• Postdoctoral Research Associate

    Job Location US-TN-Memphis
    Cell & Molecular Biology
    Faculty Member
    Joseph Opferman
  • Summary

    BCL-2 family members are well recognized regulators of programmed cell death and are responsible

    for regulating the homeostasis of tissues and defects in this pathway contribute to a variety of human

    diseases. Myeloid cell leukemia sequence 1 (MCL-1) is a unique anti-apoptotic molecule as its

    expression is highly regulated and it plays critical roles in promoting the survival of a myriad of cellular

    lineages. Recently, the Opferman laboratory revealed that in addition to its canonical role in

    antagonizing cell death that MCL-1 also promotes normal mitochondrial function in cells. These

    findings provide an attractive model for how both of MCL-1’s diverse functions may contribute to normal

    cell homeostasis and function. Additionally, MCL-1 is a highly amplified gene in human cancer leading

    to the possibility that both of these functional aspects may contribute to malignant cell growth and

    evasion of apoptosis. Therefore, the Opferman laboratory is taking a multidisciplinary approach to

    dissect mechanistically how these functions of MCL-1 are regulated and to understand how these

    functional roles of MCL-1 contribute to normal development and oncogenesis.


    This post-doctoral position is an ideal opportunity for enthusiastic candidates that have recently

    earned/expect to earn a PhD and/or MD, have experience in cell biology, molecular biology, and

    biochemical techniques. The strongest candidates will have demonstrated success in conducting

    original research as evidenced by peer-reviewed publications.


    St. Jude is an Equal Opportunity Employer

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