Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

Use this form to perform another job search or to set up job alerts

The system cannot access your location for 1 of 2 reasons:
  1. Permission to access your location has been denied. Please reload the page and allow the browser to access your location information.
  2. Your location information has yet to be received. Please wait a moment then hit [Search] again.
Click column header to sort

Search Results Page 1 of 2

The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer.  The project will include assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.
ID
44212
Department
Immunology
Faculty Member
Benjamin Youngblood
Postdoctoral Associate Position in Structural Biology    The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the role of liquid-liquid phase separation in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. Data will be interpreted through a polymer physics lense and supplemented through simulations via a collaboration with Dr. Rohit Papu’s laboratory at Washington University in St. Louis.   The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.       Contact Information  Tanja Mittag, PhD  Department of Structural Biology  St. Jude Children’s Research Hospital  262 Danny Thomas Place  Memphis, TN  38105-3678  E-mail: tanja.mittag@stjude.org  https://www.stjude.org/mittag 
ID
44201
Department
Structural Biology
Faculty Member
Tanja Mittag
St. Jude Children’s Research Hospital are seeking highly motivated candidates to join the laboratory of Dr. Chia-Hsueh Lee in the Department of Structural Biology as a postdoctoral fellow to lead exciting research initiatives. The lab use cryo-EM and a range of biochemical/biophysical methods to study the function of membrane proteins (e.g. Wang et al., NSMB 2021; Lee and MacKinnon, Cell, 2019; Lee and MacKinnon, Science, 2018).   The lab has frequent access to the state-of-the-art cryoEM facility at St. Jude, which houses a 300kV Titan Krios, a 200kV Arctica, and a 120kV Talos L120C microscope. We are looking for an individual who have a passion for learning and navigating new research fields and is comfortable pursing highly impactful scientific advances.
ID
44202
Department
Structural Biology
Faculty Member
Chia-Hsueh Lee
St. Jude Children’s Research Hospital are seeking highly motivated candidates to join the laboratory of Dr. Chia-Hsueh Lee in the Department of Structural Biology as a postdoctoral fellow to lead exciting research initiatives. The lab use cryo-EM and a range of biochemical/biophysical methods to study the function of membrane proteins (e.g. Wang et al., NSMB 2021; Lee and MacKinnon, Cell, 2019; Lee and MacKinnon, Science, 2018).   The lab has frequent access to the state-of-the-art cryoEM facility at St. Jude, which houses a 300kV Titan Krios, a 200kV Arctica, and a 120kV Talos L120C microscope. We are looking for an individual who have a passion for learning and navigating new research fields and is comfortable pursing highly impactful scientific advances.
ID
44203
Department
Structural Biology
Faculty Member
Chia-Hsueh Lee
St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine. The institution has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients.   The Department of Structural Biology is seeking a photochemist to help lead theoretical and design aspects of our ongoing fluorophore synthesis and photophysics research in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also help lead chemical biology initiatives aimed at advancing mechanistic studies of clinically important biological systems at the single-molecule scale. The lab’s highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.   Training opportunity and responsibilities - Photophysical characterizations (steady-state and time-resolved) of cyanine- and rhodamine-class organic fluorophores at both ensemble and single-molecule levels. - Electrochemical characterizations of cyanine- and rhodamine-class organic fluorophores. - Collaboratively designed quantum chemical calculations. - Mechanistic understanding of photophysics of cyanine- and rhodamine-class organic fluorophores. - Generate hypotheses-driven design strategies in collaboration with our chemistry team. - Presentation of experimental data and research progress in collaborative, cross-disciplinary settings. - Effectively communicate and help advance multidisciplinary team-based research projects. - Follow safety guidelines and contribute to the maintenance of spectroscopy equipment.
ID
44170
Department
Structural Biology
Faculty Member
Roger Altman
The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how acquired mutations in hematopoietic stem cells lead to the development of clonal hematopoiesis and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.   You will have the opportunity to develop and lead projects using several cutting-edge model systems including:   - Isogenic immortalized cell lines generated using CRISPR-Cas gene editing - Novel xenograft and transgenic in vivo systems - Primary patient samples   In this position, you will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study development.   St. Jude Children’s Research Hospital is a top-ranked Pediatric Cancer Hospital and a world-renowned basic science research institute with over 200 faculty members. St. Jude offers a highly collaborative research and training environment that includes state-of-the-art facilities and resources. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
44136
Department
Oncology
Faculty Member
Esther Obeng
Dr. Martine F. Roussel, Department of Tumor Cell Biology, has two exciting new postdoc positions available in her laboratory.   Project 1. MYCN is overexpressed in a variety of childhood cancers, and aberrant MYCN expression is universally associated with a highly aggressive clinical phenotype, metastatic dissemination and low survival rates. The selected postdoc will play a major role in an integrated and multidisciplinary effort to discover and develop PROTACs that will directly degrade the MYCN protein in pediatric solid tumors.   Project 2. Develop novel targeted protein degradation approaches to selectively degrade key oncogenic transcription factors in high risk childhood leukemia and medulloblastoma, two of the leading causes of childhood cancer death. Phenotypic and targeted screening approaches, along with robust computational and structural biology analyses, will be employed to identify and develop molecular glues that will selectively degrade multiple transcription factors. If successful, new therapeutic options for subtypes of pediatric cancers may be identified, and this could lead to further development of therapies to treat many hitherto undruggable cancers.   Project 3. Understand the role of histone methyltransferases in MYC-driven Group3 medulloblastoma, the most aggressive form of this pediatric cerebellar disease.  High throughput screens of epigenetic regulators using CRISPR-Cas9 gene editing and shRNA identified several chromatin regulators including two histone methyltransferases that regulate MYC expression and antagonize each other.  Biomedical and molecular analysis will unravel how these proteins drive medulloblastoma development and progression.  Inhibitors developed against these epigenetic regulators might be potential therapeutic targets that will be tested in pre-clinical trials using mouse models and patient-derived xenografts.   Project 4.  To target the p53 pathway in atypical thyroid/rhabdoid tumors (ATRTs).  ATRTs are aggressive pediatric brain tumors that occur in very young children for whom novel therapies are warranted.  We propose to conduct pre-clinical trials inpatient-derivedorthotopicxenograft(PDOX)modelsofATRTto study the effect of compounds that target the p53 pathway in combination with radiation.   If interested, please contact Dr. Roussel by email at martine.roussel@stjude.org.
ID
44109
Department
Tumor Cell Biology
Faculty Member
Martine Roussel
A Postdoctoral research position is available in the Department of Immunology at St Jude Children’s Research Hospital.  The research fellow will broadly study the role of epigenetic programming during development of functional and non-functional virus and tumor-specific CD8 T cells.  Specific emphasis will be focused on epigenetic programming in antigen-specific CD8 T cells from murine and human model systems.
ID
44068
Department
Immunology
Faculty Member
Benjamin Youngblood
A fully funded postdoctoral position is immediately available in the Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a highly motivated candidate to investigate the genetic factors underpinning key human blood cell traits, particularly the functional impacts of non-coding regulatory elements during normal blood development and disorders.   https://www.stjude.org/directory/c/yong-cheng.html
ID
44042
Department
Hematology
Faculty Member
Yong Cheng
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital.  As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. A position is available in statistical research in longitudinal gut microbiome, whole blood RNA-Seq gene expression, and mass spectrometry metabolomics. Appointment is for two years.    For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.   Salary and benefits are competitive.  Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org. 
ID
43999
Department
Biostatistics
Faculty Member
Motomi Mori
St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS). Other benefits include: - Access to exceptional core facilities to help advance your research. - Opportunity to obtain a Master of Public Health in epidemiology or biostatistics with full tuition. - Opportunity to participate in St. Jude Global Pediatric Medicine conducting research in Central America, South America, Mexico, Eastern Mediterranean region, China, and Southeast Asia. St. Jude offers highly competitive stipends and benefits and fosters professional development.   St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. It is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.  St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and is an Equal Opportunity Employer. For more information, visit www.stjude.org.
ID
44025
Department
Academic Programs
Faculty Member
Kevin Krull
The Yang Lab in the Department of Pharmaceutical Sciences and the Yu Lab in the Department of Computational Biology are jointly recruiting a highly motivated postdoctoral research associate to work on systems biology projects related to pediatric leukemia. Our labs are interested in developing and implementing novel computational biology tools, including NetBID (Gocho et al., Nature Cancer 2021), by integrating multi-omics data at both bulk and single-cell levels, to dissect the signaling circuitry related to leukemia biology and drug response. The candidate will work along with pharmacologists, cancer biologists, and clinicians to analyze large-scale genomic datasets and to identify molecular drivers for a variety of leuekmia phenotypes, to develop novel therapy for children with this cancer. The successful applicant will work in a dynamic and productive environment with exposure to research from basic biology, preclinical drug evaluation, to clinical trial development.   As one of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the infrastructure in our labs with the goal of providing postdocs flexibility and freedom to develop their research programs.   St. Jude provides a highly interactive and supportive environment for researchers’ career development and has been named to Glassdoor’s Best Places to Work 2018. St. Jude is a top-ranked hospital (#1 for pediatric cancer specialty in the U.S. in 2017) and a world-class basic research institute with 260+ faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary in an affordable city, a professional development allowance ($1,875), and an array of benefits, including sign-on bonus, health, dental and vision coverage, and a retirement program.   Interested candidates, please complete the online application and email your CV and cover letter to jun.yang@stjude.org
ID
43961
Department
Pharmaceutical Sciences
Faculty Member
Jun Yang
The group of Assistant Professor Tommaso Cupido at St Jude Children's Research Hospital (Memphis, TN) is seeking a highly motivated postdoctoral researcher to develop and apply cutting edge chemical biology and structural approaches for studying gene expression regulation by protein machines, at the molecular level.   A major focus of the lab is to understand the mechanism and regulation of nucleic acid-interacting enzymes, whose aberrant function is implicated in cancer development and resistance to chemotherapy. Our efforts are highly multidisciplinary, centered on small molecule chemistry and integrating biochemistry, structural biology, genomics, as well as systems biology.   Applications should include a letter of motivation stating research interests and expertise, a CV, and two references' contact information.
ID
43929
Department
Chemical Biology & Therapeutic
Faculty Member
Tommaso Cupido
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital.    As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research.   For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.     Salary and benefits are competitive.  Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org.        
ID
43885
Department
Biostatistics
Faculty Member
Motomi Mori
Postdoctoral Fellowships in Omics, Cancer and Alzheimer’s Disease Research     Two postdoctoral positions are available for motivated candidates at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. Our group has contributed to the discovery of ubiquitin code (Cell 2009) and numerous novel pathways in Alzheimer’s disease (Neuron 2020). The successful applicant will have an opportunity to use a range of cutting-edge technologies, including mass spectrometry, single-cell omics and CRISPR, to explore the pathogenesis of cancer or neurodegenerative diseases in human organoids, mouse models and clinical tissues. The overarching aim is to study complex molecular interactions by chemical, genetic and systems biology approaches, providing novel insights into disease development, therapeutic intervention, and biomarker discovery for precision medicine (https://www.stjude.org/peng). Our postdoctoral fellows have extensive interaction with other members for career development in technologies and biomedical research. More than 10 alumni become principal investigators. Our publications are available on Google Scholar (200+ publications, 25,000+ citations). St. Jude is a top ranked hospital (#1 for pediatric cancer specialty in U.S. in 2017) and a world-class basic research institute with about 300 faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary (median $56,000) in an affordable city, a professional development allowance ($1,875), and an array of benefits, including sign-on bonus ($3,000), health, dental and vision coverage, and a retirement program.
ID
43837
Department
Structural Biology
Faculty Member
Junmin Peng
The Rosch Laboratory is seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship focused on pneumococcal genetics and host-pathogen interactions.
ID
43860
Department
Infectious Diseases
Faculty Member
Jason Rosch
St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. We are looking for a candidate to fill any of a number of roles in our highly interdisciplinary, collaborative environment, ranging from single-molecule fluorescence imaging of cells and biomolecules to photophysically-guided development of organic fluorophores. This requires a creative, team-oriented individual with strong leadership skills who is comfortable pursuing highly impactful scientific advances across a range of biological systems and disciplines. Experience with quantitative single-molecule biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. The role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.   Publication links: - Quantifying secondary transport at single-molecule resolution. - Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. - Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. - A partially-open inward-facing intermediate conformation of LeuT is associated with Na<sup>+</sup> release and substrate transport. - Aminoglycoside interactions and impacts on the eukaryotic ribosome. - Dynamics of P-type ATPase transport revealed by single-molecule FRET. - Miscoding-induced stalling of substrate translocation on the bacterial ribosome. - Single-molecule analysis of ligand efficacy in β<sub>2</sub>AR-G-protein activation. - Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging. - Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. - Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation. - Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. - Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. - Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. - Transport domain unlocking sets the uptake rate of an aspartate transporter. - Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. - Ultra-stable organic fluorophores for single-molecule research. - Allosteric control of the ribosome by small-molecule antibiotics. - Cyanine fluorophore derivatives with enhanced photostability. - Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. - Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
ID
43865
Department
Structural Biology
Faculty Member
Roger Altman
The Mefford lab is seeking a postdoctoral fellow in translational neuroscience to study genomic and epigenomic causes of pediatric epilepsy and related disorders. Project opportunities include: integrated analysis of genome and transcriptome data to identify novel causes of pediatric epilepsy; investigating epigenetic causes of epilepsy; and functional studies of genetic epilepsies using patient-derived stem cell models. 
ID
43835
Department
Center for Pediatric Neurological Disease Research
Faculty Member
Heather Mefford
Postdoctoral Fellowships in Omics, Cancer and Alzheimer’s Disease Research   Two postdoctoral positions are available for motivated candidates at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. Our group has contributed to the discovery of ubiquitin code (Cell 2009) and numerous novel pathways in Alzheimer’s disease (Neuron 2020). The successful applicant will have an opportunity to use a range of approaches, including mass spectrometry, single-cell proteomics, CRISPR and organoids to explore the pathogenesis of cancer or neurodegenerative diseases. The overarching aim is to study complex molecular interactions by chemistry, genetics and systems biology, providing novel insights into disease development, therapeutic intervention, and biomarker discovery for precision medicine (https://www.stjude.org/peng). Our postdoctoral fellows have extensive interaction with other members for career development in cutting-edge technologies and biomedical research. More than 10 alumni become principal investigators. Our publications are available on Google Scholar (200+ publications, 24,000+ citations). St. Jude is a top ranked hospital (#1 for pediatric cancer specialty in U.S. in 2017) and a world-class basic research institute with about 300 faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary (median $56,000) in an affordable city, a professional development allowance ($1,875), and an array of benefits, including sign-on bonus ($3,000), health, dental and vision coverage, and a retirement program.   Candidates must have an excellent publication record. Please submit CV, three references, a brief statement regarding previous work and future goals to Dr. Junmin Peng (junmin.peng@stjude.org), Member (Full Professor) in Departments of Structural Biology and Developmental Neurobiology, Director of Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital.
ID
43838
Department
Structural Biology
Faculty Member
Junmin Peng
A post-doctoral fellowship position is available in the laboratory of Dr. Jeffery Klco in the Department of Pathology at St Jude Children’s Research Hospital to study the development of myeloid tumors in children.  In particular, we are focused on the mechanisms of disease progression through the molecular characterization of different somatic and germline mutations in pediatric myeloid tumors, as well as the identification of vulnerabilities that may present unique therapeutic options. The experimental models include genetically-modified mice and the manipulation of primary hematopoietic cells, including cord blood CD34 cells and patient derived xenografts.
ID
43799
Department
Pathology
Faculty Member
Jeffery Klco

Stay connected

Not ready to apply? Become a St. Jude Career Insider to stay up-to-date on our opportunities.