Postdoctoral Research Assoc

Job Location US-TN-Memphis
ID
43425
Department
Structural Biology
Faculty Member
Scott Blanchard

Summary

St. Jude Children’s Research Hospital is seeking a highly motivated Post-Doctoral candidate to join the Department of Structural Biology and the laboratory of Dr. Scott Blanchard to drive interdisciplinary research initiatives in synthetic biology applied to the mechanism of protein synthesis. This work will be funded and carried out in the context of the National Science Foundation Center for Genetically Encoded Materials (http://gem-net.net/).

The Blanchard laboratory utilizes a range of quantitative biophysical and photophysical methods, as well as structural techniques, to explore clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, at the single-molecule scale. An additional focus of the lab is the development, synthesis, and characterization of photostabilized organic fluorophores, specifically suited for advancing the frontiers of biological imaging. These pursuits involve close collaboration with our state-of-the-art Single-Molecule Imaging Center, which operates several fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. Research within the Blanchard lab and C-GEM is highly interdisciplinary, collaborative, and team oriented. Candidates must be creative, and exhibit strong leadership skills. They must also be comfortable working within a diverse environment while pursuing highly impactful advances across a range of disciplines.

Experience with quantitative biophysical techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings are encouraged. This role involves protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Excellent communication skills, in particular the ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing to people of diverse scientific backgrounds is essential, as is a passion for learning and navigating new research fields.

 

Responsibilities:

  • Leadership position in research initiatives aiming to engineer the ribosome-catalyzed protein synthesis mechanism for the purpose of synthetic biology and material science applications. These efforts benefit from collaborative interactions with St. Jude’s Protein Technology Center, Center for Advanced Genome Engineering, as well as Cryo-EM, NMR, X-Ray and Mass-spectrometry centers.
  • Learn and utilize appropriate assays to answer specific biological questions.
  • Regularly present research plans and findings in a clear, concise manner to both general and specialized scientific audiences.
  • Prepare high-quality manuscripts for publication.

Assist in training and mentoring of graduate students, other post-docs and visiting scientists where necessary

 

Publication links:

Minimum Education

  • Ph.D. in life science, chemistry or other physical science.

EEO

St. Jude is an Equal Opportunity Employer

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