A postdoctoral position is available in the laboratory of Dr. Daniel Savic to study pharmacogenomics in childhood acute lymphoblastic leukemia (ALL). The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of ALL in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and disease relapse. To address these critical questions, the Savic laboratory utilizes functional genomics (i.e. ChIP-seq, ATAC-seq, RNA-seq, Hi-C, etc.) and other high-throughput approaches to identify and functionally characterize noncoding regulatory elements (i.e. promoters, enhancers, insulators, etc.). The long-term goal of the Savic laboratory is to gain a better understanding of genomic mechanisms involved in chemotherapeutic drug resistance. A better understanding of drug resistance mechanisms offers a means of improving overall, as well as relapsed, ALL survival, and can further aid in the development of novel therapeutics that bypass or mitigate drug resistance mechanisms, and/or in the optimization of existing treatment regimens.
The candidate should have training in functional genomics and computational biology, as well as an excellent understanding of next-generation sequencing technology. Experience with R and a programming language (Perl or Python) is required. A strong background in statistical genetics and/or Bayesian statistics is also highly desirable.
Daniel Savic, PhD
Department of Pharmaceutical Sciences
St. Jude Children's Research Hospital
262 Danny Thomas Place, Room I-5103A
Memphis, TN 38105
ph 901 595 5346 fax 901 595 8869
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