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A post-doctoral fellowship position is available in the laboratory of Dr. Jeffery Klco in the Department of Pathology at St Jude Children’s Research Hospital to study the development of myeloid tumors in children. In particular, we are interested in the mutations that result in pediatric acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The experimental models include genetically-modified mice and primary hematopoietic cells, both derived from these mice and from humans, as well as in vitro systems to explore signaling, cell death, and transcriptional regulation. Moreover, we complement these strategies with xenotransplantation approaches and genomic technologies, including RNA-seq, whole exome sequencing and various targeted sequencing modalities. The goal of these studies is to ultimately improve the outcome of children with AML and MDS through a better understanding of the disease pathogenesis.
The Department of Radiation Oncology at St. Jude Children’s Research Hospital is seeking a candidate for a two-year postdoctoral research position. This is an outstanding opportunity to join a renowned team at the U.S. News and World Report’s No. 1 ranked pediatric cancer hospital. As a part of the Department the postdoctoral fellow would have access to world-class resources, including the world’s first proton therapy center with pencil beam scanning technology designated solely for the treatment of pediatric cancer, the first in the world installation of detector-based spectral CT in a Radiation Oncology Department, state-of-the-art 1.5T and 3T MR scanners, and a recently installed digital PET/CT.
The main research topics this candidate would be directly involved with include:
- investigating relationships between linear energy transfer (LET) and toxicity events in pediatric patients
- establishing planning strategies that minimize the impact of LET on plan quality
- conducting focused research related to biological optimization of proton radiotherapy treatment plans
Postdoctoral Fellowships are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital, to investigate cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. We are particularly interested in understanding the signaling network and metabolic programs mediated by mTOR and related pathways in basic T cell and dendritic cell biology. We also investigate mechanisms of tumor immunity and immunotherapy. The experimental models include genetically-modified mice and primary immune cells derived from these mice, as well as in vitro systems to explore signaling, metabolic, transcriptional and epigenetic regulation. Moreover, we use interdisciplinary strategies by integrating these immunological approaches with cutting-edge systems biology tools including transcriptomics, proteomics, metabolomics and network reconstruction. Please see the following articles (Nature 499:485 (2013); Immunity 39:1043 (2013); Nature Immunology 16:178 (2015); Nature Immunology 17:277 (2016); Immunity 45:540 (2016); Nature 548:602 (2017); Immunity 46:488 (2017); J Exp Med 214:2629 (2017)) for additional information.
St. Jude Children’s Research Hospital, a private research institute, located in Memphis, Tennessee, USA, was recently named the nation's No. 1 pediatric cancer hospital. St. Jude offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salary and excellent benefits, to postdoctoral fellows.
Several postdoctoral researcher positions are immediately available in the laboratory of Dr. Doug Green in the Department of Immunology in St. Jude Children’s Research Hospital. Research in Dr. Green’s laboratory focuses on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the fundamental molecular events directing the death and survival of the cell. Preference will be given to individuals with an interest in cell death mechanisms, or the metabolism of activated T lymphocytes.
The Yang Laboratory is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the epigenetic alterations of solid tumors and leukemia. The major interests of the lab are to study how alterations of histone demethylases causes cancer progression and therapy resistance, and to develop novel treatments to target histone demethylases.
Primary Duties and Responsibilities:
- Generate isogenic immortalized cell lines using CRISPR/Cas9 gene editing
- RNA-seq, ChIP-seq, ATAC-seq, Hi-C
- Generate leukemia or solid tumor models using conditional knockout and transgenic systems
- Establish Ex Vivo disease models and engraft patient-derived xenografts
- Test the therapeutic efficacy of novel inhibitors using in vivo and in vitro cancer models
- Writing first author manuscript
The Department of Radiation Oncology at St. Jude Children’s Research Hospital is seeking a post-doctoral associate to provide support for physics research focused on proton range-based registration and proton range verification through phantom and patient studies and data acquisition, analysis and model improvement. Publishing research papers is an expectation. The duration of the postdoctoral research associate assignment is two years, effective July, 2018.
The aim of proton range-based registration is to mitigate proton range uncertainty caused by daily patient positioning and body anatomic changes. The goal of proton range verification is to improve the verification accuracy in clinical scenarios with and without range-based registration.
St. Jude offers a highly collaborative research environment as well as exceptional support for scientific discovery. The candidate will work closely with the supervisor/mentor, group members, clinical therapy and physics staff, radiation oncologists, lT support staff and other staff. Opportunities to gain clinical experience with available systems will be provided.
Resources and Equipment
The St. Jude Red Frog Events Proton Therapy Center is the first proton therapy center in the world dedicated solely to the treatment of children with cancer. The proton center has a synchrotron-based proton pencil beam scanning system. The system includes two gantry rooms and one fixed beam room; the latter is equipped with a mini pencil beam scanning system. The center has the most accurate patient positioning systems including camera-assisted robotic positioning and gantry-independent robotic kV CBCT.
The department has a wide range of state of the art imaging systems for treatment planning and adaptive therapy that will be used for proton range verification. These systems include two MRI units (1.5T and 3T) and a multi-layer detector spectral CT. A digital PET/CT will be used for proton range verification. The department houses two photon linear accelerators with MV-CBCT systems. A high-dose-rate brachytherapy afterloader is equipped with a digital fluoroscopy unit. A full range of state of the art radiation measurement equipment and specialized phantoms are available. The department uses a variety of treatment planning systems supporting the research.
A postdoctoral position is available in the lab of Dr. Jay Bikoff, beginning in spring/summer 2018.
The ideal candidate is a highly motivated individual interested in understanding the functional organization of neural circuits that control movement. Current projects focus on cell-type diversity within the spinal cord, and how descending systems in the brain convey information to different types of interneurons in the spinal motor system. We are also interested in exploring the functional roles of spinal inhibitory interneurons in motor output.
Because these projects take advantage of a highly multidisciplinary approach, including mouse and viral genetic tools, single-cell genomics, whole-brain imaging with light-sheet microscopy, and mouse behavior, we are excited to recruit scientists with many different backgrounds, talents, and interests. Preference will be given to applicants who have received their PhD in the past 1-3 years. It is expected that the candidate will develop their own research project, interact collaboratively with other members of the lab, and have excellent oral and written communication skills. The Bikoff lab has a strong commitment to mentoring and training lab members at all stages of their scientific career.
Outstanding candidates are invited to apply for postdoctoral fellowships in the Pediatric Cancer Survivorship Research Training Program at St. Jude Children’s Research Hospital. This program is designed to provide comprehensive interdisciplinary training to develop the next generation of global scientific leaders in the field. As a fellow, you will benefit from access to unique datasets and expertise, a top-ranked scientific environment, and superb mentoring, benefits, and professional development opportunities.
Positions are available with faculty mentors in diverse research areas, including epidemiology; genetics; computational biology; psychology and neuropsychology; neuroscience; exercise physiology, oncology; pharmacology; radiology; surgery; and biostatistics. Fellows also choose secondary mentors and work with clinical collaborators for additional interdisciplinary research. Positions offer individualized training in research design and data collection, data analysis and interpretation, scientific writing, grant preparation and grant review.
St. Jude leads some of the world’s largest survivorship research programs. Data are available from thousands of survivors in two long-term cohort studies, St. Jude Lifetime Cohort Study (SJLIFE) and the Childhood Cancer Survivor Study (CCSS), and fellows also have access to exceptional core facilities to help advance their research.
St. Jude is committed to providing an outstanding environment for mentored career development and offers a rich intellectual environment and resources for research and training. Benefits include:
- Opportunity to obtain a Master of Public Health in epidemiology, biostatistics or health systems policy with full tuition coverage
- Opportunities to participate in St. Jude Global Pediatric Medicine program conducting clinical outcomes research in Central and South America, Mexico, the Eastern Mediterranean, China, and Southeast Asia
- Professional development account and travel support to attend conferences
- Competitive stipend above current NIH levels plus relocation assistance, three weeks paid vacation, tuition reimbursement, paid leave, and medical, dental and vision health coverage
St. Jude Children’s Research Hospital is a private nonprofit academic research institution with a mission to advance cures, and means of prevention, for pediatric catastrophic disease through research and treatment. St. Jude is a NCI-designated Comprehensive Cancer Center and is ranked as the #1 pediatric cancer hospital in the country by U.S. News and World Report. For more information on St. Jude see www.stjude.org.
How to Apply
Applicants must have a PhD or equivalent doctoral degree, MD, DO, or PharmD, with excellent oral and written communication skills. Multiple positions are available, funded through a new T32 NCI training grant or our institutional budget. Due to NIH requirements, applicants to the positions funded by the T32 training grant must be a citizen or a noncitizen national of the United States or have been lawfully admitted for permanent residence at the time of appointment.
To apply, please submit the online application and provide a curriculum vitae, transcripts of your academic records, three letters of reference (from mentors, professors and residency program directors for applicants with clinical training), and a brief summary of prior and anticipated research projects. Trainees will be expected to be highly productive through research publications, presentations at scientific meetings, and submission of at least one grant application.
Application materials and inquiries to:
Kevin Krull, PhD
Department of Epidemiology and Cancer Control
St. Jude Children’s Research Hospital
262 Danny Thomas Place, MS 375
Memphis. TN 38105
The Youngblood laboratory is recruiting a postdoctoral researcher to study T cell responses to chronic infections and cancer. The project will included assessment of T cell differentiation in individuals with hematological malignancies, with opportunities to utilize animal models to investigate molecular mechanisms involved in memory T cell differentiation.
A postdoctoral fellowship is available immediately in the laboratory of Dr. Alessandra d’Azzo in the Department of Genetics. We are seeking a highly motivated postdoctoral scientist to study biological mechanisms involved in neurodegeneration associated with premature aging. The d’Azzo lab uses animal models of pediatric lysosomal storage diseases to dissect mechanisms of pathogenesis downstream of lysosomal enzymes and their substrates that result in loss in neural cell proteostasis, and parallel adult neurodegenerative conditions of protein aggregation, such as Alzheimer’s disease. The candidate must have a strong background in molecular and cell biology, specifically in neurobiology.
A postdoctoral fellowship is available immediately in the laboratory of Dr. Alessandra d’Azzo in the Department of Genetics. We are seeking a highly motivated postdoctoral scientist to study biological mechanisms involved in tumor progression and metastasis with special interest in tumor microenvironment. The d’Azzo lab uses animal models of pediatric lysosomal storage diseases to dissect mechanisms of pathogenesis downstream of lysosomal enzymes that are implicated in aging and other adult diseases such as cancer. The candidate must have a strong background in molecular and cell biology, specifically in cancer biology.
Postdoctoral fellow positions are available in the Kalodimos lab in the Structural Biology department at St Jude Children’s Research Hospital. We are seeking highly motivated researchers to study large and dynamic macromolecular complexes by NMR spectroscopy. Biomolecular systems currently studied in the lab include molecular chaperones, protein kinases, protein secretion and translocation pathways, membrane receptor proteins and several multi-protein complexes. The NMR center at St Jude is outstanding and includes three 600 MHz, two 700 MHz, 800 MHz, and a 850 MHz. The first 1.1 GHz in the world is scheduled to be delivered early next year. Ample opportunities for employing and training in other technologies such as cryo-EM and X-ray crystallography will be available.
A postdoctoral researcher position is immediately available in Dr. Rhea Sumpter, Jr.’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital. Studies in Dr. Sumpter’s laboratory utilize innovative approaches and cutting-edge technologies to decipher the role of Fanconi anemia pathway proteins in selective autophagy, which is an ancient cell biology pathway that removes unwanted cytoplasmic constituents (e.g. intracellular pathogens, damaged organelles, protein aggregates) and delivers them to lysosomes for destruction. Defects in the autophagy pathway have been linked to numerous pathologies, including increased susceptibility to infectious and autoinflammatory diseases, cancer, metabolic disorders, and aging. We are focused on investigating the links between selective autophagy mediated by Fanconi anemia pathway proteins and host defense against viral infection, mitochondrial quality control, regulation of inflammasome signaling, bone marrow failure, and leukemogenesis. These studies will result in the discovery of the novel players and concepts that will deepen our understanding of the role of selective autophagy in health and disease, and may lead to new therapeutic targets for Fanconi anemia patients as well as for patients affected by the many other diseases in which the functioning of the autophagy pathway is impaired.
The Department of Epidemiology and Cancer Control at St. Jude Children's Research Hospital is seeking a postdoctral fellow to work in the intersection of computational and biological sciences, analyzing whole genome sequencing data of over 3000 childhood cancer survivors to predict late adverse outcomes among them. The position is funded by a 5-yr NIH grant (which is in its 1st year currently). The fellow will work in a highly collaborative environment with computational, biological, clinical, and population scientists at St. Jude, utilizing the existing (i.e., ready to be analyzed), high-quality, exceptionally strong data on genome, treatment exposures, and clinically/laboratory ascertained phenotypes to lead his/her projects for high-impact publications. The department and hospital are known for its excellence and the fellow will be mentored by the interdisciplinary faculty.
Postdoctoral positions are available in the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study hematopoietic stem cell biology and development. Our laboratory has two major areas of focus: characterizing novel molecular regulators of hematopoietic stem cell transplantation and discovering novel mechanisms that regulate the emergence of the blood system during embryogenesis.
MULTIPLE POSTDOCTORAL RESEARCH ASSOCIATE positions are immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology for highly motivated and creative candidates. Positions are available in the following focus areas:
- Developing genetic prediction models for identifying patients at the highest risk for treatment-related complications. This project is a collaboration between Dr. Zhang and Dr. Yutaka Yasui in the department of Epidemiology & Cancer Control. The postdoc will develop innovative analytical approaches for studying the haplotype structure of pediatric cancer survivors using genomic sequencing data generated from long-read technology. This postdoc position will be jointly supervised by Drs. Zhang and Yasui and mentored by Dr. Zhang and senior-level scientists in her lab in areas of cancer genomics, clonal evolution, visualization, mathematics, and software engineering. Current analytical approaches involve integrating data generated from patient samples and experimental models by whole-genome sequencing, RNA-seq, ChIP-seq, 3D genome, and single cell profiling. The successful candidate will have a strong interest in quantitative data analysis with formal training in one of the following areas: genomics, bioinformatics, computer science, genetics, or cancer biology. Computer programming skills are preferred and interest or experience in genome assembly is a plus.
Successful candidates are expected to excel at critical thinking, be quick learners for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidates must have a doctoral degree (PhD or MD), an excellent publication record, and great communication skills. The lab will provide working experience for a fellow who is interested in leading or participating in all aspects of cancer omics studies via multi-disciplinary teamwork with mentoring from our senior-level scientists. Each fellow will have opportunities to interact with leaders in the fields of pediatric cancer and translational research within and outside the institution. Innovative research leading to high-impact scientific publication is highly encouraged and will be supported by the lab’s research infrastructure. For those with ambitious career goals, inter-disciplinary training will be provided to broaden or strengthen computational or biological expertise. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.
Interested applicants are encouraged to complete the online application. When applying, please include areas of specific interest in cover letter.
Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics, and computer science.
St. Jude provides a highly interactive and supportive environment for researchers’ career development.
Jinghui Zhang, PhD
Chair, Department of Computational Biology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
This molecular neuroscience position requires an individual with expertise in molecular neuroscience and the analysis of genome stability in the nervous system. A detailed working knowledge of neural development, mouse genetics and cutting-edge molecular biology is essential. This position will focus on understanding the role for various genome stability factors in preventing diseases of the nervous system including neurodevelopmental and neurodegenerative disorders and brain tumors.
One postdoctoral position is available for motivated candidates in the laboratory of Dr. Junmin Peng at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. The successful applicant will use systems biology and mathematical modeling methods to interpret temporal multi-omics datasets and to explore molecular mechanisms of common human disorders (e.g. Alzheimer’s disease and cancer). Integrated systems biology analyses of comprehensive omics data offer a systems or holistic view, for unbiased identification of central disease gene/protein networks, functional modules and master regulators. Beyond big data analysis, molecular targets of interest will be followed in subsequent hypothesis-driven studies in cellular and animal models. We will also investigate the perturbation of cellular systems by small molecule drugs that modulate the activities of these targets. The overarching aim is to develop systems biology approaches and provide novel insights into the pathogenesis and therapeutic intervention, as well as disease biomarker discovery for precision medicine (https://www.stjude.org/peng). Our publication record is available on Google Scholar (150+ publications, 17,500+ citations, http://scholar.google.com/citations?user=vFzS-awAAAAJ&hl=en, e.g. Tan et al. Immunity 2017, Lee et al. Cell 2017, Bai et al. PNAS 2013, and Xu et al. Cell 2009). Postdoctoral fellows in our group have extensive interaction with other 20+ members for career development in mass spectrometry-based proteomics and metabolomics, systems biology and independent research of human disease. Approximately 50% of postdoctoral alumni (n = 19) become principal investigators or medical doctors.
St. Jude is a top-ranked hospital (No. 1 Pediatric Cancer Hospital in 2017) and a world-class basic research institute with 220+ faculty members, including renowned faculty (e.g., Nobel Laureate, National Academy of Sciences, Institute of Medicine, and HHMI). St. Jude offers extraordinary resources and facility, a highly interactive environment for career development, and has been on FORTUNE magazine’s “100 Best Companies to Work For” list. St. Jude postdoctoral fellows are provided with a competitive salary, a professional development allowance, and an array of benefits, including health, dental and vision coverage, and a retirement program.
PLEASE COMPLETE THIS APPLICATION ONLY WHEN YOU HAVE BEEN REQUESTED TO DO SO BY A ST. JUDE POSTDOCTORAL RECRUITER.
The Tsai, Weiss, and Miller Laboratories are seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship to develop potentially curative strategies to treat sickle cell disease by CRISPR-Cas gene editing of human hematopoietic stem cells.
You will have the opportunity to lead new projects such as:
- Optimizing pre-clinical CRISPR-Cas gene editing strategies for induction of fetal hemoglobin in red blood cell progeny of edited human hematopoietic stem and progenitor cells
- Developing improved genomic methods to define and measure genome-wide activity of gene editing nucleases
- Protein engineering of CRISPR-Cas nucleases for precise gene correction
In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.