently has an opening for a postdoctoral research fellow.  The project will be to investigate the role of ulk1/2 in hematopoietic stem cells. 
ID
48218
Department
Cell & Molecular Biology
Faculty Member
Mondira Kundu
Career Opportunity Division of Cancer Predisposition St Jude Children’s Research Hospital   The Nichols Lab at St. Jude Children's Research Hospital is seeking a highly motivated Postdoctoral Fellow with interests and research experience in hematopoiesis, stem cell biology or leukemia modeling to carry out projects in cancer predisposition.   We are interested in identifying novel genes and genetic variants that contribute to development of cancer and primary immunodeficiency. In 2015, we and others identified germline variants in ETV6, the gene encoding the essential hematopoietic transcription factor ETV6, in families affected by autosomal dominant thrombocytopenia and predisposition to B-acute lymphoblastic leukemia (B-ALL). We are now using human and mouse models to decipher how these germline ETV6 variants impact hematopoiesis and promote leukemogenesis.   Towards this end, we have generated a knock-in mouse model harboring a heterozygous germline Etv6 variant that mimics a human variant observed in multiple kindreds. We are characterizing the hematopoietic phenotypes of these animals and examining the transcriptional mechanisms by which ETV6 regulates these processes. To model these cell compartments and perform assays in vitro, we also employ a number of cell lines including murine-derived HSPCs and pro-B cells, as well as human iPSCs. To study the role of ETV6 in malignancy, we have crossed the Etv6 variant mice with other mouse strains carrying known cooperating events identified in leukemia samples. Ultimately, our goal is to better understand how germline and somatic genetic events perturb key cellular and molecular pathways that then lead to leukemia.   The Postdoctoral Fellow should have experience working with mice, such as breeding, genotyping, harvesting organs, completing flow cytometry. A background in hematopoiesis or leukemia modeling is desired.   The Nichols lab provides a highly collaborative and interactive environment where the postdoctoral fellow will have ample opportunities to participate in research initiatives centered around germline and tumor genomics. The postdoctoral fellow will access to many shared resources within the Department of Oncology and St. Jude Cancer Center, which will facilitate research initiatives and ensure their success.   This is a remarkable opportunity to be part of a positive workplace where all employees, regardless of their role, share the same commitment to make a difference in the lives of children with cancer and other catastrophic illnesses. St. Jude is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” and is No. 9 on the 2018 Glassdoor “Best Place to Work” list for companies with 1,000 or more employees.   This position is based in Memphis, TN with relocation assistance available. The facilities and salaries are competitive, and a generous benefit package is included. Memphis is a family-friendly metropolitan area that is recognized for its world-class music, food and hospitality. Mild winters and beautiful green spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. If interested, please contact Kim Nichols, MD (kim.nichols@stjude.org) or 901-484-7789 (cell).
ID
44658
Department
Oncology
Faculty Member
Kim Nichols
A postdoctoral research associate position is immediately available in the laboratory of Dr. Xiang Chen in the department of Computational Biology to develop and apply computational approaches to understand interactions between genetic alterations and epigenetic deregulations and to discover potential biomarkers for predicting drug responses in pediatric cancers. We are looking for a talented and highly motivated candidate who have a strong background/interest in molecular biology and computational biology. The candidate will work closely with Dr. Chen and staff scientists in his lab with the end goal of contributing to the discovery of novel (epi-)drivers and treatment protocols for pediatric cancers using high dimensional genomic, epigenomic, transcriptomic and proteomic data generated from bulk or single-cell tumor specimens.   The lab will provide working experience for a postdoctoral research associate who is interested in leading or participating in all aspects of cancer omics studies via multi-disciplinary teamwork with mentoring from Dr. Chen and other scientists. The selected candidate will have opportunities to interact with leaders in the fields of pediatric cancer and translational research within and outside the institution. Innovative research leading to high-impact scientific publication is highly encouraged and will be supported by the department’s research infrastructure. For those with ambitious career goals, inter-disciplinary training will be provided to broaden or strengthen computational or biological expertise.   St. Jude provides a highly interactive and supportive environment for researchers’ career development.
Department
Computational Biology
Faculty Member
Xiang Chen
We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN.  Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients.  His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes.  Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation.  We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.    Dr. Roberts’ research is highly regarded and he has been elected to the American Association of Clinical Research, the Society for Pediatric Research, the American Pediatric Society and American Association of Physicians.  He is a passionate mentor and is fully committed to training the next generation of scientists. In addition to being the Director of the NCI designated St. Jude Comprehensive Cancer Center, Dr. Roberts leads a very successful well-funded team with postdoctoral scientists, graduate students, technologists, senior scientists, and a dedicated bioinformatician. You will receive outstanding training in the development of scientific thinking and other skills such as grant writing, manuscript writing, and effective presentation, as well as have the freedom to develop your own ideas in a rigorous and supportive environment. Previous postdocs and graduate student trainees have successfully pursued careers as leaders in academia and industry. A list of previous trainees is available upon request.   The Division of Molecular Oncology and the top-notch core resources at St. Jude Children’s Research Hospital will allow you access to the world-class expertise and technology necessary to perform high level science. In addition, postdoctoral fellows at St. Jude receive a generous yearly Professional Development Allowance for travel to scientific meetings.
ID
48116
Department
Oncology
Faculty Member
Charles Roberts
We are excited to announce a postdoctoral fellowship available in the laboratory of Dr. Charles Roberts in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN.  Dr. Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients.  His research specifically focuses on SWI/SNF (BAF) chromatin remodeling complexes.  Perturbation of these complexes has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanisms by which SWI/SNF complexes regulate chromatin and transcriptional control and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drive cancer formation.  We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. Based on work pioneered in his lab, in January of 2020 the FDA granted approval of the EZH2 inhibitor Tazemetostat for cancers that contain SMARCB1/INI1 mutations.    Dr. Roberts’ research is highly regarded and he has been elected to the American Association of Clinical Research, the Society for Pediatric Research, the American Pediatric Society and American Association of Physicians.  He is a passionate mentor and is fully committed to training the next generation of scientists. In addition to being the Director of the NCI designated St. Jude Comprehensive Cancer Center, Dr. Roberts leads a very successful well-funded team with postdoctoral scientists, graduate students, technologists, senior scientists, and a dedicated bioinformatician. You will receive outstanding training in the development of scientific thinking and other skills such as grant writing, manuscript writing, and effective presentation, as well as have the freedom to develop your own ideas in a rigorous and supportive environment. Previous postdocs and graduate student trainees have successfully pursued careers as leaders in academia and industry. A list of previous trainees is available upon request.   The Division of Molecular Oncology and the top-notch core resources at St. Jude Children’s Research Hospital will allow you access to the world-class expertise and technology necessary to perform high level science. In addition, postdoctoral fellows at St. Jude receive a generous yearly Professional Development Allowance for travel to scientific meetings.
ID
48117
Department
Collaborative Research Program
Faculty Member
Charles Roberts
The successful applicant will participate in a dynamic, international collaborative research project to determine virologic and host factors associated with influenza virus host switching. It is envisaged that the individual will spend time in the St Jude Departments of Infectious Diseases and Immunology and will be exposed to cutting edge methodologies in each discipline. While not required, expertise in basic microbial techniques and cell culture would be of benefit. Utilization of animal models will be required.
ID
48124
Department
Infectious Diseases
Faculty Member
Richard Webby
St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. We are looking for a candidate to fill any of a number of roles in our highly interdisciplinary, collaborative environment, ranging from single-molecule fluorescence imaging of cells and biomolecules to photophysically-guided development of organic fluorophores. This requires a creative, team-oriented individual with strong leadership skills who is comfortable pursuing highly impactful scientific advances across a range of biological systems and disciplines. Experience with quantitative single-molecule biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. The role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.   Publication links: - Quantifying secondary transport at single-molecule resolution. - Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. - Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. - A partially-open inward-facing intermediate conformation of LeuT is associated with Na<sup>+</sup> release and substrate transport. - Aminoglycoside interactions and impacts on the eukaryotic ribosome. - Dynamics of P-type ATPase transport revealed by single-molecule FRET. - Miscoding-induced stalling of substrate translocation on the bacterial ribosome. - Single-molecule analysis of ligand efficacy in β<sub>2</sub>AR-G-protein activation. - Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging. - Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. - Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation. - Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. - Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. - Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. - Transport domain unlocking sets the uptake rate of an aspartate transporter. - Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. - Ultra-stable organic fluorophores for single-molecule research. - Allosteric control of the ribosome by small-molecule antibiotics. - Cyanine fluorophore derivatives with enhanced photostability. - Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. - Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
ID
48042
Department
Structural Biology
Faculty Member
Scott Blanchard
Postdoctoral Fellowship Program Department of Biostatistics   St. Jude is seeking an outstanding candidate for postdoctoral fellow in multi-omics research. As a fellow you will join Dr. Qian Li’s lab in the Department of Biostatistics, providing computational or statistical support and developing analytical methods at the cutting edge of omics studies. You will benefit from access to unique datasets and expertise; top-ranked scientific environment; and superb benefits, mentoring, and professional development.   One position is available with an appointment of two years. Dr. Qian Li’s methodological research focuses on (temporal) omics data, such as transcriptomics, metagenomics, and metabolomics. This postdoctoral fellow will develop innovative methods and tools for large-scale omics data analysis, including the integration of multi-omics data, in pediatric catastrophic disease. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS), and the largest pediatric cancer genome database, St. Jude Cloud.   St. Jude offers highly competitive stipends and benefits and fosters professional development.   To learn more, please contact and send cover letter, CV, and three recommendation letters to Qian Li, PhD Assistant Member Department of Biostatistics St. Jude Children’s Research Hospital qian.li@stjude.org  
ID
47981
Department
Biostatistics
Faculty Member
Qian Li

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