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The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer. The project will included assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.
A postdoctoral fellowship is available immediately in the laboratory of Dr. Alessandra d’Azzo in the Department of Genetics. We are seeking a highly motivated postdoctoral scientist to study biological mechanisms involved in neurodegeneration associated with premature aging. The d’Azzo lab uses animal models of pediatric lysosomal storage diseases to dissect mechanisms of pathogenesis downstream of lysosomal enzymes and their substrates that result in loss in neural cell proteostasis, and parallel adult neurodegenerative conditions of protein aggregation, such as Alzheimer’s disease. The candidate must have a strong background in molecular and cell biology, specifically in neurobiology.
Two postdoctoral positions to study the molecular and cellular mechanism of brain development and cancer are available at the St. Jude Children’s Research Hospital in Memphis, TN, USA. The neocortex, the seat of complex behavior, cognition, and intellect, is tremendously expanded and folded in certain mammals including humans. However, little is known about the mechanisms underlying this neocortical expansion and folding (gyrencephaly). We have shown that Hedgehog signaling promotes gyrencephaly and generated the first transgenic murine model for gyrencephaly, where the small and smooth murine neocortex becomes large and folded one with anatomical and developmental hallmarks of gyrencephalic brains (Wang et al., Nature Neuroscience, 2016). We also use human cerebral organoids and a naturally gyrencephalic model organism, to extend our findings in murine models to naturally gyrencephalic species. Using these models we identified several genes that may play key roles in expansion and folding of the neocortex. We seek candidates who will (1) study the function of these identified genes in neocortical expansion and folding or (2) investigate the development and function of expanded and folded cortical area in a mutant murine model at the cellular, anatomical, physiological, and behavioral levels.
Another research focus is the function of primary cilia and Hedgehog signaling in cancer. Primary cilia play critical roles in multiple signaling pathways and cell cycle progression. We have shown that primary cilia can either promote or prevent cancer depending on the initiating oncogenic mutation (Han et al., Nature Medicine 2009). Recently, we showed that Hedgehog signaling controls protein translation through an mTORC1/4EBP1-dependent pathway and mTORC1 can be targeted to treat medulloblastoma, the most common pediatric brain cancer (Wu et al., Dev Cell in press, DOI). Currently, we are investigating the molecular and cellular mechanism of ciliary function in medulloblastoma and the function of translational targets of Hedgehog signaling in medulloblastoma.
A postdoctoral fellowship is available immediately in the laboratory of Dr. Alessandra d’Azzo in the Department of Genetics. We are seeking a highly motivated postdoctoral scientist to study biological mechanisms involved in tumor progression and metastasis with special interest in tumor microenvironment. The d’Azzo lab uses animal models of pediatric lysosomal storage diseases to dissect mechanisms of pathogenesis downstream of lysosomal enzymes that are implicated in aging and other adult diseases such as cancer. The candidate must have a strong background in molecular and cell biology, specifically in cancer biology.
Postdoctoral fellow positions are available in the Kalodimos lab in the Structural Biology department at St Jude Children’s Research Hospital. We are seeking highly motivated researchers to study large and dynamic macromolecular complexes by NMR spectroscopy. Biomolecular systems currently studied in the lab include molecular chaperones, protein kinases, protein secretion and translocation pathways, membrane receptor proteins and several multi-protein complexes. The NMR center at St Jude is outstanding and includes three 600 MHz, two 700 MHz, 800 MHz, and a 850 MHz. The first 1.1 GHz in the world is scheduled to be delivered early next year. Ample opportunities for employing and training in other technologies such as cryo-EM and X-ray crystallography will be available.
A postdoctoral researcher position is immediately available in Dr. Rhea Sumpter, Jr.’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital. Studies in Dr. Sumpter’s laboratory utilize innovative approaches and cutting-edge technologies to decipher the role of Fanconi anemia pathway proteins in selective autophagy, which is an ancient cell biology pathway that removes unwanted cytoplasmic constituents (e.g. intracellular pathogens, damaged organelles, protein aggregates) and delivers them to lysosomes for destruction. Defects in the autophagy pathway have been linked to numerous pathologies, including increased susceptibility to infectious and autoinflammatory diseases, cancer, metabolic disorders, and aging. We are focused on investigating the links between selective autophagy mediated by Fanconi anemia pathway proteins and host defense against viral infection, mitochondrial quality control, regulation of inflammasome signaling, bone marrow failure, and leukemogenesis. These studies will result in the discovery of the novel players and concepts that will deepen our understanding of the role of selective autophagy in health and disease, and may lead to new therapeutic targets for Fanconi anemia patients as well as for patients affected by the many other diseases in which the functioning of the autophagy pathway is impaired.
The Department of Epidemiology and Cancer Control at St. Jude Children's Research Hospital is seeking a postdoctral fellow to work in the intersection of computational and biological sciences, analyzing whole genome sequencing data of over 3000 childhood cancer survivors to predict late adverse outcomes among them. The position is funded by a 5-yr NIH grant (which is in its 1st year currently). The fellow will work in a highly collaborative environment with computational, biological, clinical, and population scientists at St. Jude, utilizing the existing (i.e., ready to be analyzed), high-quality, exceptionally strong data on genome, treatment exposures, and clinically/laboratory ascertained phenotypes to lead his/her projects for high-impact publications. The department and hospital are known for its excellence and the fellow will be mentored by the interdisciplinary faculty.
A postdoctoral fellowship is available in the laboratory of Dr. Charles Roberts in the Department of Oncology. Dr. Roberts’ lab studies the epigenetic regulation of gene expression. In particular we are studying chromatin-modifying proteins with a major focus on the SWI/SNF (BAF) chromatin remodeling/tumor suppressor complex and its relationship to cancers. Recent studies have revealed that genes encoding subunits of the SWI/SNF complex are mutated in over 20% of all cancers, a rate approaching that of p53, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanism by which SWI/SNF complex contributes to the regulation of gene expression and lineage specification, and the mechanisms by which mutation of the tumor suppressor subunits drives cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. We seek an ambitious postdoctoral scientist with a strong background in molecular biology, cell biology, cancer biology, and/or genetics/epigenetics of tumorigenesis. Currently there are several projects ongoing in the laboratory involving the use of a variety of model systems that have been engineered in the lab including mouse models, primary cells, and cell lines as well as the use of large sequencing, CRISPR, and drug vulnerability data sets.
Postdoctoral positions are available in the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study hematopoietic stem cell biology and development. Our laboratory has two major areas of focus: characterizing novel molecular regulators of hematopoietic stem cell transplantation and discovering novel mechanisms that regulate the emergence of the blood system during embryogenesis.
MULTIPLE POSTDOCTORAL RESEARCH ASSOCIATE positions are immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology for highly motivated and creative candidates. Positions are available in the following focus areas:
- Developing genetic prediction models for identifying patients at the highest risk for treatment-related complications. This project is a collaboration between Dr. Zhang and Dr. Yutaka Yasui in the department of Epidemiology & Cancer Control. The postdoc will develop innovative analytical approaches for studying the haplotype structure of pediatric cancer survivors using genomic sequencing data generated from long-read technology. This postdoc position will be jointly supervised by Drs. Zhang and Yasui and mentored by Dr. Zhang and senior-level scientists in her lab in areas of cancer genomics, clonal evolution, visualization, mathematics, and software engineering. Current analytical approaches involve integrating data generated from patient samples and experimental models by whole-genome sequencing, RNA-seq, ChIP-seq, 3D genome, and single cell profiling. The successful candidate will have a strong interest in quantitative data analysis with formal training in one of the following areas: genomics, bioinformatics, computer science, genetics, or cancer biology. Computer programming skills are preferred and interest or experience in genome assembly is a plus.
Successful candidates are expected to excel at critical thinking, be quick learners for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidates must have a doctoral degree (PhD or MD), an excellent publication record, and great communication skills. The lab will provide working experience for a fellow who is interested in leading or participating in all aspects of cancer omics studies via multi-disciplinary teamwork with mentoring from our senior-level scientists. Each fellow will have opportunities to interact with leaders in the fields of pediatric cancer and translational research within and outside the institution. Innovative research leading to high-impact scientific publication is highly encouraged and will be supported by the lab’s research infrastructure. For those with ambitious career goals, inter-disciplinary training will be provided to broaden or strengthen computational or biological expertise. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.
Interested applicants are encouraged to complete the online application. When applying, please include areas of specific interest in cover letter.
Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics, and computer science.
St. Jude provides a highly interactive and supportive environment for researchers’ career development.
Jinghui Zhang, PhD
Chair, Department of Computational Biology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
Two postdoctoral positions are available to study mechanisms of Sonic Hedgehog signal transduction in Stacey Ogden’s lab at St. Jude Children’s Research Hospital, Memphis, TN. The successful candidates will join a collaborative work group aimed at understanding how the Sonic Hedgehog pathway is regulated during development, and dissecting how its regulation is usurped in cancer. Areas of interest include biogenesis and secretion of the Hedgehog ligand, contributions of lipid metabolism to pathway activity, regulation and signaling of the signal transducer Smoothened and investigation of the downstream effectors to which it signals. Research projects in the lab will entail use of biochemical and cell biological techniques and mouse model systems.
This molecular neuroscience position requires an individual with expertise in molecular neuroscience and the analysis of genome stability in the nervous system. A detailed working knowledge of neural development, mouse genetics and cutting-edge molecular biology is essential. This position will focus on understanding the role for various genome stability factors in preventing diseases of the nervous system including neurodevelopmental and neurodegenerative disorders and brain tumors.
One postdoctoral position is available for motivated candidates in the laboratory of Dr. Junmin Peng at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. The successful applicant will use systems biology and mathematical modeling methods to interpret temporal multi-omics datasets and to explore molecular mechanisms of common human disorders (e.g. Alzheimer’s disease and cancer). Integrated systems biology analyses of comprehensive omics data offer a systems or holistic view, for unbiased identification of central disease gene/protein networks, functional modules and master regulators. Beyond big data analysis, molecular targets of interest will be followed in subsequent hypothesis-driven studies in cellular and animal models. We will also investigate the perturbation of cellular systems by small molecule drugs that modulate the activities of these targets. The overarching aim is to develop systems biology approaches and provide novel insights into the pathogenesis and therapeutic intervention, as well as disease biomarker discovery for precision medicine (https://www.stjude.org/peng). Our publication record is available on Google Scholar (150+ publications, 17,500+ citations, http://scholar.google.com/citations?user=vFzS-awAAAAJ&hl=en, e.g. Tan et al. Immunity 2017, Lee et al. Cell 2017, Bai et al. PNAS 2013, and Xu et al. Cell 2009). Postdoctoral fellows in our group have extensive interaction with other 20+ members for career development in mass spectrometry-based proteomics and metabolomics, systems biology and independent research of human disease. Approximately 50% of postdoctoral alumni (n = 19) become principal investigators or medical doctors.
St. Jude is a top-ranked hospital (No. 1 Pediatric Cancer Hospital in 2017) and a world-class basic research institute with 220+ faculty members, including renowned faculty (e.g., Nobel Laureate, National Academy of Sciences, Institute of Medicine, and HHMI). St. Jude offers extraordinary resources and facility, a highly interactive environment for career development, and has been on FORTUNE magazine’s “100 Best Companies to Work For” list. St. Jude postdoctoral fellows are provided with a competitive salary, a professional development allowance, and an array of benefits, including health, dental and vision coverage, and a retirement program.
PLEASE COMPLETE THIS APPLICATION ONLY WHEN YOU HAVE BEEN REQUESTED TO DO SO BY A ST. JUDE POSTDOCTORAL RECRUITER.
The Tsai, Weiss, and Miller Laboratories are seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship to develop potentially curative strategies to treat sickle cell disease by CRISPR-Cas gene editing of human hematopoietic stem cells.
You will have the opportunity to lead new projects such as:
- Optimizing pre-clinical CRISPR-Cas gene editing strategies for induction of fetal hemoglobin in red blood cell progeny of edited human hematopoietic stem and progenitor cells
- Developing improved genomic methods to define and measure genome-wide activity of gene editing nucleases
- Protein engineering of CRISPR-Cas nucleases for precise gene correction
In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.
This postdoc position in the Department of Pharmaceutical Sciences is seeking a dedicated and motivated cancer researcher with a Ph.D. degree in the field of life science to investigate biological mechanisms driving metastasis of pediatric hepatoblastoma (HB) and hepatocellular carcinoma (HCC).
The metastatic forms of liver cancer are incurable and the efforts to develop more effective treatment have been hampered by the lack of relevant model systems that allow detailed biological understanding of the metastasis progress. Our lab recently established highly metastatic mouse models of both HB and HCC via an innovative 3D liver cancer spheroid-based approach. There are two projects we are looking for a motivated postdoc to take on: (1) we have identified a group of genes commonly dysregulated in the metastatic HB and HCC compared to their non-metastatic counterparts. We are interested in investigating their roles in regulating metastasis via both gene-orientated and CRISPR-based screening approaches; (2) we have observed significant tumor cell dissemination at both early and late stage of tumor development in the HB and HCC models. We are taking a single-cell RNA-seq approach to systematically characterize the molecular and cellular cascades of liver cancer metastasis by gene expression profiling of disseminated tumor cells at different metastasis stages and different anatomic locations.
The Obeng Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the pathogenesis of myeloid malignancies. The major interests of the lab are determining how mutations in components of the mRNA spliceosome and epigenetic regulators cooperate to cause clonal hematopoiesis and leukemia, in addition to identifying and studying novel treatments that selectively target malignant clones.
You will have the opportunity to develop and lead projects using several cutting-edge model systems including:
- Isogenic immortalized cell lines generated using CRISPR-Cas gene editing
- Novel xenograft and transgenic in vivo systems
- Primary patient samples
In this position, you will gain extensive experience and training in genomics, stem cell biology, and pre-clinical study development.
St. Jude Children’s Research Hospital is a top-ranked Pediatric Cancer Hospital and a world-renowned basic research institute with over 200 faculty members. St. Jude offers a highly collaborative research and training environment that includes state-of-the-art facilities and resources. Postdoctoral research fellows are provided with a competitive salary, excellent benefits, and a professional development allowance.
A postdoctoral research position is available in the laboratory of Dr. Terrence Geiger in the Department of Pathology at St. Jude Children’s Research Hospital studying the biology and application of chimeric antigen receptor (CAR) T cells for cancer immunotherapy. We are particularly interested in understanding the molecular, cellular, and immunologic mechanisms influencing CAR T cell function and activity against tumor targets in immune competent hosts. Our aim is to develop improved adoptive immunotherapies for hematologic malignancies. The successful applicant will utilize advanced genetic engineering methodologies and novel genetically-modified mice and primary immune cells to examine CAR T cell mechanisms, and should have strong experience in immunology and cell or molecular biology.
St. Jude Children’s Research Hospital offers outstanding support for post-doctoral researchers, as well state-of-the-art facilities and career development opportunities.
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.
A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system. We are particularly interested in dissecting the signaling pathways involved in innate immunity and cell death (NLRs, inflammasomes). Please see the following articles:
Nature (2016) doi:10.1038/nature20597
Cell (2016) 167(2):382-96.
Nature Rev Immunology (2016) 16(1):7-21
Cell (2015) 162(1):45-58.
Nature Immunology (2015) 16(5):467-75.
Nature (2014) 516(7530):246-9
Nature (2013) 498(7453):224-7.
Nature Immunology (2013) 14(5):480-8.
Nature (2012) 488(7411):389-93.
Cancer Cell (2011) 20(5):649-60.
Nature Immunology (2011) 12(10):1010-6.
Immunity (2011) 34(1):75-84.
The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows in innate immune system including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases and cancer biology. Generous salary support and benefits package that include professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
A postdoctoral training position is available to study lipid metabolism in bacteria. Projects encompass bacterial physiology, regulation of gene expression, chemical and structural biology. Laboratory expertise in one or more of these areas and a career interest in studying membrane lipid metabolism, biochemistry or bacterial pathogenesis are desirable.