This postdoc position in the Department of Pharmaceutical Sciences is seeking a dedicated and motivated cancer researcher with a Ph.D. degree in the field of life science to investigate biological mechanisms driving metastasis of pediatric hepatoblastoma (HB) and hepatocellular carcinoma (HCC).
The metastatic forms of liver cancer are incurable and the efforts to develop more effective treatment have been hampered by the lack of relevant model systems that allow detailed biological understanding of the metastasis progress. Our lab recently established highly metastatic mouse models of both HB and HCC via an innovative 3D liver cancer spheroid-based approach. There are two projects we are looking for a motivated postdoc to take on: (1) we have identified a group of genes commonly dysregulated in the metastatic HB and HCC compared to their non-metastatic counterparts. We are interested in investigating their roles in regulating metastasis via both gene-orientated and CRISPR-based screening approaches; (2) we have observed significant tumor cell dissemination at both early and late stage of tumor development in the HB and HCC models. We are taking a single-cell RNA-seq approach to systematically characterize the molecular and cellular cascades of liver cancer metastasis by gene expression profiling of disseminated tumor cells at different metastasis stages and different anatomic locations.
A Ph.D degree in an appropriate life scientific field with training in mouse colony maintenance and primary cell culture. Experiences with high-throughput drug screen are preferred but not required.
About St. Jude
St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital’s mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.
Applications, including curriculum vitae, a brief research statement, and the names and contact information of three references, should be sent to:
Liqin Zhu, PhD
Department of Pharmaceutical Sciences
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105, USA
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