A postdoctoral fellowship is available in the laboratory of Dr. Charles Roberts in the Department of Oncology. Dr. Roberts’ lab studies the epigenetic regulation of gene expression. In particular we are studying chromatin-modifying proteins with a major focus on the SWI/SNF (BAF) chromatin remodeling/tumor suppressor complex and its relationship to cancers. Recent studies have revealed that genes encoding subunits of the SWI/SNF complex are mutated in over 20% of all cancers, a rate approaching that of p53, making this the most frequently mutated chromatin regulator in human malignancies. Research in the Roberts laboratory is designed to discover the mechanism by which SWI/SNF complex contributes to the regulation of gene expression and lineage specification, and the mechanisms by which mutation of the tumor suppressor subunits drives cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutation with the goal of identifying novel therapeutic opportunities. We seek an ambitious postdoctoral scientist with a strong background in molecular biology, cell biology, cancer biology, and/or genetics/epigenetics of tumorigenesis. Currently there are several projects ongoing in the laboratory involving the use of a variety of model systems that have been engineered in the lab including mouse models, primary cells, and cell lines as well as the use of large sequencing, CRISPR, and drug vulnerability data sets.
Candidates should have recently earned/expect to earn a Ph.D. and have published in peer-reviewed journals. A prerequisite is experience in basic methods of molecular biology and biochemistry.
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