• Postdoctoral Research Associate

    Structural Biology
    Faculty Member
    Scott Blanchard
  • Summary

    St. Jude Children’s Research Hospital is seeking highly motivated candidates to join the Department of Structural Biology as a supported Postdoctoral Research Associate to drive new research directions in the Blanchard laboratory, including quantitative biophysical methods to explore clinically important biological systems at the single-molecule scale. Such pursuits will be carried out in collaboration with the Single-Molecule Imaging Center (SMC), which operates state-of-the-art fluorescence imaging technologies, including custom-built total internal reflection fluorescence (TIRF) and confocal time-correlated single-photon counting (TCSPC) microscopes. Our highly interdisciplinary, collaborative and mission-driven environment requires team-oriented individuals with strong leadership skills and the vision and creativity to successfully pursue scientific advances.


    • Assume leadership positions in one or more research directions to reveal the mechanistic underpinnings of clinically important biological systems, such as ribosome-catalyzed protein synthesis, membrane protein transport/signaling, and host-virus interactions, with a special emphasis on mammalian systems. These efforts will benefit from collaborative interactions with St. Jude’s protein technology and Cryo-EM/NMR and X-Ray Centers.
    • Be agile in learning and utilizing the most appropriate assays to answer the biological question at hand.
    • Utilize the cadre of single-molecule fluorescence instrumentation within the SMC – or help design and construct new instrumentation - to test hypotheses and rigorously quantify results, including model building and statistical analysis.
    • Regularly present research findings in a clear, concise manner to both general and specialized audiences.
    • Regularly prepare high-quality manuscripts of findings for publication.
    • Assist in training and mentoring graduate students, post-docs and visiting scientists.

    Required Credentials

    • Ph.D. in life science or other physical science.
    • Experience with quantitative biophysical and techniques, such as fluorescence imaging/spectroscopy, force spectroscopy, or single-channel electrophysiological recordings encouraged.
    • Practical experience with protein and/or nucleic acid biochemistry techniques, such as protein expression/purification/labeling and nucleic acid modification/manipulation/purification preferred.
    • Expert ability to distill and convey complex information in a clear and concise manner both verbally and in writing.


    St. Jude is an Equal Opportunity Employer

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