Postdoctoral Associate Position in Structural Biology
The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on in vitro biophysics studies of the role of liquid-liquid phase separation in the pathology of neurodegenerative diseases. Recent work (from our lab and others, see e.g., Molliex et al. Cell 163: 123-133, 2015) has revealed that phase separation can promote aggregation of RNA-binding proteins. Solid deposits of these proteins are the pathophysiological hallmark of ALS and related neurodegenerative diseases. The mechanism by which phase separation enhances aggregation or promotes dynamic arrest of dense phases is unclear and will be the focus of this project. Data will be interpreted through a polymer physics lense and supplemented through simulations via a collaboration with Dr. Rohit Papu’s laboratory at Washington University in St. Louis.
The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.
Tanja Mittag, PhD
Department of Structural Biology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
The successful candidate will use established methods for mapping phase diagrams and will take a leadership role in establishing methods to determine condensate material properties. The candidate will receive interdisciplinary training in phase separation and support with career development.
Given that the project will involve interdisciplinary research at the interface of biophysics, structural biology and polymer theory, with important implications for biological processes, the successful candidate should have a Ph.D. in in vitro structural biology or biophysics. The candidate should demonstrate an academic record of excellence, and a strong interest in the growing field of biomolecular condensates.