Postdoctoral Research Associate - Chemical Biology & Therapeutic

Job Location US-TN-Memphis
Chemical Biology & Therapeutic
Faculty Member
Marcus Fischer


Exploiting Water Network Perturbations in Protein Binding Sites


We are recruiting a postdoc for a computational structural biology project that investigates the role of water network at protein ligand interfaces with a view towards ligand discovery. The position is available immediately and NIH funded for 5 years.


We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein-ligand binding and leverage this information for ligand discovery. As this project integrates experimental and computational data it will require both a solid background in structural biology and significant computational skills for custom data analysis and automation. The project is embedded into a dynamic lab that has strong expertise in modulating protein conformational ensembles with ligands and temperature (see references below).


The project is housed in the Department of Chemical Biology and Therapeutics, and Structural Biology at St. Jude Children’s Research Hospital. It builds on strong investments into a world-class infrastructure in structural and chemical biology. This is an exciting time to join us and build a career while living in an affordable city. This postdoc position is NIH funded for 5 years.


Please direct your questions and application package including a cover letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (


Relevant papers include:

  • Bradford et al. (2021). Temperature artifacts in protein structures bias ligand-binding predictions. Chemical Science. DOI: 10.1039/D1SC02751D
  • Fischer (2021). Macromolecular room temperature crystallography. Q Rev Biophys 54. E1
  • Darby et al. (2019). Water Networks Can Determine the Affinity of Ligand Binding to Proteins. JACS 141, 15818-26.
  • Balius et al. (2017). Testing inhomogeneous solvation theory in structure-based ligand discovery. PNAS E6839-46.
  • Fischer et al. (2015). One crystal, two temperatures: cryocooling penalties alter ligand binding to transient protein sites. Chembiochem 1560-64.
  • Fischer et al. (2014). Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry 6, 575-83.


More info at:

Minimum Education

  • PhD in structural biology or related field

Minimum Experience

  • High proficiency in coding incl Python
  • Interest in dynamic aspects of structural biology including protein flexibility and hydration

Optional requirements:

  • Hands-on molecular biology and crystallography experience

Other Information

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

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