• Postdoctoral Research Associate

    Job Location US-TN-Memphis
    ID
    42373
    Department
    Chemical Biology & Therapeutic
    Faculty Member
    Taosheng Chen
  • Summary

    The laboratory of Dr. Taosheng Chen studies the roles of nuclear xenobiotic receptors (PXR, CAR) and drug–metabolizing enzymes (CYP3A) in tumorigenesis and cancer drug resistance. We use multidisciplinary approaches to investigate signaling pathways, identify and validate targets, and develop chemical probes to interrogate the function of PXR, CAR and CYP3A in order to overcome drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).

    Responsibilities

    The postdoctoral fellow will work on one or more of the following projects:

    • Transcriptional and splicing regulation of PXR and CYP3A in human cancers;
    • Mechanism of action of chemical probes, including bi-functional compounds such as PROTACs;
    • Biophysical analysis and modeling of small molecule – protein interactions;
    • Signal cross-talk between drug metabolism and energy metabolism pathways;
    • Target discovery by data mining approaches followed by experimental validation.

     

    The Chen Lab provides a unique training environment: in addition to basic research on transcriptional/ post-transcriptional regulation, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target identification, compound screening to preclinical studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities or Senior Scientist in Pharmaceutical Companies.

     

    The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).

    Minimum Education

    Highly motivated individuals with a strong publication record are encouraged to apply. A strong interest in studying transcriptional/post-transcriptional regulation, together with experience either in cell and molecular biology, protein biochemistry and structural biology, molecular pharmacology, large-scale data mining or RNA biology, are desirable. Candidates must have (or soon receive) a PhD degree.

     

    Contact Information

    Taosheng Chen, PhD
    Member (Professor), Department of Chemical Biology and Therapeutics

    St. Jude Graduate School of Biomedical Sciences

    Director, High Throughput Bioscience Center
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-2794

    USA
    Phone: 1-901-595-5937
    Fax: 1-901-595-5715
    Email: 
    taosheng.chen@stjude.org
    Website: 
    http://www.stjuderesearch.org/chen/

    EEO

    St. Jude is an Equal Opportunity Employer

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