• CRISPR-Cas Genome Engineering Postdoctoral Fellowship

    Job Location US-TN-Memphis
    Faculty Member
    Shengdar Tsai
  • Summary

    The Laboratory of Dr. Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a fully supported postdoctoral fellowship in one of two areas: 1) to develop potentially curative CRISPR-Cas gene editing strategies in human hematopoietic stem cells for treatment of sickle cell disease and 2) to define safety of cancer immunotherapy genome editing targets in human T-cells.


    You will have the opportunity to lead new projects such as:

    • Optimizing pre-clinical CRISPR-Cas gene editing strategies for induction of fetal hemoglobin in red blood cell progeny of edited human hematopoietic stem and progenitor cells
    • Protein engineering of CRISPR-Cas nucleases for precise gene correction
    • Improving genomic methods to define and measure genome-wide activity of gene editing nucleases
    • Developing new strategies to understand the functional biological consequences of genome editing


    In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.

    Minimum Education

    Successful applicants will have a strong publication record, excellent communication skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, hematology, or a related area. To succeed in this position, you will have a strong molecular and cell biology background, with an emphasis on molecular cloning and genetic manipulation of mammalian cells. Applicants with experience with human hematopoietic stem cells or T-cells, genome editing, next-generation sequencing, or automated liquid handling are strongly encouraged to apply.


    Please direct inquiries to:

    Shengdar Tsai, Ph.D.




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