• Postdoctoral Research Associate

    Job Location US-TN-Memphis
    Faculty Member
    Rhea Sumpter
  • Summary

    A postdoctoral researcher position is immediately available in Dr. Rhea Sumpter, Jr.’s laboratory at the Department of Immunology in St. Jude Children’s Research Hospital. Studies in Dr. Sumpter’s laboratory utilize innovative approaches and cutting-edge technologies to decipher the role of Fanconi anemia pathway proteins in selective autophagy, which is an ancient cell biology pathway that removes unwanted cytoplasmic constituents (e.g. intracellular pathogens, damaged organelles, protein aggregates) and delivers them to lysosomes for destruction. Defects in the autophagy pathway have been linked to numerous pathologies, including increased susceptibility to infectious and autoinflammatory diseases, cancer, metabolic disorders, and aging. We are focused on investigating the links between selective autophagy mediated by Fanconi anemia pathway proteins and host defense against viral infection, mitochondrial quality control, regulation of inflammasome signaling, bone marrow failure, and leukemogenesis. These studies will result in the discovery of the novel players and concepts that will deepen our understanding of the role of selective autophagy in health and disease, and may lead to new therapeutic targets for Fanconi anemia patients as well as for patients affected by the many other diseases in which the functioning of the autophagy pathway is impaired.

    Minimum Education

    Highly self-motivated candidates with Ph.D. or equivalent in immunology, microbiology, molecular biology, cell biology, as well as biochemistry are recommended to apply. Besides the unmatched benefit for postdoctoral fellows at St. Jude Children's Research Hospital, the extraordinary internal support and state-of-the-art facilities provide an exceptional environment to train the next generation of biomedical investigators. A cover letter of interest, CV and three recommendation letters should be sent to Rhea.Sumpter@STJUDE.ORG.


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