Postdoctoral Research Associate - Chemical Biology & Therapeutic

Job Location US-TN-Memphis
ID
43458
Department
Chemical Biology & Therapeutic
Faculty Member
Taosheng Chen

Summary

Postdoctoral Research Associate – Medicinal Chemist or Cell and Molecular Biologist

 

Overview

We are recruiting a Postdoctoral Research Associate (either a Medicinal Chemist or a Cell and Molecular Biologist) to join the efforts in chemically modulating transcription factors. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The medicinal chemistry or cell and molecular biology efforts are expected to synergize with our pharmacology and structural biology efforts and enable publication of impactful papers (e.g., Nat Commun 8:741, 2017; J Am Chem Soc 143:18467, 2021; Nucleic Acids Res 50:3254, 2022). We work closely with the High Throughput Bioscience (HTB) Center (directed by Dr. Chen) (https://www.stjude.org/research/departments/chemical-biology-therapeutics/high-throughput-biosciences.html) on target validation, assay development, and compound screening.

 

The Chen Lab provides a unique training environment: in addition to basic research, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target validation, chemical probe discovery and optimization to preclinical mechanistic studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities, Senior Scientists in Pharmaceutical Companies, or Staff Scientists at St. Jude.

 

Contact Information

Taosheng Chen, PhD
Member (Professor), Department of Chemical Biology and Therapeutics

Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-2794

Phone: 1-901-595-5937
Email: 
taosheng.chen@stjude.org
Website: 
https://www.stjude.org/chen

Responsibilities

  1. For a Medicinal Chemist: The postdoctoral fellow will independently design and synthesize compounds to modulate the function of nuclear receptors and drug-metabolizing enzymes, and collaboratively characterize their mechanisms of action (e.g., biochemical and cell-based assays, crystal structural studies and modeling of compound–protein interactions).
  2. For a Cell and Molecular Biologist: The postdoctoral fellow will investigate the mechanism of action of chemical probes (including protein degraders) that target PXR, CAR, CYP3A4, or CYP3A5; or the novel heterodimerization between PXR, CAR and other nuclear receptors.

Minimum Education

Highly motivated individuals with a strong publication record are encouraged to apply. Candidates must have (or soon receive) a PhD degree. (1) The successful medicinal chemistry candidate will have a strong background in medicinal chemistry. Experience in the following areas is a plus: in silico modeling of protein-ligand interaction; structure-guided compound design and optimization; design of bi-functional compounds (e.g., PROTACs); (2) The successful cell and molecular biology candidate will have a strong background in cell and molecular biology. Experience in studying transcriptional regulation and protein-protein interaction, is a plus.

Other Information

COVID-19 vaccine:

 

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

 

EEO Statement:  St. Jude is an Equal Opportunity Employer

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