Exploiting Water Network Perturbations in Protein Binding Sites
We are recruiting a postdoc for a computational structural biology project that investigates the role of water network at protein ligand interfaces with a view towards ligand discovery. The position is available immediately and NIH funded for 5 years.
We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein-ligand binding and leverage this information for ligand discovery. As this project integrates experimental and computational data it will require both a solid background in structural biology and significant computational skills for custom data analysis and automation. The project is embedded into a dynamic lab that has strong expertise in modulating protein conformational ensembles with ligands and temperature (see references below).
The project is housed in the Department of Chemical Biology and Therapeutics, and Structural Biology at St. Jude Children’s Research Hospital. It builds on strong investments into a world-class infrastructure in structural and chemical biology. This is an exciting time to join us and build a career while living in an affordable city. This postdoc position is NIH funded for 5 years.
Please direct your questions and application package including a cover letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (firstname.lastname@example.org).
Relevant papers include:
More info at:
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.