A postdoctoral position is available to study mechanisms controlling autophagy in mammalian cells and tissues. Autophagy degrades dangerous or superfluous intracellular cargo via sequestration and delivery to the lysosome. Autophagy protects against tumor initiation, autoimmunity, and neurodegeneration but can also contribute to therapeutic resistance in advanced cancers. Our research is focused on the discovery, characterization, and pharmacological manipulation of regulatory systems that control cargo selection and the rate of autophagic flux. Our studies span the molecular, cellular, and organismal levels.
Applicants should have or expect a PhD degree at the time of application. Prior experience with biochemistry, signal transduction, or models of autophagy-relevant physiology or disease is preferred.
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