Postdoctoral Research Associate - Structural Biology

Structural Biology
Faculty Member
Scott Blanchard


St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a postdoctoral fellow, to drive interdisciplinary research initiatives in the laboratory of Dr. Scott Blanchard. The laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advanced single-molecule imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. We are looking for a candidate to fill any of a number of roles in our highly interdisciplinary, collaborative environment, ranging from single-molecule fluorescence imaging of cells and biomolecules to photophysically-guided development of organic fluorophores. This requires a creative, team-oriented individual with strong leadership skills who is comfortable pursuing highly impactful scientific advances across a range of biological systems and disciplines.

Experience with quantitative single-molecule biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. The role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.


Publication links:


  • Assume leadership positions in one or more research initiatives to reveal the mechanistic underpinnings of clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, with a special emphasis on mammalian systems. These efforts benefit from collaborative interactions with St. Jude’s Protein Technology Center, Center for Advanced Genome Engineering, as well as Cryo-EM, NMR, X-Ray and Mass-spectrometry centers.
  • Adeptly learn and utilize appropriate assays to answer specific biological questions.
  • Utilize the multiple single-molecule fluorescence instruments within the Single-Molecule Imaging Center including analysis of single-molecule data, model building and statistical analysis.
  • Regularly present research plans and findings in a clear, concise manner to both general and specialized scientific audiences.
  • Regularly prepare high-quality manuscripts for publication.
  • Assist in training and mentoring of graduate students, post-docs and visiting scientists.

Other Information

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

St. Jude is an Equal Opportunity Employer

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