Postdoctoral Training Opportunities

Cures don't just happen. St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children.


If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.

Here are our postdoctoral research training opportunities. Please click on the position title for more information, and apply from that page if you are interested.

 

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The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on an interdisciplinary project that will involve in vitro biophysics studies of phase separation and cell biological approaches to assess function. The latter component is in collaboration with Linda Hendershot’s laboratory in the Department of Tumor Cell Biology. The project seeks to delineate the molecular mechanisms by which cancer mutations in the tumor suppressor SPOP, a ubiquitin ligase subunit, result in dysregulation of substrates. An important goal is to assess the role of phase separation for SPOP function.   The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.       Contact Information  Tanja Mittag, PhD  Department of Structural Biology  St. Jude Children’s Research Hospital  262 Danny Thomas Place  Memphis, TN  38105-3678  E-mail: tanja.mittag@stjude.org  https://www.stjude.org/mittag   
ID
43583
Department
Structural Biology
Faculty Member
Tanja Mittag
The Geeleher Lab is seeking outstanding candidates for a postdoctoral fellowship focused on developing innovative computational and statistical approaches to inform and improve therapies for pediatric cancer and other diseases. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. As a postdoctoral fellow, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Postdocs have considerable flexibility and freedom to develop their research programs. Current research areas - Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics. The postdoc will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications. - Developing statistical methods for integrating single cell and bulk tissue expression data to understand the relationship between common inherited genetic variation, gene expression, and drug response Chemotherapeutic response is a complex trait influenced by numerous factors. Inherited genetic variants influencing gene expression (expression quantitative trait loci, or eQTLs) have been identified as major contributors. However, our recent work has shown that the degree of influence of eQTLs on gene expression in cancer is less well understood than previously thought. The postdoc will explore how inherited genetic variation influences cancer risk, disease progression and drug response, building on methods developed in the lab to deconvolute eQTL signals from bulk tissue expression data to specific cell types. This work will aim to improve our understanding of inherited genetic variation in cancer and yield computational approaches applicable to a broad variety of complex traits and diseases.   About the Geeleher Lab   The lab of Dr. Paul Geeleher is in the Department of Computational Biology at St. Jude Children’s Research Hospital. Dr. Geeleher is recognized for developing innovative computational approaches and has led drug repurposing efforts, spearheaded publications in Nature, Genome Research, Genome Biology, Journal of the National Cancer Institute (JNCI) and Bioinformatics in the last five years and is funded by the NIH. Postdoctoral fellows in the lab will benefit from access to the wealth of high-quality genomics data generated at St. Jude, state-of-art high-performance computing facilities, robust analytical pipelines, the latest laboratory technology, outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science.
ID
43564
Department
Computational Biology
Faculty Member
Paul Geeleher
A postdoctoral position is available in the field of pharmacogenomics. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies functional genomic and high-throughput approaches to identify and functionally characterize cis-regulatory elements and their associated noncoding sequence variants. The long-term goal is to gain a better understanding of the genetic underpinnings of chemotherapeutic drug resistance and relapse in pediatric leukemia.
ID
43528
Department
Pharmaceutical Sciences
Faculty Member
Daniel Savic
Postdoctoral Position – Tumor Microenvironment and Metastasis   A fully funded postdoctoral position is available in the laboratory of Dr. Myriam Labelle at St. Jude Children’s Research Hospital in Memphis, TN, USA. The Labelle laboratory studies the role of the microenvironment in cancer progression and metastasis, with major efforts dedicated to elucidating the molecular mechanisms by which blood platelets, granulocytes, and the extracellular matrix (ECM) cooperate to promote metastasis (Cancer Cell, 20(5):576-90, 2011; PNAS, 111(30):E3053-61, 2014). In recent work (EMBO J, 38(16):e101302, 2019), we discovered that WISP1, a factor secreted by tumor cells upon interactions with platelets, promotes metastasis by inducing collagen linearization in tumors.We are now interested in further understanding the molecular basis of platelet-tumor cell and WISP1-ECM interactions and how they can be targeted to prevent cancer metastasis and improve the survival of cancer patients. Current studies are conducted leveraging a wide array of model systems and techniques including novel mouse models of metastasis, patient-derived xenografts, in vitro co-culture systems, and advanced microscopy approaches.   We are looking for a highly motivated and organized individual to join our team. The applicant should have strong communication skills, the ability to work independently and as part of collaborative research efforts, and a strong desire to make a major contribution to the field of cancer metastasis.   St Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists and offers an outstanding research environment, state-of-the-art scientific resources and facilities, and a community of highly collaborative investigators.   Interested applicants should send a CV, a cover letter describing their research interests and accomplishments, and the names and addresses of 3 references to myriam.labelle@stjude.org.     Contact Information Myriam Labelle, Ph.D. Assistant Member, Department of Developmental Neurobiology St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN  38105 myriam.labelle@stjude.org https://www.stjude.org/labelle
ID
43504
Department
Developmental Neurobiology
Faculty Member
Myriam Labelle
We are seeking a highly motivated Postdoc Research Associate to join Dr. Ji Sun’s lab at St. Jude Children's Research Hospital. Successful candidates will lead research projects focusing on structural mechanisms of membrane proteins.  We use cryo-EM, biophysical, electrophysiological and biochemical approaches to study the function of membrane proteins (Sun and MacKinnon, Cell 2017; Sun J et al, Nature 2014).  The lab has fully access to the state-of-the-art cryo-EM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope, both equipped with K3 detectors.
ID
43510
Department
Structural Biology
Faculty Member
Ji Sun
A postdoctoral position is available in the field of pharmacogenomics. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies functional genomic and high-throughput approaches to identify and functionally characterize cis-regulatory elements and their associated noncoding sequence variants in order to define gene regulatory disruptions impacting pediatric leukemia pharmacogenomics. The long-term goal of the Savic laboratory is to gain a better understanding of the genetic underpinnings of chemotherapeutic drug resistance and relapse in pediatric leukemia.
ID
43512
Department
Pharmaceutical Sciences
Faculty Member
Daniel Savic
Advance hope, medical science, statistical science, and your career as a postdoctoral fellow in the Department of Biostatistics at St. Jude Children’s Research Hospital.  As a fellow you will join our faculty in the Department of Biostatistics in providing statistical support and developing innovative statistical methods for research projects at the cutting edge of biomedical research.    For eight consecutive years, St. Jude has ranked among the top places to work in the U.S. by Forbes Magazine.   Salary and benefits are competitive.  Send cover letter, CV, and three recommendation letters to Dr. Tomi Mori via e-mail at tomi.mori@stjude.org. 
ID
43480
Department
Biostatistics
Faculty Member
Motomi Mori
Postdoctoral Fellowships Training Program in Pediatric Cancer Survivorship Research   St. Jude is seeking outstanding candidates for postdoctoral fellowship positions in pediatric cancer survivorship research. As a fellow, you will benefit from access to unique datasets and expertise; a top-ranked scientific environment; and superb benefits, mentoring, and professional development.Positions are available in diverse research areas, including epidemiology, genetics, computational biology, psychology and neuropsychology, neuroscience, exercise physiology, oncology, pharmacology, radiology, surgery and biostatistics. St. Jude leads two of the world’s largest pediatric survivorship research studies, St. Jude LIFE and the Childhood Cancer Survivor Study (CCSS). Other benefits include: - Access to exceptional core facilities to help advance your research - Opportunity to obtain a Master of Public Health in epidemiology or biostatistics with full tuition - Opportunity to participate in St. Jude Global Pediatric Medicine conducting research in CentralAmerica, South America, Mexico, Eastern Mediterranean region, China, and Southeast Asia - St. Jude offers highly competitive stipends and benefits and fosters professional development. To apply or learn more, please contact: Kevin Krull, PhD Department of Epidemiology and Cancer Control St. Jude Children’s Research Hospital kevin.krull@stjude.org   About St. Jude St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for pediatric cancer and childhood disease. It is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and is an Equal Opportunity Employer. For more information, visit www.stjude.org.
ID
43470
Department
Epidemiology & Cancer Control
Faculty Member
Kevin Krull
St. Jude Children’s Research Hospital is seeking a highly motivated Post-Doctoral candidate to join the Department of Structural Biology and the laboratory of Dr. Scott Blanchard to drive interdisciplinary research initiatives in synthetic biology applied to the mechanism of protein synthesis. This work will be funded and carried out in the context of the National Science Foundation Center for Genetically Encoded Materials (http://gem-net.net/). The Blanchard laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advancing the frontiers of biological imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. Research within the Blanchard lab and C-GEM is highly interdisciplinary, collaborative, and team oriented. Candidates must be creative, and exhibit strong leadership skills. They must also be comfortable working within a diverse environment while pursuing highly impactful advances across a range of disciplines. Experience with quantitative biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. This role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.   Responsibilities: - Leadership position in research initiatives aiming to engineer the ribosome-catalyzed protein synthesis mechanism for the purpose of synthetic biology and material science applications. These efforts benefit from collaborative interactions with St. Jude’s Protein Technology Center, Center for Advanced Genome Engineering, as well as Cryo-EM, NMR, X-Ray and Mass-spectrometry centers. - Learn and utilize appropriate assays to answer specific biological questions. - Regularly present research plans and findings in a clear, concise manner to both general and specialized scientific audiences. - Prepare high-quality manuscripts for publication. Assist in training and mentoring of graduate students, other post-docs and visiting scientists where necessary   Publication links: - Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. - Aminoglycoside interactions and impacts on the eukaryotic ribosome. - Miscoding-induced stalling of substrate translocation on the bacterial ribosome. - Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. - MultiperspectivesmFRET reveals rate-determining late intermediates of ribosomal translocation. - Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. - Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. - Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. - Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. - Allosteric control of the ribosome by small-molecule antibiotics. - Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.
ID
43425
Department
Structural Biology
Faculty Member
Scott Blanchard
Changes in the Structure and Organization of the Genome During Neurogenesis   During retinal development, more than 8,000 genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an evolutionarily conserved birth order. Although it has been well established that multiple changes in the epigenome accompany changes in gene expression, little is known about how those processes are coordinated during neurogenesis. Over the past 5 years, we developed a detailed map of the structure and accessibility of the human and mouse retinal genome during development. Specifically, we performed a multifaceted integrated analysis that included profiling of the covalent modifications to the DNA and histones, promoter structure, chromatin accessibility, looping interactions, and euchromatin/heterochromatin localization (https://pecan.stjude.cloud/retinalnucleome). One of the most significant discoveries to come from this comprehensive analysis was the identification of a series of core regulatory circuit super-enhancers (CRC-SEs) adjacent to genes having important roles in retinal development, including Vsx2, Crx, Six3, Otx2, Fgf15, and Ascl1. Each of those CRC-SEs have been deleted in mice using CRISPR-Cas9 and analysis is ongoing. We are also analyzing the evolutionary conservation of those CRC-SEs in human stem cell derived retinal organoids. The results of these studies will be important for filling a fundamental gap in our knowledge about the role of CRC-SEs in retinal development and will set the stage for characterization of CRC-SEs in other genes required for retinogenesis. We are seeking a highly motivated postdoctoral fellow to study the role of CRC-SEs in retinal development and diseases such as macular degeneration and diabetic retinopathy. Training in epigenetics, retinal biology and human stem cell research is preferred.   Michael A. Dyer, Ph.D. Investigator, HHMI Chair and Member, Developmental Neurobiology Department Co-leader Developmental Biology and Solid Tumor Program St. Jude Children’s Research Hospital   @MichaelADyerLab www.stjude.org/dyer  
ID
43435
Department
Developmental Neurobiology
Faculty Member
Michael Dyer
NIH Grant Funded Postdoctoral Associate Positions in Structural Biology    Description: The Moldoveanu laboratory invites applications for a highly motivated Postdoctoral Research Fellow to work on an interdisciplinary project that will involve structural biology, protein engineering, biochemistry, and chemical biology.     Responsibilities: The successful candidate is expected to take a leadership role in ongoing research projects including mechanistic, structure-function studies in programmed cell death. The applicants will receive training in contemporary structural biology, mentoring for developing research proposals, and support with career development.    Qualifications: The successful candidate should have a Ph.D. in structural biology, biochemistry, or related fields. The candidate should demonstrate an academic record of excellent, independent research, and a strong interest in mechanisms of cell death. Applicants with a background in membrane proteins and protein engineering are encouraged to apply.    Environment: The successful candidate will join a highly collaborative laboratory focused on elucidating cell death mechanisms in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in cryo-EM, NMR spectroscopy, X-ray crystallography, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.     Several positions are available. Qualified applicants should apply for job 43407 at:  https://postdoc-stjude.icims.com/jobs/6401/postdoctoral-research-assoc/job   Contact Information  Tudor Moldoveanu, PhD  Department of Structural Biology  St. Jude Children’s Research Hospital  262 Danny Thomas Place  Memphis, TN  38105-3678  E-mail: tudor.moldoveanu@stjude.org  https://www.stjude.org/moldoveanu 
ID
43407
Department
Structural Biology
Faculty Member
Tudor Moldoveanu
A post-doctoral position is available in the laboratory of David Rogers in the field of molecular mycology in the area of antifungal drug resistance. The overarching goal of the Rogers lab is to utilize genome-wide and molecular biological approaches to understand the molecular and genetic basis of antifungal drug resistance in pathogenic opportunistic fungi. The long-term goal of this project is to advance the treatment of invasive candidiasis by identifying the molecular mechanisms underpinning antifungal resistance in the emerging fungal pathogen Candida auris, and to ultimately use this understanding to design therapeutic strategies to overcome them. Our immediate objective is to fully understand the genetic and molecular basis of antifungal resistance in clinical isolates of C. auris.
ID
43301
Department
Pharmaceutical Sciences
Faculty Member
Carla Cook
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.   A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system.  We are particularly interested in dissecting the signaling pathways involved in innate and adaptive immune responses and cell death (NLRs, inflammasomes).  Please see the following articles: Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5. Cell (2015) 162(1):45-58. Nature Immunology (2015) 16(5):467-75. Immunity (2015) 42(4):654-64. Nature (2014) 516(7530):246-9. Nature (2013) 498(7453):224-7.    The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows focused on the innate immune system, including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases, and cancer biology. Generous salary support and a benefits package that includes professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
ID
43259
Department
Immunology
Faculty Member
Thirumala-Devi Kanneganti
St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. We are looking for a candidate to fill any of a number of roles in our highly interdisciplinary, collaborative environment, ranging from single-molecule fluorescence imaging of cells and biomolecules to photophysically-guided development of organic fluorophores. This requires a creative, team-oriented individual with strong leadership skills who is comfortable pursuing highly impactful scientific advances across a range of biological systems and disciplines. Experience with quantitative single-molecule biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. The role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.   Publication links: - Quantifying secondary transport at single-molecule resolution. - Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. - Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. - A partially-open inward-facing intermediate conformation of LeuT is associated with Na<sup>+</sup> release and substrate transport. - Aminoglycoside interactions and impacts on the eukaryotic ribosome. - Dynamics of P-type ATPase transport revealed by single-molecule FRET. - Miscoding-induced stalling of substrate translocation on the bacterial ribosome. - Single-molecule analysis of ligand efficacy in β<sub>2</sub>AR-G-protein activation. - Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging. - Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. - MultiperspectivesmFRET reveals rate-determining late intermediates of ribosomal translocation. - Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. - Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. - Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. - Transport domain unlocking sets the uptake rate of an aspartate transporter. - Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. - Ultra-stable organic fluorophores for single-molecule research. - Allosteric control of the ribosome by small-molecule antibiotics. - Cyanine fluorophore derivatives with enhanced photostability. - Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. - Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.  
ID
43141
Department
Structural Biology
Faculty Member
Roger Altman
A fully funded postdoctoral position is available in the Clements group in the Department of Hematology at St. Jude Children’s Research Hospital to study how the adult hematopoietic system is established during vertebrate embryonic development. We are interested in understanding how early precursors of the sympathetic nervous system and vascular smooth muscle precursors interact with developing endothelial cells to establish the earliest hematopoietic stem cells. Our recent findings (Nature Cell Biology, 19:457-467, 2017) and unpublished data define the existence of this connection in in vertebrates and we are now working to better understand key details. St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources, and a robust community of talented, engaged, and collaborative investigators. We seek an intelligent, friendly, enthusiastic, committed, and capable individual to join our team.   We are particularly seeking an individual with experience in developmental hematopoiesis. In addition to a Ph.D., applicants should have a record of publication, and experience with molecular, biochemical, and cell biological techniques. This position will provide an opportunity for considerable independence and intellectual development, as well as examination of comparative developmental hematopoiesis.   The Clements lab is a friendly group with a keen interest in understanding blood ontogeny and its relationship to malignancy. We support work/life balance and believe that individual happiness is fundamental to scientific discovery and professional fulfillment. Memphis is a vibrant city in the mid-South, with a temperate climate, very active music scene, excellent restaurants, many family-friendly activities, and extremely affordable housing. St Jude Children's Research Hospital offers competitive salary, excellent benefits, and is an equal opportunity employer. Please send a cover letter describing research interests and accomplishments, CV, and the names and addresses of three references to wilson.clements@stjude.org.   https://www.stjude.org/clements https://twitter.com/Zfish_Blood_Lab https://www.linkedin.com/in/wilsonclements/
ID
43118
Department
Hematology
Faculty Member
Wilson Clements
A postdoctoral research associate position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to investigate 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will be developing innovative methods and perform analysis for discovery of cis-regulatory variants and for investigating heterogeneity in 3D genome architecture at the level of single cell. The appointment will be for 2-5 years, depending on the candidate’s goals, qualifications, and productivity.   Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics and computer science.    St. Jude provides a highly interactive and supportive environment for researchers’ career development.   St. Jude Children's Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, sexual orientation, gender identity, transgender status, age, religion, disability, veteran's status or disabled veteran's status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.   Interested candidates, please complete online application and submit CV to ComputationalBiologyRecruitment@stjude.org.
ID
43033
Department
Collaborative Research Program
Faculty Member
Jinghui Baker
A postdoctoral position is available immediately in the laboratories of Dr. Anang Shelat and Dr. Phil Potter within the Department of Chemical Biology and Therapeutics to assess the therapeutic potential of selective transcriptional perturbation in pediatric cancers using small molecules. The identification of the mechanism of action of these compounds, and the molecular determinants which govern susceptibility and resistance, are key motivations for this position. This work will directly support the institution’s translational program, with the goal of identifying clinically relevant chemotherapeutic strategies for pediatric cancer.   The applicant must have a strong background in genomics, epigenetics, biochemistry, and molecular biology. The applicant must be comfortable with developing, validating, and executing biochemical and cell-based assays to quantify transcription and transcriptional complexes. The applicant will be expected to apply high-throughput screening technologies to identify novel small-molecules or drug combination strategies. The applicant is expected to work alongside cancer biologists, computational biologists, pharmacologists, and clinicians in a project team environment, with the end goal of contributing to the discovery of small molecules with the potential to treat pediatric cancers. 
ID
42968
Department
Chemical Biology & Therapeutic
Faculty Member
Anang Shelat
St. Jude Children's Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state of the art facilities and learn from investigators at the forefront of their fields, consider advancing your research training at St. Jude.   A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate cellular signaling in the immune system.  We are particularly interested in dissecting the signaling pathways involved in innate immunity and cell death (NLRs, inflammasomes).  Please see the following articles: Cell (2018) 173, 1–14 Immunity (2017) 46(4) 635-648 Nature (2016) 540, 583-587 Science Immunology (2016) 1(2): aag204-5 Cell (2015) 162(1):45-58. Nature Immunology (2015) 16(5):467-75. Nature (2014) 516(7530):246-9 Nature (2013) 498(7453):224-7. Nature Immunology (2013) 14(5):480-8. Nature (2012) 488(7411):389-93. Cancer Cell (2011) 20(5):649-60. Nature Immunology (2011) 12(10):1010-6. Immunity (2011) 34(1):75-84.   The laboratory of Dr. Thirumala-Devi Kanneganti offers a remarkable training environment for postdoctoral fellows in innate immune system including an opportunity to collaborate with researchers in the departments of Immunology, Infectious Diseases and cancer biology. Generous salary support and benefits package that include professional development funds for journal subscriptions and travel to meetings are available. St. Jude Children's Research Hospital has state-of-the-art facilities including core laboratories for proteomics, microarray analysis of gene expression, transgenic/knock-out technology and animal facilities from biosafety level 2 to enhanced biosafety level 3.
ID
42914
Department
Immunology
Faculty Member
Thirumala-Devi Kanneganti
  Postdoctoral Research Associate-Cell Biology of Neural Development St. Jude Children’s Research Hospital   St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research. Description Neuronal polarity is an essential driving force that coordinates the choreography of neural development. How polarity signaling organizes the behavior of immature neurons, in addition to how polarity signaling cascades are regulated are the key topics studied by the Solecki laboratory. These questions are critical to understanding the pathology of neurodevelopmental diseases, where the production of neurons or their subsequent migration is defective.    Exciting postdoctoral positions are available immediately Solecki lab at St. Jude Children’s Research Hospital for talented and highly motivated individuals interested in understanding the cell biology of neuronal polarity or the regulation of nuclear architecture during neuronal differentiation. The Solecki Lab takes a multidisciplinary approach via cutting edge imaging technologies like lattice light sheet (LLS) microscopy or correlative super-resolution electron microscopy (CLEM) and computational approaches to mechanistically analyze the molecular and cellular mechanisms controlling neuronal differentiation, migration, and polarization.   Contact To apply for this position, submit the online application, and send a C.V. and 3 letters of recommendation to: David J. Solecki, PhD, Department of Structural Biology, Mail Stop 311, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA, david.solecki@stjude.org.
ID
42727
Department
Developmental Neurobiology
Faculty Member
David Solecki
POSTDOCTORAL POSITION to Study Mechanics of the Nuclear Envelope via Data-Driven Computational Modeling.   We are seeking a highly motivated postdoctoral fellow to join the group of Dr. Khaled Khairy. The lab is located in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital in Memphis, TN. We combine continuum mechanics computational models of membrane-bound biological structures with state-of-the-art quantitative image analysis to gain insights into the basis for cell and organelle morphology, and to better understand mechanisms of shape change in normal and pathological cases (www.stjude.org/khairy).   Interested applicants should send their CV, a cover letter describing research experience and interests, and names and addresses of three references to:  khaled.khairy@stjude.org
ID
42653
Department
Developmental Neurobiology
Faculty Member
Khaled Khairy

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