• Postdoctoral Research Associate

    Job Location US-TN-Memphis
    Chemical Biology & Therapeutics
    Faculty Member
    Taosheng Chen
  • Summary

    The laboratory of Dr. Taosheng Chen studies the transcriptional regulation of nuclear receptors and drug–metabolizing enzymes and their roles in tumorigenesis and cancer drug resistance. We use large-scale approaches to investigate signaling pathways, identify and validate targets, develop novel chemical probes/therapeutic leads by using a multidisciplinary approach, and use them to interrogate the function of PXR, CAR and CYP3A in order to overcome drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).  


    The postdoctoral fellow will investigate the molecular mechanisms (transcription and/or alternative splicing) responsible for the aberrant expression of PXR and drug–metabolizing enzymes (e.g., CYP3A) in human cancers. The Chen Lab provides a unique training environment. In addition to basic research, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target identification, compound screening to preclinical studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities or Senior Scientist in Pharmaceutical Companies.  


    The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).

    Minimum Education

    Highly motivated individuals with a strong publication record are encouraged to apply. Strong background in cell biology and molecular biology, and significant experience in transcriptional regulation and/or mRNA splicing are desirable. Candidates must have (or soon receive) a PhD degree.


    Contact Information


    Taosheng Chen, PhD
    Member (Professor), Department of Chemical Biology and Therapeutics

    St. Jude Graduate School of Biomedical Sciences

    Director, High Throughput Bioscience Center
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-2794

    Phone: 1-901-595-5937
    Fax: 1-901-595-5715


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