The Peng Lab at St. Jude Children’s Research Hospital is looking for an enthusiastic postdoctoral trainee to investigate epigenetic mechanisms that regulate stem cell functions. Stem cells are responsible for originating and maintaining adult tissues in the human body. Over proliferation of stem cells can cause cancer, and under proliferation of stem cells leads to a variety of diseases such as tissue dystrophy, immuno-deficiency, and even death. Improved understanding of stem cell regulation will contribute to fundamental knowledge about human health and likely accelerate the progress of regenerative medicine.
We utilize human neural stem cells to understand how chromatin structure and gene expression programming promote human neural development. Regulators of the modifications of lysine 27 in histone H3 (H3K27) are our focus because they are amongst the most recurrently mutated epigenetic modifiers in pediatric cancers. We generated preliminary findings to identify novel epigenetic mechanisms balancing the division and differentiation of human neural stem cells. These findings have strong implications for how dysfunction of H3K27 modifications lead to stem cell defects, contributing to neurodevelopmental defects and/or cancer. We are looking for a motivated individual to take over this project to the phase of manuscript preparation and expand this project to translational directions.
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.