A Postdoctoral Research Fellow position is available in the laboratory of Dr. Clinton Stewart in the Department of Pharmaceutical Sciences at St. Jude Children’s Research Hospital. Our laboratory utilizes pharmacokinetic (PK) and pharmacodynamic (PD) modeling to address clinically relevant problems encountered in the therapy of children with brain tumors or solid malignancies. This position will give the applicant a comprehensive training experience that provides a foundation for the successful fellow to become an independent, laboratory-based clinical pharmaceutical scientist in either industry or academia.
Specifically, we apply pharmacometric approaches to results derived from preclinical and clinical studies to better understand the unique aspects of drug therapy for children with cancer, especially infants and very young children. Fellows have the opportunity to gain a breadth of experience including: translation of pre-clinical in vitro and in vivo data into clinical trials, modeling preclinical and clinical pharmacokinetic and pharmacodynamic data, and studying genetic determinants of interpatient variability in pharmacokinetics and pharmacodynamics.
A doctoral degree in an appropriate scientific field with a proficiency in pharmacokinetic and pharmacodynamic modeling and simulation methods including population approaches. A background in physiologically-based pharmacokinetics and/or systems pharmacology as well as experience with contemporary programming and modeling software (NONMEM and/or Monolix, R and/or Matlab) would be desirable.
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