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A Postdoctoral Research Fellow position is available to study genomics and pharmacogenomics of childhood leukemia. Our laboratory is a part of the National Institutes of Health Pharmacogenomics Research Network (PGRN), a nationwide consortium of research programs focusing on the genetic basis of inter-patient variability in drug response and clinical implementation of genetics-based treatment individualization. Using state-of-the-art genomic tools (expression and SNP arrays, next-generation sequencing), we are interested in identifying both inherited and tumor genetic variations (e.g. single nucleotide polymorphisms, copy number variations, and gene expression) related to leukemia susceptibility and treatment response (JAMA 2009;30:393; Nat Genet 2011 43:237; Nat Genet 2013 45:290; Nat Genet 2013 45:1494, J Clin Oncol 2015 33:1235; Lancet Oncol 2015 16:1659, Nat Genet 2016 48:367,). Functional and mechanistic studies utilizing preclinical models (cell culture and animal model) and clinical samples are critical components of the highly translational research program in this laboratory.
We are seeking ambitious postdoctoral fellows with a track record of productivity and strong interest in translational cancer research. Applicants should have a recent doctoral degree (PhD, MD, or combined degrees). With a general background in leukemia biology and genomics, the ideal candidate would be familiar with leukemia modeling in vitro/in vivo and molecular pharmacology studies of anti-leukemic drugs.
St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.
Applications, including curriculum vitae, a brief research statement, and the names and contact information of 3 references, should be sent to (preferably via email)
Jun J. Yang, PhD
Dept. of Pharma. Sci.
Hematological Malignancies Program
St. Jude Children’s Research Hospital
262 Danny Thomas Place, Memphis, TN 38105, USA
A postdoctoral position is available in the laboratory of Dr. Lindsay Schwarz in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. The ideal candidate is interested in understanding how neuromodulatory circuits in the brain contribute to diverse behaviors and neurological disorders. Current projects in the lab focus on identifying the role of heterogeneously expressed molecules within the brain structure the Locus Coeruleus (LC), as well as how activation of the LC differentially modulates the brain depending on the situation. We are also interested in understanding how arousal and respiratory neural circuits interact to modulate cognitive and stress-related behaviors. These projects utilize multidisciplinary approaches, including next-generation sequencing, in vivo calcium imaging, viral genetic tools, optogenetics, and behavioral assays. Preference will be given to applicants who have received their PhD in the past 1-3 years and have experience with the techniques listed above. It is expected that the candidate will develop their own research project, interact collaboratively with other members of the lab, and have excellent oral and written communication skills.
St. Jude Children’s Research Hospital offers outstanding support for post-doctoral researchers, as well state-of-the-art facilities and many career development opportunities.
Multiple Postdoctoral Research Associate positions are immediately available in the laboratory of Dr. Jinghui Zhang, chair of the Department of Computational Biology. We are seeking highly motivated and creative candidates to lead the discovery and/or methods development in the following areas: a) non-coding driver variants that affect gene regulation in the context of predisposition, initiation, and progression of pediatric cancer; b) clonal evolution of relapsed cancer; and c) genomic cloud, clinical data integration and visualization. The candidates will have access to the large collection of genomic and epigenetic data generated from pediatric cancer patients, 3D genome technology such as Hi-C/Capture C, long-read sequencing platform, and state-of-art visualization tools. The successful candidate will have a strong interest in quantitative data analysis or data visualization with formal training in one of the following areas: genomics, bioinformatics, computer science, genetics, or cancer biology. Computer programming skills are preferred and interest or experience in genome analysis is a plus.
Successful candidates are expected to excel at critical thinking, be quick learners for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidates must have a doctoral degree (PhD or MD), an excellent publication record, interest in computational analysis, and great communication skills. The lab will provide working experience for a fellow who is interested in leading or participating in all aspects of cancer omics studies via multi-disciplinary teamwork. Each fellow will have opportunities to interact with leaders in the fields of pediatric cancer, epigenetics and translational research within and outside the institution. Inter-disciplinary training will be provided to broaden or strengthen computational or biological expertise.
Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, St. Jude Genomics Cloud, state-of-art high performance computing facility, novel analytical pipelines, latest genomic assay technology, and scientific expertise in genomics, cancer biology, mathematics, and computer science.
St. Jude provides a highly interactive and supportive environment for researchers’ career development.
Jinghui Zhang, PhD
Chair, Department of Computational Biology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understand the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective.
Exciting postdoctoral positions are available immediately in the Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration and polarization.
The Yang Laboratory is seeking two creative and highly motivated candidates, one biologist and one chemist, for fully NIH supported postdoctoral fellowship studying the epigenetic functions in solid tumors and leukemia. The major interests of the lab are to study how alterations of epigenetics causes cancer progression and therapy resistance, and to develop novel inhibitors to target epigenetic modifiers. This is the biologist position. To apply for the chemist position, please click here.
- Understanding of the molecular mechanism by which epigenetic modifiers in cancer progression and therapy resistance by using cutting-edge technologies.
- Mechanism of action of novel epigenetic inhibitors and the therapeutic efficacy of novel inhibitors in vivo and in vitro cancer models
The Yang Laboratory is seeking two creative and highly motivated candidates, one biologist and one chemist, for fully NIH supported postdoctoral fellowship studying the epigenetic functions in solid tumors and leukemia. The major interests of the lab are to study how alterations of epigenetics causes cancer progression and therapy resistance, and to develop novel inhibitors to target epigenetic modifiers. This is the chemist position. To apply for the biologist position, please click here.
- Optimizing lead compounds targeting histone demethylases
- Designing and conducting organic chemistry experiments
- Analysis of biological data to establish quantitative structure-activity relationships
- Application of modern medicinal methods (structure-based ligand design, synthesis of substance libraries, interpretation of physiochemical and ADME data)
The Geeleher Lab is seeking outstanding candidates for fully supported postdoctoral fellowships focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development.
As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs. Learn more at geeleherlab.org.
Current research areas
- Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents
Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics.
The postdoc will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications.
- Developing statistical methods for integrating single cell and bulk tissue expression data to understand the relationship between common inherited genetic variation, gene expression, and drug response
Chemotherapeutic response is a complex trait influenced by numerous factors. Inherited genetic variants influencing gene expression (expression quantitative trait loci, or eQTLs) have been identified as major contributors. However, our recent work has shown that the degree of influence of eQTLs on gene expression in cancer is less well understood than previously thought.
The postdoc will explore how inherited genetic variation influences cancer risk, disease progression and drug response, building on methods developed in the lab to deconvolute eQTL signals from bulk tissue expression data to specific cell types. This work will aim to improve our understanding of inherited genetic variation in cancer and yield computational approaches applicable to a broad variety of complex traits and diseases.
A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) define the existence of this connection in zebrafish, and we are now working to extend these findings to mammalian systems and better understand key details. St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources, and a robust community of talented, engaged, and collaborative investigators. We seek an intelligent, friendly, enthusiastic, committed, and capable individual to join our team.
We are particularly seeking an individual with experience in developmental hematopoiesis using mouse as a model system. In addition to a Ph.D., applicants should have a record of publication, and experience with molecular, biochemical, and cell biological techniques. This position will provide an opportunity for considerable independence and intellectual development, as well as examination of comparative developmental hematopoiesis.
The Clements lab is a friendly group with a keen interest in understanding blood ontogeny and its relationship to malignancy. We support work/life balance and believe that individual happiness is fundamental to scientific discovery and professional fulfillment. Memphis is a vibrant city in the mid-South, with a temperate climate, very active music scene, excellent restaurants, many family-friendly activities, and extremely affordable housing. St Jude Children's Research Hospital offers competitive salary, excellent benefits, and is an equal opportunity employer. Please send a cover letter describing research interests and accomplishments, CV, and the names and addresses of three references to firstname.lastname@example.org.
A Postdoctoral Research Fellow position is available in the laboratory of Dr. Clinton Stewart in the Department of Pharmaceutical Sciences at St. Jude Children’s Research Hospital. Our laboratory utilizes pharmacokinetic (PK) and pharmacodynamic (PD) modeling to address clinically relevant problems encountered in the therapy of children with brain tumors or solid malignancies. This position will give the applicant a comprehensive training experience that provides a foundation for the successful fellow to become an independent, laboratory-based clinical pharmaceutical scientist in either industry or academia.
Specifically, we apply pharmacometric approaches to results derived from preclinical and clinical studies to better understand the unique aspects of drug therapy for children with cancer, especially infants and very young children. Fellows have the opportunity to gain a breadth of experience including: translation of pre-clinical in vitro and in vivo data into clinical trials, modeling preclinical and clinical pharmacokinetic and pharmacodynamic data, and studying genetic determinants of interpatient variability in pharmacokinetics and pharmacodynamics.
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.
A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system. We are particularly interested in dissecting the signaling pathways involved in innate immunity and cell death (NLRs, inflammasomes). Please see the following articles:
Cell (2018) 173, 1–14
Immunity (2017) 46(4) 635-648
Nature (2016) 540, 583-587
Science Immunology (2016) 1(2): aag204-5
Cell (2015) 162(1):45-58.
Nature Immunology (2015) 16(5):467-75.
Nature (2014) 516(7530):246-9
Nature (2013) 498(7453):224-7.
Nature Immunology (2013) 14(5):480-8.
Nature (2012) 488(7411):389-93.
Cancer Cell (2011) 20(5):649-60.
Nature Immunology (2011) 12(10):1010-6.
Immunity (2011) 34(1):75-84.
The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows in innate immune system including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases and cancer biology. Generous salary support and benefits package that include professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital. As a fellow you will join our faculty in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research. A Ph.D. in statistics, biostatistics, or closely related field is required. Appointment is for two years. Reappointment for a third year is possible depending upon performance and mutual interest. Applicants must have a strong computational background and demonstrate excellent written and verbal communication skills. St. Jude consistently ranks among the top places to work in the U.S. according to multiple workplace surveys. Salary and benefits are competitive. Please upload a cover letter and CV with your online application.
Dr. Stanley Pounds
The Department of Radiation Oncology at St. Jude Children’s Research Hospital is seeking a candidate for a two-year postdoctoral research position. This is an outstanding opportunity to join a renowned team at the U.S. News and World Report’s No. 1 ranked pediatric cancer hospital. As a part of the Department the postdoctoral fellow would have access to world-class resources, including the world’s first proton therapy center with pencil beam scanning technology designated solely for the treatment of pediatric cancer, the first in the world installation of detector-based spectral CT in a Radiation Oncology Department, state-of-the-art 1.5T and 3T MR scanners, and a recently installed digital PET/CT.
The main research topics this candidate would be directly involved with include:
- investigating relationships between linear energy transfer (LET) and toxicity events in pediatric patients
- establishing planning strategies that minimize the impact of LET on plan quality
- conducting focused research related to biological optimization of proton radiotherapy treatment plans
A postdoctoral position is currently available in the Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, in the laboratory of Dr. Xinwei Cao. We study the molecular and cellular mechanisms that regulate the development and tumorigenesis of the vertebrate nervous system. We use transgenic and knockout models and employ an integrated set of molecular, cellular, biochemical, and imaging techniques. We seek self-motivated scientists with strong background in developmental biology, cell biology, signal transduction, or gene regulation and experience in biochemical, molecular, mouse genetics, or imaging techniques.
Postdoctoral Fellowships are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital, to investigate cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. We are particularly interested in understanding the signaling network and metabolic programs mediated by mTOR and related pathways in basic T cell and dendritic cell biology. We also investigate mechanisms of tumor immunity and immunotherapy. The experimental models include genetically-modified mice and primary immune cells derived from these mice, as well as in vitro systems to explore signaling, metabolic, transcriptional and epigenetic regulation. Moreover, we use interdisciplinary strategies by integrating these immunological approaches with cutting-edge systems biology tools including transcriptomics, proteomics, metabolomics and network reconstruction. Please see the following articles (Nature 499:485 (2013); Immunity 39:1043 (2013); Nature Immunology 16:178 (2015); Nature Immunology 17:277 (2016); Immunity 45:540 (2016); Nature 548:602 (2017); Immunity 46:488 (2017); J Exp Med 214:2629 (2017)) for additional information.
St. Jude Children’s Research Hospital, a private research institute, located in Memphis, Tennessee, USA, was recently named the nation's No. 1 pediatric cancer hospital. St. Jude offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salary and excellent benefits, to postdoctoral fellows.
Several postdoctoral researcher positions are immediately available in the laboratory of Dr. Doug Green in the Department of Immunology in St. Jude Children’s Research Hospital. Research in Dr. Green’s laboratory focuses on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the fundamental molecular events directing the death and survival of the cell. Preference will be given to individuals with an interest in cell death mechanisms, or the metabolism of activated T lymphocytes.
A postdoctoral researcher position is immediately available in Dr. Rhea Sumpter, Jr.’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital. Studies in Dr. Sumpter’s laboratory utilize innovative approaches and cutting-edge technologies to decipher the role of Fanconi anemia pathway proteins in selective autophagy, which is an ancient cell biology pathway that removes unwanted cytoplasmic constituents (e.g. intracellular pathogens, damaged organelles, protein aggregates) and delivers them to lysosomes for destruction. Defects in the autophagy pathway have been linked to numerous pathologies, including increased susceptibility to infectious and autoinflammatory diseases, cancer, metabolic disorders, and aging. We are focused on investigating the links between selective autophagy mediated by Fanconi anemia pathway proteins and host defense against viral infection, mitochondrial quality control, regulation of inflammasome signaling, bone marrow failure, and leukemogenesis. These studies will result in the discovery of the novel players and concepts that will deepen our understanding of the role of selective autophagy in health and disease, and may lead to new therapeutic targets for Fanconi anemia patients as well as for patients affected by the many other diseases in which the functioning of the autophagy pathway is impaired.
Postdoctoral positions are available in the Department of Hematology at St. Jude Children’s Research Hospital (Memphis, Tennessee, USA) to study hematopoietic stem cell biology and development. Our laboratory has two major areas of focus: characterizing novel molecular regulators of hematopoietic stem cell transplantation and discovering novel mechanisms that regulate the emergence of the blood system during embryogenesis.
This molecular neuroscience position requires an individual with expertise in molecular neuroscience and the analysis of genome stability in the nervous system. A detailed working knowledge of neural development, mouse genetics and cutting-edge molecular biology is essential. This position will focus on understanding the role for various genome stability factors in preventing diseases of the nervous system including neurodevelopmental and neurodegenerative disorders and brain tumors.
One postdoctoral position is available for motivated candidates in the laboratory of Dr. Junmin Peng at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. The successful applicant will use systems biology and mathematical modeling methods to interpret temporal multi-omics datasets and to explore molecular mechanisms of common human disorders (e.g. Alzheimer’s disease and cancer). Integrated systems biology analyses of comprehensive omics data offer a systems or holistic view, for unbiased identification of central disease gene/protein networks, functional modules and master regulators. Beyond big data analysis, molecular targets of interest will be followed in subsequent hypothesis-driven studies in cellular and animal models. We will also investigate the perturbation of cellular systems by small molecule drugs that modulate the activities of these targets. The overarching aim is to develop systems biology approaches and provide novel insights into the pathogenesis and therapeutic intervention, as well as disease biomarker discovery for precision medicine (https://www.stjude.org/peng). Our publication record is available on Google Scholar (150+ publications, 17,500+ citations, http://scholar.google.com/citations?user=vFzS-awAAAAJ&hl=en, e.g. Tan et al. Immunity 2017, Lee et al. Cell 2017, Bai et al. PNAS 2013, and Xu et al. Cell 2009). Postdoctoral fellows in our group have extensive interaction with other 20+ members for career development in mass spectrometry-based proteomics and metabolomics, systems biology and independent research of human disease. Approximately 50% of postdoctoral alumni (n = 19) become principal investigators or medical doctors.
St. Jude is a top-ranked hospital (No. 1 Pediatric Cancer Hospital in 2017) and a world-class basic research institute with 220+ faculty members, including renowned faculty (e.g., Nobel Laureate, National Academy of Sciences, Institute of Medicine, and HHMI). St. Jude offers extraordinary resources and facility, a highly interactive environment for career development, and has been on FORTUNE magazine’s “100 Best Companies to Work For” list. St. Jude postdoctoral fellows are provided with a competitive salary, a professional development allowance, and an array of benefits, including health, dental and vision coverage, and a retirement program.
PLEASE COMPLETE THIS APPLICATION ONLY WHEN YOU HAVE BEEN REQUESTED TO DO SO BY A ST. JUDE POSTDOCTORAL RECRUITER.