A postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly interactive team studying the chromatin landscape of the childhood brain tumor medulloblastoma. As part of a Collaborative Research Project focused on Chromatin Regulation in Pediatric Cancer, the Northcott Lab is working with leaders in the fields of chromatin biology and pediatric cancer to understand how mutations in the chromatin machinery impact the epigenome to promote medulloblastoma development. We are using a combination of cutting-edge next-generation sequencing approaches (i.e. single-cell RNA-Seq, ATAC-seq, ChIP-seq) on large series of patient tumor samples and in vivo functional assays (i.e. CRISPR/Cas9 genome editing) in primary cells to better understand the role of chromatin deregulation in childhood cancer, especially medulloblastoma, the most common malignant pediatric brain tumor.
Experience in chromatin biology, developmental biology, or cancer biology, along with skills in biochemistry, molecular and cellular biology, genomics/epigenomics, and the use of primary cell cultures and/or in vivo model systems are highly desirable. Individuals having experience with transcriptional regulation and chromatin biology studies will be deemed highly competitive, as will those candidates with some degree of computational experience, although the latter is not a requirement.
The candidate shall have a strong background in cell and molecular biology, biochemistry, or related fields. Candidate must have a PhD, be highly motivated, have an excellent publication record, work well in a team environment, and possess strong communication and interpersonal skills.
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