A postdoctoral position is available immediately in the laboratory of Dr. Anang Shelat within the Department of Chemical Biology and Therapeutics to discover and characterize small molecules that induce synthetic lethality in pediatric sarcoma. The identification of the mechanism of action of the compound, and the molecular determinants which govern susceptibility and resistance, are key motivations for this position. This work will directly support the institution’s translational program, with the ultimate goal of identifying clinically relevant chemotherapeutic strategies.
Highly motivated individuals with a recent PhD degree and evidence of scientific accomplishment are encouraged to apply. Good communication skills and willingness to work in a team environment are essential. A background in modern drug discovery techniques, chemistry, and chemical biology is desirable.
The applicant must have a strong background in cancer biology, and experience with 2D and 3D cell culture techniques. Expertise in how genetic and epigenetic lesions alter the cellular stress response and apoptotic potential is preferred. The applicant will be expected to apply high-throughput screening technologies and must be comfortable developing, validating, and deploying biochemical and cell-based assays. The applicant is encouraged to harness the world class resources available at St. Jude to accelerate their research and seek new insights. The applicant is expected to work alongside other translational scientists, clinicians, and pharmacologists in a project team environment, with the end goal of contributing to the discovery of small molecules with the potential to treat pediatric cancers.
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
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