Postdoctoral Research Associate - Chemical Biology & Therapeutic

Job Location US-TN-Memphis
Chemical Biology & Therapeutic
Faculty Member
Taosheng Chen


The Chen Lab studies the transcriptional regulation of nuclear receptors and fusion oncoproteins by using multidisciplinary approaches, while members of the High Throughput Bioscience (HTB) Center (directed by Dr. Chen) work together on target validation, assay development, and compound screening. We investigate signaling pathways and develop chemical probes to modulate transcription, with a goal to understand transcriptional regulation and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models.


The Chen Lab provides a unique training environment: in addition to basic research, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target validation, compound screening to preclinical mechanistic studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities, Senior Scientists in Pharmaceutical Companies, or Staff Scientists at St. Jude.


The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, structural biologists, and technologists. (


Taosheng Chen, PhD
Member (Professor), Department of Chemical Biology and Therapeutics

St. Jude Graduate School of Biomedical Sciences

Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-2794

Phone: 1-901-595-5937
Fax: 1-901-595-5715


The postdoctoral fellow will work on one or more of the following projects related to either nuclear receptors or fusion oncoproteins:

  • Investigate the mechanism of action of chemical probes (including bi-functional compounds such as protein degraders)
  • Perform structural studies and modeling of compound–protein interactions
  • Discover therapeutic targets by data mining followed by experimental validation
  • Design assays to discover small molecule modulators of transcription

Minimum Education

Highly motivated individuals with a strong publication record are encouraged to apply. The successful candidate will have a strong background in either cell/molecular biology or biochemistry/structural biology, experience in studying transcriptional regulation, and interest in investigating compound mechanism-of-action. Candidates must have (or soon receive) a PhD degree.

Other Information

COVID-19 vaccine:


As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.


EEO Statement:  St. Jude is an Equal Opportunity Employer

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