Jamy Peng's lab at St. Jude Children’s Research Hospital is looking for an enthusiastic postdoctoral trainee to investigate epigenetic mechanisms that regulate stem cell functions. Stem cells are responsible for originating and maintaining adult tissues in the human body. Over proliferation of stem cells can cause cancer, and under proliferation of stem cells leads to a variety of diseases such as tissue dystrophy and immuno-deficiency. Improved understanding of stem cell regulation will contribute to fundamental knowledge about human health and likely accelerate the progress of regenerative medicine.
We utilize human neural stem cells to understand how chromatin structure and gene expression programming underlie human neural development. Regulators of the modifications of lysine 27 in histone H3 (H3K27) are our focus because they are amongst the most recurrently mutated epigenetic modifiers in pediatric cancers. We generated preliminary findings to identify novel epigenetic mechanisms balancing the division and differentiation of human neural stem cells. These findings have strong implications for how dysfunction of H3K27 modifications lead to stem cell defects, contributing to neurodevelopmental defects and/or cancer. We are looking for a motivated individual to take over this project to the phase of manuscript preparation and expand this project to translational directions.
PhD with strong publication records and/or experience in mouse genetics and stem cell culturing.
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