The Gottschalk Laboratory is seeking a highly motivated and creative candidate for a fully supported postdoctoral fellowship to develop immune-based therapies. Specifically, the research is aimed to combine T-cell-based therapies with oncolytic viruses for pediatric malignancies. Studies are focused on using genetic engineering approaches to not only render immune cells cancer specific, but also improve their effector function. Genetically modified immune cells in combination with oncolytic viruses will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. Ultimate goal of these studies are to translate these approaches into early Phase clinical testing.
Successful applicants will have a strong publication record, excellent communication skills, and a PhD or equivalent degree in molecular biology, cell biology, genetics, genomics, immunology, or a related field. To succeed in this position, you will have a strong immunology and cell biology background, with an emphasis on cellular immunology, and genetic manipulation of mammalian cells. Applicants with experience in generating and evaluating human immune cells, gene editing, or xenograft models including PDX models are strongly encouraged to apply.
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