Postdoctoral Research Associate

Job Location US-TN-Memphis
ID
44170
Department
Structural Biology
Faculty Member
Roger Altman

Summary

St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine. The institution has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients.

 

The Department of Structural Biology is seeking a photochemist to help lead theoretical and design aspects of our ongoing fluorophore synthesis and photophysics research in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also help lead chemical biology initiatives aimed at advancing mechanistic studies of clinically important biological systems at the single-molecule scale. The lab’s highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.

 

Training opportunity and responsibilities

  • Photophysical characterizations (steady-state and time-resolved) of cyanine- and rhodamine-class organic fluorophores at both ensemble and single-molecule levels.
  • Electrochemical characterizations of cyanine- and rhodamine-class organic fluorophores.
  • Collaboratively designed quantum chemical calculations.
  • Mechanistic understanding of photophysics of cyanine- and rhodamine-class organic fluorophores.
  • Generate hypotheses-driven design strategies in collaboration with our chemistry team.
  • Presentation of experimental data and research progress in collaborative, cross-disciplinary settings.
  • Effectively communicate and help advance multidisciplinary team-based research projects.
  • Follow safety guidelines and contribute to the maintenance of spectroscopy equipment.

Minimum Education

  • Ph.D. in life sciences, chemical sciences or other physical science.

Minimum Experience

Advantageous skills and background

  • Experience in steady-state and time-resolved fluorescence (lifetime and anisotropy) measurements.
  • Experience in analysis and interpretation of laser-flash photolysis data.
  • Experience in electrochemical measurements (cyclic voltammetry).
  • Experience in quantum chemical (e.g. DFT/Gaussian) and molecular dynamics simulations in the Schrodinger software environment.
  • Basic knowledge of fluorescence and structure -performance relationships.
  • Research experience in cross-disciplinary, quantitative collaborative investigations.
  • Communication experience -both verbal and written – to diverse audiences.

EEO

St. Jude is an Equal Opportunity Employer

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