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A postdoctoral position is available in the laboratory of Dr. Daniel Savic to study pharmacogenomics in childhood acute lymphoblastic leukemia (ALL). The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of ALL in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and disease relapse. To address these critical questions, the Savic laboratory utilizes functional genomics (i.e. ChIP-seq, ATAC-seq, RNA-seq, Hi-C, etc.) and other high-throughput approaches to identify and functionally characterize noncoding regulatory elements (i.e. promoters, enhancers, insulators, etc.). The long-term goal of the Savic laboratory is to gain a better understanding of genomic mechanisms involved in chemotherapeutic drug resistance. A better understanding of drug resistance mechanisms offers a means of improving overall, as well as relapsed, ALL survival, and can further aid in the development of novel therapeutics that bypass or mitigate drug resistance mechanisms, and/or in the optimization of existing treatment regimens.
The candidate should have training in functional genomics and computational biology, as well as an excellent understanding of next-generation sequencing technology. Experience with R and a programming language (Perl or Python) is required. A strong background in statistical genetics and/or Bayesian statistics is also highly desirable.
Daniel Savic, PhD
Department of Pharmaceutical Sciences
St. Jude Children's Research Hospital
262 Danny Thomas Place, Room I-5103A
Memphis, TN 38105
ph 901 595 5346 fax 901 595 8869
A postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly interactive team studying the chromatin landscape of the childhood brain tumor medulloblastoma. As part of a Collaborative Research Project focused on Chromatin Regulation in Pediatric Cancer, the Northcott Lab is working with leaders in the fields of chromatin biology and pediatric cancer to understand how mutations in the chromatin machinery impact the epigenome to promote medulloblastoma development. We are using a combination of cutting-edge next-generation sequencing approaches (i.e. single-cell RNA-Seq, ATAC-seq, ChIP-seq) on large series of patient tumor samples and in vivo functional assays (i.e. CRISPR/Cas9 genome editing) in primary cells to better understand the role of chromatin deregulation in childhood cancer, especially medulloblastoma, the most common malignant pediatric brain tumor.
Experience in chromatin biology, developmental biology, or cancer biology, along with skills in biochemistry, molecular and cellular biology, genomics/epigenomics, and the use of primary cell cultures and/or in vivo model systems are highly desirable. Individuals having experience with transcriptional regulation and chromatin biology studies will be deemed highly competitive, as will those candidates with some degree of computational experience, although the latter is not a requirement.
BCL-2 family members are well recognized regulators of programmed cell death and are responsible
for regulating the homeostasis of tissues and defects in this pathway contribute to a variety of human
diseases. Myeloid cell leukemia sequence 1 (MCL-1) is a unique anti-apoptotic molecule as its
expression is highly regulated and it plays critical roles in promoting the survival of a myriad of cellular
lineages. Recently, the Opferman laboratory revealed that in addition to its canonical role in
antagonizing cell death that MCL-1 also promotes normal mitochondrial function in cells. These
findings provide an attractive model for how both of MCL-1’s diverse functions may contribute to normal
cell homeostasis and function. Additionally, MCL-1 is a highly amplified gene in human cancer leading
to the possibility that both of these functional aspects may contribute to malignant cell growth and
evasion of apoptosis. Therefore, the Opferman laboratory is taking a multidisciplinary approach to
dissect mechanistically how these functions of MCL-1 are regulated and to understand how these
functional roles of MCL-1 contribute to normal development and oncogenesis.
This post-doctoral position is an ideal opportunity for enthusiastic candidates that have recently
earned/expect to earn a PhD and/or MD, have experience in cell biology, molecular biology, and
biochemical techniques. The strongest candidates will have demonstrated success in conducting
original research as evidenced by peer-reviewed publications.
The Rosch Laboratory is seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship focused on pneumococcal genetics and host-pathogen interactions.
The Roussel Laboratory is seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship to develop potentially curative strategies to treat the most aggressive forms of medulloblastoma for current protocols are inadequate.
You will have the opportunity to lead new projects such as:
- Developing novel genetically engineered murine models that recapitulate the human disease
- Perform high throughput screens of FDA-approved drugs and drugs currently in clinical trials using our current mouse and human models
- Perform CRISPR-Cas9 screens of shRNA libraries to identify novel drivers of medulloblastoma development
- Validate drugs and novel drivers using our established pre-clinical pipeline
In this position, you will gain extensive experience and training in mouse genetics, gene editing, high-throughput screens and pre-clinical trials.
Dr. Zhaoming Wang, a joint faculty member between St. Jude Department of Epidemiology and Cancer Control and the Department of Computational Biology, is seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship to conduct high impact clinical research primarily in genetic epidemiology of cancers (childhood and secondary adulthood cancer), biomarker discovery for late effects of survivors of childhood cancer, and omics-based precision preventive medicine.
You will have the opportunity to work with large scale whole-genome sequencing, whole-exome sequencing, and epigenetic profiling data for a well-established cohort of childhood cancer survivors with clinically assessed rich set of phenotypes including secondary cancers.
In this position, you will gain extensive experience and training in genetic epidemiology, as well as programming skills and analytic expertise in computational biology. You will be provided with opportunities to work within a multi-disciplinary environment and interact with leaders in the fields of pediatric cancer, genetics, epigenetics, and survivorship research.
Two postdoctoral positions are immediately available for motivated candidates at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. Our group has contributed to the discovery of ubiquitin code and RNA splicing dysfunction in Alzheimer’s disease (AD). The successful applicant will develop mass spectrometry-based proteomics, metabolomics and systems biology tools and/or explore AD pathogenesis by the systems biology tools, as well as diverse molecular, cellular and genetic approaches, using clinical human AD specimens, mouse models, and human stem cell-derived organoids. The overarching aim is to study complex molecular interactions by systems biology, and provide novel insights into AD pathogenesis, therapeutic intervention, and disease biomarker discovery for precision medicine (https://www.stjude.org/peng). Our postdoctoral fellows have extensive interaction with other members for career development in cutting-edge technologies and biomedical research, with numerous postdoctoral alumni becoming principal investigators. Our publication record is available on Google Scholar (150+ publications, 19,000+ citations). St. Jude is a top ranked hospital (#1 for pediatric cancer specialty in U.S. in 2017) and a world-class basic research institute with 260+ faculty members. St. Jude postdoctoral fellows are provided with a highly competitive salary (median $54,000) in an affordable city, a professional development allowance ($2,500), and an array of benefits, including sign-on bonus ($3,000), health, dental and vision coverage, and a retirement program.
The Laboratory of Dr. Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a fully supported postdoctoral fellowship in one of two areas: 1) to develop potentially curative CRISPR-Cas gene editing strategies in human hematopoietic stem cells for treatment of sickle cell disease and 2) to define safety of cancer immunotherapy genome editing targets in human T-cells.
You will have the opportunity to lead new projects such as:
- Optimizing pre-clinical CRISPR-Cas gene editing strategies for induction of fetal hemoglobin in red blood cell progeny of edited human hematopoietic stem and progenitor cells
- Protein engineering of CRISPR-Cas nucleases for precise gene correction
- Improving genomic methods to define and measure genome-wide activity of gene editing nucleases
- Developing new strategies to understand the functional biological consequences of genome editing
In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.
PLEASE COMPLETE THIS APPLICATION ONLY WHEN YOU HAVE BEEN REQUESTED TO DO SO BY A ST. JUDE POSTDOCTORAL RECRUITER.
Two postdoctoral positions to study the molecular and cellular mechanism of brain development and cancer are available at the St. Jude Children’s Research Hospital in Memphis, TN, USA. The neocortex, the seat of complex behavior, cognition, and intellect, is tremendously expanded and folded in certain mammals including humans. However, little is known about the mechanisms underlying this neocortical expansion and folding (gyrencephaly). We have shown that Hedgehog signaling promotes gyrencephaly and generated the first transgenic murine model for gyrencephaly, where the small and smooth murine neocortex becomes large and folded one with anatomical and developmental hallmarks of gyrencephalic brains (Wang et al., Nature Neuroscience, 2016). We also use human cerebral organoids and a naturally gyrencephalic model organism, to extend our findings in murine models to naturally gyrencephalic species. Using these models we identified several genes that may play key roles in expansion and folding of the neocortex. We seek candidates who will (1) study the function of these identified genes in neocortical expansion and folding or (2) investigate the development and function of expanded and folded cortical area in a mutant murine model at the cellular, anatomical, physiological, and behavioral levels.
Another research focus is the function of primary cilia and Hedgehog signaling in cancer. Primary cilia play critical roles in multiple signaling pathways and cell cycle progression. We have shown that primary cilia can either promote or prevent cancer depending on the initiating oncogenic mutation (Han et al., Nature Medicine 2009). Recently, we showed that Hedgehog signaling controls protein translation through an mTORC1/4EBP1-dependent pathway and mTORC1 can be targeted to treat medulloblastoma, the most common pediatric brain cancer (Wu et al., Dev Cell in press, http://dx.doi.org/10.1016/j.devcel.2017.10.011). Currently, we are investigating the molecular and cellular mechanism of ciliary function in medulloblastoma and the function of translational targets of Hedgehog signaling in medulloblastoma.
We seek highly motivated individuals who have a strong background and interest in development, stem cell, neuroscience, or cancer. We are particularly interested in experts in in utero gene delivery and live-cell imaging. Applicants should send a summary of previous research, curriculum vitae, and contact information for three references to: firstname.lastname@example.org
A postdoctoral position is available in the laboratory of Dr. Mario Halic. The selected candidate will work in a dynamic environment as they study large and dynamic macromolecular complexes by cryo-EM microscopy. The selected candidate will also study biomolecular systems, which include histone modifying and chromatin remodeling complexes. The new cryo-EM center at St Jude is outstanding and includes Titan Krios and Talos Artica microscopes.
A postdoctoral position is available in the laboratory of Dr. Lindsay Schwarz in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. The ideal candidate is interested in understanding how neuromodulatory circuits in the brain contribute to diverse behaviors and neurological disorders. Current projects in the lab focus on identifying the role of heterogeneously expressed molecules within the brain structure the Locus Coeruleus (LC), as well as how activation of the LC differentially modulates the brain depending on the situation. We are also interested in understanding how arousal and respiratory neural circuits interact to modulate cognitive and stress-related behaviors. These projects utilize multidisciplinary approaches, including next-generation sequencing, in vivo calcium imaging, viral genetic tools, optogenetics, and behavioral assays. Preference will be given to applicants who have received their PhD in the past 1-3 years and have experience with the techniques listed above. It is expected that the candidate will develop their own research project, interact collaboratively with other members of the lab, and have excellent oral and written communication skills.
St. Jude Children’s Research Hospital offers outstanding support for post-doctoral researchers, as well state-of-the-art facilities and many career development opportunities.
Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understand the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective.
Exciting postdoctoral positions are available immediately in the Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration and polarization.
The Geeleher Lab is seeking outstanding candidates for fully supported postdoctoral fellowships focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development.
As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs. Learn more at geeleherlab.org.
Current research areas
- Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents
Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics.
The postdoc will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications.
- Developing statistical methods for integrating single cell and bulk tissue expression data to understand the relationship between common inherited genetic variation, gene expression, and drug response
Chemotherapeutic response is a complex trait influenced by numerous factors. Inherited genetic variants influencing gene expression (expression quantitative trait loci, or eQTLs) have been identified as major contributors. However, our recent work has shown that the degree of influence of eQTLs on gene expression in cancer is less well understood than previously thought.
The postdoc will explore how inherited genetic variation influences cancer risk, disease progression and drug response, building on methods developed in the lab to deconvolute eQTL signals from bulk tissue expression data to specific cell types. This work will aim to improve our understanding of inherited genetic variation in cancer and yield computational approaches applicable to a broad variety of complex traits and diseases.
A Postdoctoral Research Fellow position is available in the laboratory of Dr. Clinton Stewart in the Department of Pharmaceutical Sciences at St. Jude Children’s Research Hospital. Our laboratory utilizes pharmacokinetic (PK) and pharmacodynamic (PD) modeling to address clinically relevant problems encountered in the therapy of children with brain tumors or solid malignancies. This position will give the applicant a comprehensive training experience that provides a foundation for the successful fellow to become an independent, laboratory-based clinical pharmaceutical scientist in either industry or academia.
Specifically, we apply pharmacometric approaches to results derived from preclinical and clinical studies to better understand the unique aspects of drug therapy for children with cancer, especially infants and very young children. Fellows have the opportunity to gain a breadth of experience including: translation of pre-clinical in vitro and in vivo data into clinical trials, modeling preclinical and clinical pharmacokinetic and pharmacodynamic data, and studying genetic determinants of interpatient variability in pharmacokinetics and pharmacodynamics.
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.
A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system. We are particularly interested in dissecting the signaling pathways involved in innate immunity and cell death (NLRs, inflammasomes). Please see the following articles:
Cell (2018) 173, 1–14
Immunity (2017) 46(4) 635-648
Nature (2016) 540, 583-587
Science Immunology (2016) 1(2): aag204-5
Cell (2015) 162(1):45-58.
Nature Immunology (2015) 16(5):467-75.
Nature (2014) 516(7530):246-9
Nature (2013) 498(7453):224-7.
Nature Immunology (2013) 14(5):480-8.
Nature (2012) 488(7411):389-93.
Cancer Cell (2011) 20(5):649-60.
Nature Immunology (2011) 12(10):1010-6.
Immunity (2011) 34(1):75-84.
The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows in innate immune system including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases and cancer biology. Generous salary support and benefits package that include professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
Several postdoctoral researcher positions are immediately available in the laboratory of Dr. Doug Green in the Department of Immunology in St. Jude Children’s Research Hospital. Research in Dr. Green’s laboratory focuses on the process of active cell death and cell survival, extending from the role of cell death in cancer regulation and immune responses in the whole organism to the fundamental molecular events directing the death and survival of the cell. Preference will be given to individuals with an interest in cell death mechanisms, or the metabolism of activated T lymphocytes.
A postdoctoral position is currently available in the Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, in the laboratory of Dr. Xinwei Cao. We study the molecular and cellular mechanisms that regulate the development and tumorigenesis of the vertebrate nervous system. We use transgenic and knockout models and employ an integrated set of molecular, cellular, biochemical, and imaging techniques. We seek self-motivated scientists with strong background in developmental biology, cell biology, signal transduction, or gene regulation and experience in biochemical, molecular, mouse genetics, or imaging techniques.
Postdoctoral Fellowships are available in the laboratory of Dr. Hongbo Chi in the Department of Immunology, St. Jude Children’s Research Hospital, to investigate cell metabolism of the immune system (immunometabolism) and its implications in cancer and other diseases. We are particularly interested in understanding the signaling network and metabolic programs mediated by mTOR and related pathways in basic T cell and dendritic cell biology. We also investigate mechanisms of tumor immunity and immunotherapy. The experimental models include genetically-modified mice and primary immune cells derived from these mice, as well as in vitro systems to explore signaling, metabolic, transcriptional and epigenetic regulation. Moreover, we use interdisciplinary strategies by integrating these immunological approaches with cutting-edge systems biology tools including transcriptomics, proteomics, metabolomics and network reconstruction. Please see the following articles (Nature 499:485 (2013); Immunity 39:1043 (2013); Nature Immunology 16:178 (2015); Nature Immunology 17:277 (2016); Immunity 45:540 (2016); Nature 548:602 (2017); Immunity 46:488 (2017); J Exp Med 214:2629 (2017)) for additional information.
St. Jude Children’s Research Hospital, a private research institute, located in Memphis, Tennessee, USA, was recently named the nation's No. 1 pediatric cancer hospital. St. Jude offers an exceptional research and training environment with state-of-the-art facilities, along with competitive salary and excellent benefits, to postdoctoral fellows.
A postdoctoral researcher position is immediately available in Dr. Rhea Sumpter, Jr.’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital. Studies in Dr. Sumpter’s laboratory utilize innovative approaches and cutting-edge technologies to decipher the role of Fanconi anemia pathway proteins in selective autophagy, which is an ancient cell biology pathway that removes unwanted cytoplasmic constituents (e.g. intracellular pathogens, damaged organelles, protein aggregates) and delivers them to lysosomes for destruction. Defects in the autophagy pathway have been linked to numerous pathologies, including increased susceptibility to infectious and autoinflammatory diseases, cancer, metabolic disorders, and aging. We are focused on investigating the links between selective autophagy mediated by Fanconi anemia pathway proteins and host defense against viral infection, mitochondrial quality control, regulation of inflammasome signaling, bone marrow failure, and leukemogenesis. These studies will result in the discovery of the novel players and concepts that will deepen our understanding of the role of selective autophagy in health and disease, and may lead to new therapeutic targets for Fanconi anemia patients as well as for patients affected by the many other diseases in which the functioning of the autophagy pathway is impaired.