The laboratory of Dr. Taosheng Chen studies the transcriptional regulation of nuclear receptors and drug–metabolizing enzymes and their roles in tumorigenesis and cancer drug resistance. We use large-scale approaches to investigate signaling pathways, identify and validate targets, develop novel chemical probes/therapeutic leads by using a multidisciplinary approach, and use them to interrogate the function of PXR, CAR and CYP3A in order to overcome drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).
The postdoctoral fellow will investigate the molecular mechanisms (transcription and/or alternative splicing) responsible for the aberrant expression of PXR and drug–metabolizing enzymes (e.g., CYP3A) in human cancers. The Chen Lab provides a unique training environment. In addition to basic research, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target identification, compound screening to preclinical studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities or Senior Scientist in Pharmaceutical Companies.
The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).
Highly motivated individuals with a strong publication record are encouraged to apply. Strong background in cell biology and molecular biology, and significant experience in transcriptional regulation and/or mRNA splicing are desirable. Candidates must have (or soon receive) a PhD degree.
Taosheng Chen, PhD
Member (Professor), Department of Chemical Biology and Therapeutics
St. Jude Graduate School of Biomedical Sciences
Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-2794
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.