Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

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A postdoctoral (Scientist) position is available immediately in the Chang lab in the Department of Cell & Molecular Biology at St. Jude Children’s Research Hospital.  We are looking for highly talented, self-motivated individuals passionate about how cells function as integrated units. In particular, the candidate will utilize cutting-edge light and electron microscopy tools together with genome-editing, biochemistry and in vitro reconstitution to interrogate the fundamental questions of inter-organelle communication. Prerequisites are creativity, dedication, and the ability to work collaboratively in a small group.    Interested applicants should send a CV, cover letter describing why they are interested in working in our lab, and the names and address of 3 references to Chi-Lun.Chang@stjude.org.
ID
44459
Department
Cell & Molecular Biology
Faculty Member
Chi-Lun Chang
POSTDOCTORAL FELLOWSHIP POSITION IN COMPUTATIONAL NEUROSCIENCE St. Jude Children’s Research Hospital, Memphis, Tennessee Postdoctoral fellowship positions are available for highly motivated individuals interested in one of the following projects:   - synaptic and neuronal mechanisms in schizophrenia (with focus on mouse models of 22q11 deletion syndrome);  - plasticity in the auditory cortex (imaging of neuronal activity in awake mice); - synaptic and neuronal deficits in Williams-Beuren syndrome (with focus on the auditory cortex and amygdala in mice).   The fellow will benefit from both the outstanding work environment in the laboratory and the highly collaborative St. Jude community. The successful candidate will join a diverse team of researchers whose effort is to understand behavior at the levels of neural circuits, individual neurons, synapses, and molecules. The laboratory is a part of the Department of Developmental Neurobiology. Members have access to specialized departmental shared resources, including an integrated support structure for rodent behavior testing, 3-dimensional brain organoids, in vivo and ex vivo cellular imaging, bioinformatics, production of genetically engineered animal models, single-cell profiling, and advanced image processing and analysis. In addition, numerous institutional shared resources and core facilities support the laboratory by providing expertise and state-of-the-art technologies. The lab is equipped to perform single-cell electrophysiology, two-photon imaging, and two-photon glutamate uncaging in brain slices and in awake behaving animals.         St. Jude Children’s Research Hospital offers an excellent salary and benefits package and is an equal opportunity employer.   Interested applicants should apply at the following link Job 44453   Contact Information Stanislav Zakharenko, M.D., Ph.D. Department of Developmental Neurobiology, MS 322 St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN 38105 stanislav.zakharenko@stjude.org https://www.stjude.org/zakharenko
ID
44453
Department
Developmental Neurobiology
Faculty Member
Stanislav Zakharenko
We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children's Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries.  We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors. For more details, please visit https://www.stjude.org/sun or directly contact Dr. Ji Sun (ji.sun@stjude.org).
ID
44434
Department
Structural Biology
Faculty Member
Ji Sun
We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children's Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins and protein machineries.  We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins and protein complexes (Sun, NSMB 2020; Sun and Mackinnon, Cell 2020; Sun and MacKinnon, Cell 2017). The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscopes, both equipped with K3 detectors. For more details, please visit https://www.stjude.org/sun or directly contact Dr. Ji Sun (ji.sun@stjude.org).
ID
44435
Department
Structural Biology
Faculty Member
Ji Sun
A postdoctoral position isavailable in the Derecka Lab in the Department of Hematology at St. Jude Children’s Research Hospital to study transcriptional regulation of the bone marrow niche. The major research goal of our group is to gain mechanistic insights into cellular cross communication between bone marrow microenvironment and hematopoietic compartment, in steady state and pathophysiological conditions. You will have the opportunity to develop new exciting projects involving changes of bone marrow microenvironment and its impact on aging blood system; transcriptional dysregulation of bone marrow niche in hematological disorders and bone marrow niche-induced changes of chromatin landscape in hematopoietic progenitors. In this position, you will have a chance to lead your projects and mature into fully independent researcher. Successful candidate will gain an experience in genome wide technology, CRISPR-Cas editing, mouse models and stem cell biology. St. Jude offers a cutting-edge scientific and training environment, combining both clinical and basic research. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
44314
Department
Hematology
Faculty Member
Marta Derecka
A fully funded postdoctoral position is immediately available Mark Hatley’s laboratory in the Molecular Oncology Division of the Department of Oncology at St. Jude Children’s Hospital. The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our recent findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018). We now seek to elucidate the mechanism of this cell reprogramming event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as induced pluripotent stem cells as model systems to interrogate the underlying pathobiology of pediatric rhabdomyosarcoma.   The Hatley lab is a very collaborative, interactive environment focused on scientific and career development of trainees. The lab supports a healthy work/life balance and diversity with a focus on career development. Dr. Hatley was the 2019 mentor of the year at St. Jude. Successful applicants should have strong organizational and communication skills with drive and dedication to participate as a member of our team.
ID
44285
Department
Oncology
Faculty Member
Mark Hatley
A fully funded postdoctoral position is immediately available in the Weiss/Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a candidate that are interested in therapeutic genome editing using next generation genome editors such as Base Editor or Prime editors. The candidate will study the interplay between genome editors and different types blood cells (such HSCs, other progenitors and erythroid cells) and develop and optimize novel treatment for genetic blood disorders. In this position, the candidate will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study. St. Jude Children’s Research Hospital is a top-ranked Pediatric Cancer Hospital and a world-renowned basic science research institute with over 200 faculty members. St. Jude offers a highly collaborative research and training environment that includes state-of-the-art facilities and resources. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
44222
Department
Hematology
Faculty Member
Mitchell Weiss
A fully funded postdoctoral position is immediately available Mark Hatley’s laboratory in the Molecular Oncology Division of the Department of Oncology at St. Jude Children’s Hospital. The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our recent findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018). We now seek to elucidate the mechanism of this cell reprogramming event and its role in cell transformation. The lab leverages genetically engineered mouse models, patient-derived xenografts, human and mouse tumor and primary cell lines as well as induced pluripotent stem cells as model systems to interrogate the underlying pathobiology of pediatric rhabdomyosarcoma.   The Hatley lab is a very collaborative, interactive environment focused on scientific and career development of trainees. The lab supports a healthy work/life balance and diversity with a focus on career development. Dr. Hatley was the 2019 mentor of the year at St. Jude. Successful applicants should have strong organizational and communication skills with drive and dedication to participate as a member of our team.
ID
44240
Department
Oncology
Faculty Member
Mark Hatley
The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer.  The project will include assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.
ID
44212
Department
Immunology
Faculty Member
Benjamin Youngblood
Postdoctoral Associate Position in Structural Biology    The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the role of liquid-liquid phase separation in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. Data will be interpreted through a polymer physics lense and supplemented through simulations via a collaboration with Dr. Rohit Papu’s laboratory at Washington University in St. Louis.   The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.       Contact Information  Tanja Mittag, PhD  Department of Structural Biology  St. Jude Children’s Research Hospital  262 Danny Thomas Place  Memphis, TN  38105-3678  E-mail: tanja.mittag@stjude.org  https://www.stjude.org/mittag 
ID
44201
Department
Structural Biology
Faculty Member
Tanja Mittag
St. Jude Children’s Research Hospital are seeking highly motivated candidates to join the laboratory of Dr. Chia-Hsueh Lee in the Department of Structural Biology as a postdoctoral fellow to lead exciting research initiatives. The lab use cryo-EM and a range of biochemical/biophysical methods to study the function of membrane proteins (e.g. Wang et al., NSMB 2021; Lee and MacKinnon, Cell, 2019; Lee and MacKinnon, Science, 2018).   The lab has frequent access to the state-of-the-art cryoEM facility at St. Jude, which houses a 300kV Titan Krios, a 200kV Arctica, and a 120kV Talos L120C microscope. We are looking for an individual who have a passion for learning and navigating new research fields and is comfortable pursing highly impactful scientific advances.
ID
44202
Department
Structural Biology
Faculty Member
Chia-Hsueh Lee
St. Jude Children’s Research Hospital are seeking highly motivated candidates to join the laboratory of Dr. Chia-Hsueh Lee in the Department of Structural Biology as a postdoctoral fellow to lead exciting research initiatives. The lab use cryo-EM and a range of biochemical/biophysical methods to study the function of membrane proteins (e.g. Wang et al., NSMB 2021; Lee and MacKinnon, Cell, 2019; Lee and MacKinnon, Science, 2018).   The lab has frequent access to the state-of-the-art cryoEM facility at St. Jude, which houses a 300kV Titan Krios, a 200kV Arctica, and a 120kV Talos L120C microscope. We are looking for an individual who have a passion for learning and navigating new research fields and is comfortable pursing highly impactful scientific advances.
ID
44203
Department
Structural Biology
Faculty Member
Chia-Hsueh Lee
St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine. The institution has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients.   The Department of Structural Biology is seeking a photochemist to help lead theoretical and design aspects of our ongoing fluorophore synthesis and photophysics research in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also help lead chemical biology initiatives aimed at advancing mechanistic studies of clinically important biological systems at the single-molecule scale. The lab’s highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.   Training opportunity and responsibilities - Photophysical characterizations (steady-state and time-resolved) of cyanine- and rhodamine-class organic fluorophores at both ensemble and single-molecule levels. - Electrochemical characterizations of cyanine- and rhodamine-class organic fluorophores. - Collaboratively designed quantum chemical calculations. - Mechanistic understanding of photophysics of cyanine- and rhodamine-class organic fluorophores. - Generate hypotheses-driven design strategies in collaboration with our chemistry team. - Presentation of experimental data and research progress in collaborative, cross-disciplinary settings. - Effectively communicate and help advance multidisciplinary team-based research projects. - Follow safety guidelines and contribute to the maintenance of spectroscopy equipment.
ID
44170
Department
Structural Biology
Faculty Member
Roger Altman
The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how acquired mutations in hematopoietic stem cells lead to the development of clonal hematopoiesis and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.   You will have the opportunity to develop and lead projects using several cutting-edge model systems including:   - Isogenic immortalized cell lines generated using CRISPR-Cas gene editing - Novel xenograft and transgenic in vivo systems - Primary patient samples   In this position, you will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study development.   St. Jude Children’s Research Hospital is a top-ranked Pediatric Cancer Hospital and a world-renowned basic science research institute with over 200 faculty members. St. Jude offers a highly collaborative research and training environment that includes state-of-the-art facilities and resources. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance. 
ID
44136
Department
Oncology
Faculty Member
Esther Obeng
Dr. Martine F. Roussel, Department of Tumor Cell Biology, has two exciting new postdoc positions available in her laboratory.   Project 1. MYCN is overexpressed in a variety of childhood cancers, and aberrant MYCN expression is universally associated with a highly aggressive clinical phenotype, metastatic dissemination and low survival rates. The selected postdoc will play a major role in an integrated and multidisciplinary effort to discover and develop PROTACs that will directly degrade the MYCN protein in pediatric solid tumors.   Project 2. Develop novel targeted protein degradation approaches to selectively degrade key oncogenic transcription factors in high risk childhood leukemia and medulloblastoma, two of the leading causes of childhood cancer death. Phenotypic and targeted screening approaches, along with robust computational and structural biology analyses, will be employed to identify and develop molecular glues that will selectively degrade multiple transcription factors. If successful, new therapeutic options for subtypes of pediatric cancers may be identified, and this could lead to further development of therapies to treat many hitherto undruggable cancers.   Project 3. Understand the role of histone methyltransferases in MYC-driven Group3 medulloblastoma, the most aggressive form of this pediatric cerebellar disease.  High throughput screens of epigenetic regulators using CRISPR-Cas9 gene editing and shRNA identified several chromatin regulators including two histone methyltransferases that regulate MYC expression and antagonize each other.  Biomedical and molecular analysis will unravel how these proteins drive medulloblastoma development and progression.  Inhibitors developed against these epigenetic regulators might be potential therapeutic targets that will be tested in pre-clinical trials using mouse models and patient-derived xenografts.   Project 4.  To target the p53 pathway in atypical thyroid/rhabdoid tumors (ATRTs).  ATRTs are aggressive pediatric brain tumors that occur in very young children for whom novel therapies are warranted.  We propose to conduct pre-clinical trials inpatient-derivedorthotopicxenograft(PDOX)modelsofATRTto study the effect of compounds that target the p53 pathway in combination with radiation.   If interested, please contact Dr. Roussel by email at martine.roussel@stjude.org.
ID
44109
Department
Tumor Cell Biology
Faculty Member
Martine Roussel
A Postdoctoral research position is available in the Department of Immunology at St Jude Children’s Research Hospital.  The research fellow will broadly study the role of epigenetic programming during development of functional and non-functional virus and tumor-specific CD8 T cells.  Specific emphasis will be focused on epigenetic programming in antigen-specific CD8 T cells from murine and human model systems.
ID
44068
Department
Immunology
Faculty Member
Benjamin Youngblood
A fully funded postdoctoral position is immediately available in the Cheng lab in the Department of Hematology at St. Jude Children’s Research Hospital. We are looking for a highly motivated candidate to investigate the genetic factors underpinning key human blood cell traits, particularly the functional impacts of non-coding regulatory elements during normal blood development and disorders.   https://www.stjude.org/directory/c/yong-cheng.html
ID
44042
Department
Hematology
Faculty Member
Yong Cheng
St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development. Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS). Other benefits include: - Access to exceptional core facilities to help advance your research. - Opportunity to obtain a Master of Public Health in epidemiology or biostatistics with full tuition. - Opportunity to participate in St. Jude Global Pediatric Medicine conducting research in Central America, South America, Mexico, Eastern Mediterranean region, China, and Southeast Asia. St. Jude offers highly competitive stipends and benefits and fosters professional development.   St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. It is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.  St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and is an Equal Opportunity Employer. For more information, visit www.stjude.org.
ID
44025
Department
Academic Programs
Faculty Member
Kevin Krull
The Yang Lab in the Department of Pharmaceutical Sciences and the Yu Lab in the Department of Computational Biology are jointly recruiting a highly motivated postdoctoral research associate to work on systems biology projects related to pediatric leukemia. Our labs are interested in developing and implementing novel computational biology tools, including NetBID (Gocho et al., Nature Cancer 2021), by integrating multi-omics data at both bulk and single-cell levels, to dissect the signaling circuitry related to leukemia biology and drug response. The candidate will work along with pharmacologists, cancer biologists, and clinicians to analyze large-scale genomic datasets and to identify molecular drivers for a variety of leuekmia phenotypes, to develop novel therapy for children with this cancer. The successful applicant will work in a dynamic and productive environment with exposure to research from basic biology, preclinical drug evaluation, to clinical trial development.   As one of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the infrastructure in our labs with the goal of providing postdocs flexibility and freedom to develop their research programs.   St. Jude provides a highly interactive and supportive environment for researchers’ career development and has been named to Glassdoor’s Best Places to Work 2018. St. Jude is a top-ranked hospital (#1 for pediatric cancer specialty in the U.S. in 2017) and a world-class basic research institute with 260+ faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary in an affordable city, a professional development allowance ($1,875), and an array of benefits, including sign-on bonus, health, dental and vision coverage, and a retirement program.   Interested candidates, please complete the online application and email your CV and cover letter to jun.yang@stjude.org
ID
43961
Department
Pharmaceutical Sciences
Faculty Member
Jun Yang
The group of Assistant Professor Tommaso Cupido at St Jude Children's Research Hospital (Memphis, TN) is seeking a highly motivated postdoctoral researcher to develop and apply cutting edge chemical biology and structural approaches for studying gene expression regulation by protein machines, at the molecular level.   A major focus of the lab is to understand the mechanism and regulation of nucleic acid-interacting enzymes, whose aberrant function is implicated in cancer development and resistance to chemotherapy. Our efforts are highly multidisciplinary, centered on small molecule chemistry and integrating biochemistry, structural biology, genomics, as well as systems biology.   Applications should include a letter of motivation stating research interests and expertise, a CV, and two references' contact information.
ID
43929
Department
Chemical Biology & Therapeutic
Faculty Member
Tommaso Cupido

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