Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

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Are you looking for stability and competive pay? Come make a difference with St. Jude Children's Research Hospital as a Catering Coordinator. We are committed and take pride within our Food Services Department when it comes to serving our patients, families, and employees. This is a great opportunity to grow your career and connect with our amazing customers.   Part-Time: Monday-Friday rotating time slots afternoons and evenings, and the availability to work weekends and holidays. Starting pay rate depends on years of experience but starts at $17.00/hr. and some benefits are offered.   Must be flexible and able to adopt to change and pass a MVR (Motor Vehicle Report) check.  
ID
46727
Department
Food Services
Faculty Member
Lisa Franklin
A postdoctoral position is currently available in the Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USA   The position available is within the NIAID-funded St. Jude Center of Excellence in Influenza Research and Response (SJCEIRR) Program which integrates comprehensive global influenza virus surveillance with fundamental research that provides insight into the mechanisms that foster pandemic influenza emergence at the human-animal interface. The members of the SJCEIRR team provide NIAID with experts who are integrated into the influenza programs of key international agencies such as the World Health Organization (WHO), the Food and Agriculture Organization of the United Nations, and the World Organization for Animal Health. The successful candidate will participate in a robust and highly productive program on antiviral research. Antiviral drugs are a critical line of defense against epidemic and emerging viruses, particularly when vaccines are unavailable. A central part of pandemic preparedness and response is understanding the susceptibility of emerging viruses to existing and new treatments. We seek to understand the efficacy, likelihood of resistance generation, and optimal treatment regiments of approved and investigational antivirals, particularly those targeting influenza viruses. Applicants should be prepared to work with investigators across multiple disciplines to conduct cutting edge research informing public health. The preferred candidate will be proficient with commonly utilized laboratory techniques in cell and molecular biology, tissue culture and mouse and ferret animal models.   Interested applicants should send their curriculum vitae, a one‐page description of research interests, and names and contact information of three references to: postdoc@stjude.org.  
ID
46671
Department
Infectious Diseases
Faculty Member
Richard Webby
The Cupido lab at St Jude Children Research Hospital (Memphis, TN) is seeking postdoctoral fellows who wish to conduct structural and chemical biology research and gain experience as independent researchers. These positions are core funded and the expected start date will be in January 2022 but can be flexible. About The Lab The Cupido Lab opened on January 2021 in the Department of Chemical Biology & Therapeutics, and is well equipped for biochemistry and chemical biology research. The Lab has also full access to unparalleled resources and expertise in an open environment at St Jude. Our research focuses on discovering drug-like chemical modulators for protein machines and for the analysis of molecular mechanisms that regulate the flow of genetic information (e.g. gene transcription and splicing). Our efforts are highly multidisciplinary, and combine small molecule chemistry with structural and genomic approaches. One major focus is to understand the mechanism and regulation of nucleic acid-interacting enzymes whose aberrant function is implicated in cancer development. We seek to control the dynamics of these protein machines, using chemicals we design, to identify and then test novel pharmacological approaches for treating cancer. To apply, please send a cover letter emphasizing research background and career goals, and a CV.
ID
46635
Department
Chemical Biology & Therapeutic
Faculty Member
Tommaso Cupido
Dr. Stan Pounds, a Member (Professor) in the St. Jude Department of Biostatistics, seeks a postdoc to pioneer the development and application of innovative data analysis methods in statistical cancer genomics and pharmacogenomics.  In close collaboration with Drs. Charles Mullighan (St. Jude Pathology Department) and Jatinder Lamba (University of Florida College of Pharmacy), the successful applicant will develop and apply innovative statistical methods that integrate multiple forms of omic data (genomic, epigenomic, transcriptomic, proteomic, metabolomic) with multiple clinical outcomes (initial response, relapse-free survival, overall survival) to make fundamental biological discoveries that accelerate our progress towards curing childhood leukemias.  
ID
46656
Department
Biostatistics
Faculty Member
Stanley Pounds
St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS).   Other benefits include: - Access to exceptional core facilities to help advance your research - Opportunity to obtain a Master of Public Health in epidemiology or biostatistics with full tuition - Opportunity to participate in St. Jude Global Pediatric Medicine conducting research in Central America, South America, Mexico, Eastern Mediterranean region, China, and Southeast Asia St. Jude offers highly competitive stipends and benefits and fosters professional development.   About St. Jude St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. It is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and is an Equal Opportunity Employer. For more information, visit www.stjude.org.
ID
46548
Department
Epidemiology & Cancer Control
Faculty Member
Kevin Krull
Postdoctoral Associate Position in Structural Biology    The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the mechanism of stress granule aging and its role in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. This project is part of a collaboration with Drs. J. Paul Taylor (St. Jude, HHMI) and Dr. Rohit Papu (Washington University in St. Louis).   The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, protein technology, and microscopy. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.   Contact Information  Tanja Mittag, PhD  Department of Structural Biology  St. Jude Children’s Research Hospital  262 Danny Thomas Place  Memphis, TN  38105-3678  E-mail: tanja.mittag@stjude.org  https://www.stjude.org/mittag   
ID
46513
Department
Collaborative Research Program
Faculty Member
Tanja Mittag
Please apply here, in addition to specific postings, if you would like your CV reviewed by multiple faculty. Also apply here if you have been requested to do so by a recruiter.
ID
APO22
Department
Academic Programs
Faculty Member
Laura Netten
Exploiting Water Network Perturbations in Protein Binding Sites   We are recruiting a postdoc for a computational structural biology project that investigates the role of water network at protein ligand interfaces with a view towards ligand discovery. The position is available immediately and NIH funded for 5 years.   We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein-ligand binding and leverage this information for ligand discovery. As this project integrates experimental and computational data it will require both a solid background in structural biology and significant computational skills for custom data analysis and automation. The project is embedded into a dynamic lab that has strong expertise in modulating protein conformational ensembles with ligands and temperature (see references below).   The project is housed in the Department of Chemical Biology and Therapeutics, and Structural Biology at St. Jude Children’s Research Hospital. It builds on strong investments into a world-class infrastructure in structural and chemical biology. This is an exciting time to join us and build a career while living in an affordable city. This postdoc position is NIH funded for 5 years.   Please direct your questions and application package including a cover letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (marcus.fischer@stjude.org).   Relevant papers include: - Bradford et al. (2021). Temperature artifacts in protein structures bias ligand-binding predictions. Chemical Science. DOI: 10.1039/D1SC02751D - Fischer (2021). Macromolecular room temperature crystallography. Q Rev Biophys 54. E1 - Darby et al. (2019). Water Networks Can Determine the Affinity of Ligand Binding to Proteins. JACS 141, 15818-26. - Balius et al. (2017). Testing inhomogeneous solvation theory in structure-based ligand discovery. PNASE6839-46. - Fischer et al. (2015). One crystal, two temperatures: cryocooling penalties alter ligand binding to transient protein sites. Chembiochem 1560-64. - Fischer et al. (2014). Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry 6, 575-83.   More info at: https://www.stjude.org/fischer
ID
46469
Department
Chemical Biology & Therapeutic
Faculty Member
Marcus Fischer
Postdoctoral Position in Developmental Neurobiology   A postdoctoral position is currently available in the Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, in the laboratory of Dr. Xinwei Cao. We study the molecular and cellular mechanisms that regulate the development of the vertebrate nervous system, with a special focus on neural stem/progenitor cells. We use transgenic and knockout models and employ an integrated set of molecular, cellular, biochemical, and imaging techniques.   Contact Information Xinwei Cao, PhD Associate Member Department of Developmental Neurobiology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN  38105-3678 Email: Xinwei.cao@stjude.org http://www.stjude.org/cao
ID
46477
Department
Developmental Neurobiology
Faculty Member
Xinwei Cao
St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS). Other benefits include: - Access to exceptional core facilities to help advance your research. - Opportunity to obtain a Master of Public Health in epidemiology or biostatistics with full tuition. - Opportunity to participate in St. Jude Global Pediatric Medicine conducting research in Central America, South America, Mexico, Eastern Mediterranean region, China, and Southeast Asia. St. Jude offers highly competitive stipends and benefits and fosters professional development.   St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. It is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.  St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and is an Equal Opportunity Employer. For more information, visit www.stjude.org.   To learn more, please contact: Kevin Krull, PhD Department of Epidemiology and Cancer Control St. Jude Children’s Research Hospital kevin.krull@stjude.org
ID
46441
Department
Epidemiology & Cancer Control
Faculty Member
Kevin Krull
A bioinformatics postdoctoral position is available in the Savic laboratory to study the pharmacogenomics of treatment in childhood leukemia. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies various orthogonal functional genomic assays and high-throughput screening approaches to identify and functionally characterize genetically and/or epigenetically disrupted cis-regulatory elements impacting childhood leukemia pharmacogenomics. The long-term goal of the Savic laboratory is to gain a better understanding of the genetic and epigenetic underpinnings of chemotherapeutic drug resistance and relapse in childhood leukemia.
ID
46338
Department
Pharmaceutical Sciences
Faculty Member
Daniel Savic
A postdoctoral researcher position is available in Dr. Yong Feng’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital.  Research in Dr. Feng’s laboratory is utilizing innovative approaches and cutting-edge technologies to decipher the mechanisms governing T cell immune tolerance.   Besides the unmatched benefit for postdoctoral fellows at St. Jude Children’s Research Hospital, the extraordinary internal support and state-of-the-art facilities provide an exceptional environment to train the next generation of biomedical investigators.  In addition to applying, a cover letter of interest, CV and three recommendation letters should be sent to Yong.Feng@STJUDE.ORG
ID
46351
Department
Immunology
Faculty Member
Yongqiang Feng
Dr. Zhaoming Wang, a joint faculty member between St. Jude Department of Epidemiology and Cancer Control and the Department of Computational Biology, is seeking highly motivated and creative candidates for a fully supported postdoctoral fellow position to conduct high impact clinical research primarily in genetic epidemiology of cancers (childhood and subsequent adulthood cancers), biomarker discovery for treatment- and/or aging-related late effects of survivors of childhood cancer, and omics-based precision preventive medicine.   You will have the opportunity to work with large-scale whole-genome sequencing, whole-exome sequencing, epigenetic profile, and RNA sequencing data for a well-established cohort of childhood cancer survivors with clinically assessed rich set of phenotypes including subsequent neoplasms.   In this position, you will gain extensive experience and training in genetic and molecular epidemiology, as well as programming skills and analytic expertise in computational biology. You will be provided with opportunities to work within a multi-disciplinary research environment and interact with leaders in the fields of pediatric cancer, genetics, epigenetics, functional genomics, and survivorship research. The training position is supported by a V-Foundation grant for conducting social epigenomics studies in adult survivors of childhood cancer.
ID
46329
Department
Epidemiology & Cancer Control
Faculty Member
Zhaoming Wang
We seek a highly motivated postdoctoral research associate to join the group of Dr. Mario Halic in the Department of Structural Biology at St. Jude Children's Research Hospital.   The Halic lab studies the epigenetic regulation of gene expression using genetics, molecular biology, biochemistry and structural biology approaches. In particular, we study heterochromatin formation and the chromatin-modifying proteins involved in this process. We use cryo-EM methodologies to examine processes involved in chromatin organization and also apply genetics and molecular biology approaches to investigate heterochromatin formation in fission yeast. More information about the lab, publications and ongoing projects can be found here: https://www.stjude.org/research/labs/halic-lab.html   This is an excellent opportunity for an early-career scientist to broaden their skill set. You will join a vibrant community at the Department of Structural Biology at St. Jude Children's Research Hospital, with access to state-of-the-art facilities that enable integrative structural biology and biophysics investigations, including cryo-EM, X-ray crystallography and NMR, single-molecule imaging, protein-protein interactions, combined with computational and data-science approaches. More information about the department can be found here: https://www.stjude.org/research/departments/structural-biology.html   St. Jude Children’s Research Hospital has a highly collaborative research environment, with numerous institutional shared resources and core facilities. In addition, postdocs benefit from excellent salary and benefits package: https://www.stjude.org/education-training/advanced-training/postdoctoral-fellows/funding-benefits-for-postdocs.html   Applicants should submit CV and cover letter (describing research experience and interests) and names and addresses for 3 references.
ID
46108
Department
Structural Biology
Faculty Member
Mario Halic
Postdoctoral Researcher in HPV Cancer Prevention   APPLY here for the Postdoctoral Researcher.   St. Jude Children's Research Hospital is leading the way the world understands, treats, and defeats childhood cancer and other childhood diseases. Our mission, to advancecures, and means for prevention, for pediatric catastrophic diseases through research and treatment, is at the center of our work and everything we do. We are a great place to work, consistently ranked among Fortune Magazine’s 100 Best Places to Work For®. At St. Jude, employees are encouraged to contribute new ideas, no matter who you are or what you do, to make the organization the best it can be.   We are seeking two outstanding candidates for postdoctoral fellowship positions in the HPV Cancer Prevention Program at St. Jude Children’s Research Hospital. The postdoctoral positions offer an intensive, mentored training experience in implementation science, community-engaged research, health equity, and cancer prevention through HPV vaccination. Postdoctoral fellows will be encouraged to support the research foci of the HPV Cancer Prevention Program and develop their own research programs in implementation science with a specific focus on HPV vaccination or other related topics (e.g., health equity, partner and engaged research approaches, building vaccine confidence, supporting vaccinations in clinical and community settings, public policy and advocation, communications, etc.) using implementation science frameworks.   To apply or learn more, please contact: Heather M. Brandt, PhD Director, HPV Cancer Prevention Program Member, Department of Epidemiology and Cancer Control Department of Epidemiology and Cancer Control St. Jude Children’s Research Hospital Heather.Brandt@stjude.org   Learn more about the HPV Cancer Prevention Program at stjude.org/hpv.  
ID
44854
Department
HPV Cancer Prevention
Faculty Member
Heather Brandt
St. Jude Children's Research Hospital is leading the way the world understands, treats, and defeats childhood cancer and other childhood diseases. Our mission, to advancecures, and means for prevention, for pediatric catastrophic diseases through research and treatment, is at the center of our work and everything we do. We are a great place to work, consistently ranked among Fortune Magazine’s 100 Best Places to Work For®. At St. Jude, employees are encouraged to contribute new ideas, no matter who you are or what you do, to make the organization the best it can be.   We are seeking two outstanding candidates for postdoctoral fellowship positions in the HPV Cancer Prevention Program at St. Jude Children’s Research Hospital. The postdoctoral positions offer an intensive, mentored training experience in implementation science, community-engaged research, health equity, and cancer prevention through HPV vaccination. Postdoctoral fellows will be encouraged to support the research foci of the HPV Cancer Prevention Program and develop their own research programs in implementation science with a specific focus on HPV vaccination or other related topics (e.g., health equity, partner and engaged research approaches, building vaccine confidence, supporting vaccinations in clinical and community settings, public policy and advocation, communications, etc.) using implementation science frameworks.   To apply or learn more, please contact: Heather M. Brandt, PhD Director, HPV Cancer Prevention Program Member, Department of Epidemiology and Cancer Control Department of Epidemiology and Cancer Control St. Jude Children’s Research Hospital Heather.Brandt@stjude.org   Learn more about the HPV Cancer Prevention Program 
ID
44855
Department
HPV Cancer Prevention
Faculty Member
Heather Brandt
St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in infectious disease therapeutics. This NIH sponsored training program has been designed to leverage the outstanding research infrastructure at St. Jude to train top-tier postdoctoral fellows with the necessary skills to lead independent research programs in the discovery of infectious diseases therapeutics including small molecule and vaccine candidates.   Postdoctoral preceptors associated with the program are drawn from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences, bringing complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them. This expertise includes structural biology, virology and bacteriology, microbial genomics, drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants. All trainees will be instructed in grant writing, rigor and reproducibility, ethics and mentoring. Short-term internships in pharmaceutical companies or visits to international clinical sites in conjunction with the SJCRH Global Program are integral parts of the curriculum. Collaborations between the preceptors is encouraged to provide a cross-disciplinary approach to the training program. St. Jude offers highly competitive stipends and benefits and fosters professional development.
ID
44989
Department
Academic Programs
Faculty Member
Stephen White
Overview   Outstanding candidates are invited to apply for a medical physics postdoctoral research associate in  the Department of Radiation Oncology at St. Jude Children’s Research Hospital. In this two-year position, you will benefit from world-class resources and exceptional training in a top-ranked research environment while helping to advance treatment options for children with cancer.   Research Focus   The primary focus of this postdoctoral research associate position is on using Big Data analytics tools to improve treatment plan quality in proton therapy. We are especially interested in understanding the roles of linear energy transfer and treatment plan robustness. Research aims include the following:   - Contributing to data infrastructure efforts by reviewing clinical treatment plans, analyzing Monte Carlo dose distributions, and using good data practices   - Testing and validating novel analytics tools on curated data sets to better understand radiation therapy outcomes of children with cancer   - Investigating ways in which artificial intelligence may contribute to improving outcomes models   St. Jude offers a collaborative research environment and exceptional support for scientific discovery. The successful candidate will work closely with the principal investigators, computational scientists, and students in the research group. The postdoctoral research associate will interact with radiation oncologists, information technology support staff, clinical therapy and physics staff, and clinical scientists. Research activities will include data collection, image analysis, dosimetry comparisons with treatment planning systems and Monte Carlo calculations, experimental validation with proton beams, and report and manuscript preparation. Opportunities to gain clinical experience in proton and photon radiotherapy physics may be made available pending adequate research progress.   Resources and Equipment   As part of the Department of Radiation Oncology, the postdoctoral research associate will have access to world-class resources, including the world’s first proton therapy center with pencil-beam scanning technology that is designated solely for treating pediatric cancer, a detector-based spectral CT scanner that was the first in the world to be installed in a radiation oncology department, state-of-the-art 1.5T and 3T MR scanners, and a recently installed digital PET/CT scanner. The department also has a full suite of radiation oncology software, including Eclipse, RayStation, and Pinnacle treatment planning systems and MiM Maestro.   Contact Information   Austin M. Faught, PhD, DABR Assistant Member, Department of Radiation Oncology 262 Danny Thomas Place Memphis, TN 38105 E-mail: austin.faught@stjude.org | Web: www.stjude.org/faught
ID
44951
Department
Radiation Oncology
Faculty Member
Austin Faught
POSTDOCTORAL POSITION to study the function of novel CAR T cell-based therapies for pediatric brain tumors   St. Jude Children's Research Hospital, Memphis, Tennessee, USA We are seeking a highly motivated and ambitious postdoctoral fellow to join the group of Dr. Giedre Krenciute. The lab is located in the Department of Bone Marrow Transplantation and Cellular Therapy at St. Jude Children’s Research Hospital in Memphis, TN. Our lab is working on highly translational immunology research, with the focus on brain tumors. We use genetically engineered human or murine T cells to design novel, long-lasting and safe therapeutic approaches for pediatric brain tumors.   Major projects include: - Designing, generating, and optimizing chimeric antigen receptors (CARs) specific for pediatric brain tumors. - Enhancing CAR T cell effector function and longevity using different genetic manipulations - Studying brain tumor microenvironment and its effect on CAR T cell function   For representative publications, please see: Haydar D, Houke H, Chiang J, Yi Z, Odé Z, Caldwell K, Zhu X, Mercer KS, Stripay JL, Shaw TI, Vogel P, DeRenzo C, Baker SJ, Roussel MF, Gottschalk S, KrenciuteG. Cell surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery. Neuro Oncol. 2020 Prinzing B, Schreiner P, Bell M, Fan Y, Krenciute G*, Gottschalk S*. MyD88/CD40 signaling retains CAR T cells in a less differentiated state. JCI Insight. 2020. *co-senior authors Odé Z, Condori J, Peterson N, Zhou S, Krenciute G. CRISPR-Mediated Non-Viral Site-Specific Gene Integration and Expression in T Cells: Protocol and Application for T-Cell Therapy. Cancers (Basel). 2020 Yi Z, Brooke LP, Cao F, Gottschalk S, Krenciute G. Optimizing EphA2-CAR T cells for the Adoptive Immunotherapy of Glioma. Molecular Therapy - Methods & Clinical Development. 2018 Krenciute G, Prinzing BL, Yi Z, Wu MF, Liu H, Dotti G, Balyasnikova IV, Gottschalk S. Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen-loss variants. Cancer Immunol Res. 2017   Interested applicants should send their CV, a cover letter describing research experience and interests, and names and email addresses of three references to: giedre.krenciute@stjude.org
ID
44927
Department
Bone Marrow Trans & Cell Thrpy
Faculty Member
Giedre Krenciute
POSTDOCTORAL POSITION to study the function of novel CAR T cell-based therapies for pediatric brain tumors   St. Jude Children's Research Hospital, Memphis, Tennessee, USA We are seeking a highly motivated and ambitious postdoctoral fellow to join the group of Dr. Giedre Krenciute. The lab is located in the Department of Bone Marrow Transplantation and Cellular Therapy at St. Jude Children’s Research Hospital in Memphis, TN. Our lab is working on highly translational immunology research, with the focus on brain tumors. We use genetically engineered human or murine T cells to design novel, long-lasting and safe therapeutic approaches for pediatric brain tumors.   Major projects include: - Designing, generating, and optimizing chimeric antigen receptors (CARs) specific for pediatric brain tumors. - Enhancing CAR T cell effector function and longevity using different genetic manipulations - Studying brain tumor microenvironment and its effect on CAR T cell function   For representative publications, please see: Haydar D, Houke H, Chiang J, Yi Z, Odé Z, Caldwell K, Zhu X, Mercer KS, Stripay JL, Shaw TI, Vogel P, DeRenzo C, Baker SJ, Roussel MF, Gottschalk S, KrenciuteG. Cell surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery. Neuro Oncol. 2020 Prinzing B, Schreiner P, Bell M, Fan Y, Krenciute G*, Gottschalk S*. MyD88/CD40 signaling retains CAR T cells in a less differentiated state. JCI Insight. 2020. *co-senior authors Odé Z, Condori J, Peterson N, Zhou S, Krenciute G. CRISPR-Mediated Non-Viral Site-Specific Gene Integration and Expression in T Cells: Protocol and Application for T-Cell Therapy. Cancers (Basel). 2020 Yi Z, Brooke LP, Cao F, Gottschalk S, Krenciute G. Optimizing EphA2-CAR T cells for the Adoptive Immunotherapy of Glioma. Molecular Therapy - Methods & Clinical Development. 2018 Krenciute G, Prinzing BL, Yi Z, Wu MF, Liu H, Dotti G, Balyasnikova IV, Gottschalk S. Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen-loss variants. Cancer Immunol Res. 2017   Interested applicants should send their CV, a cover letter describing research experience and interests, and names and email addresses of three references to: giedre.krenciute@stjude.org
ID
44929
Department
Bone Marrow Trans & Cell Therapy
Faculty Member
Giedre Krenciute

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