A post-doctoral fellowship position is available in the laboratory of Dr. Jeffery Klco in the Department of Pathology at St Jude Children’s Research Hospital to study the development of myeloid tumors in children. In particular, we are focused on the mechanisms of disease progression through the molecular characterization of different somatic and germline mutations in pediatric myeloid tumors, as well as the identification of vulnerabilities that may present unique therapeutic options. The experimental models include genetically-modified mice and the manipulation of primary hematopoietic cells, including cord blood CD34 cells and patient derived xenografts.
Experience in genomic technologies is strongly encouraged as these studies are supplemented with RNA-seq, including single cell RNA-seq, and a variety of targeted sequencing modalities and chromatin studies. The goal of these studies is to ultimately improve the outcome of children with AML and MDS through a better understanding of the disease pathogenesis.