A postdoctoral position is available in Suzanne Baker’s laboratory in the Department of Developmental Neurobiology to study connections between development, epigenetics and cancer, focusing on pediatric high-grade gliomas as a model system. The Baker lab is a collaborative and interactive environment investigating the role of developmental context and cellular plasticity in cancer, and the role of epigenetic regulation in normal and tumorigenic development in brain. Our recent findings helped to define the unique genetic mutations in pediatric high-grade glioma (Wu et al, Nature Genetics 2012, 2014), and to show how epigenetic dysfunction induced by histone H3K27M mutations drives selective changes in gene expression and differentiation state (Larson et al, Cancer Cell 2019, Silveira et al, Acta Neuropath, 2019). Our research projects leverage patient tumors, in vivo model systems including genetically engineered mouse models and patient-derived xenografts, and in vitro model systems for mechanistic studies and integrated analyses of the genome, transcriptome and epigenome.
We are seeking highly motivated and collegial candidates with experience in molecular and cellular biology and biochemistry, along with epigenetics, mouse modeling, or developmental biology. Candidates should have or expect a PhD and/or MD degree. Interested applicants should send a cover letter describing research interests and accomplishments, CV and names and email addresses of three references to Suzanne.Baker@stjude.org and apply online.
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