• Postdoctoral Research Associate

    Job Location US-TN-Memphis
    ID
    36317
    Department
    Chemical Biology & Therapeutics
    Faculty Member
    Taosheng Chen
  • Summary

    The laboratory of Dr. Taosheng Chen studies the roles of nuclear receptors PXR and CAR in regulating drug-induced liver toxicity, tumorigenesis, and cancer drug resistance. We develop novel chemical probes/therapeutic leads by using a multidisciplinary approach (biology, chemistry and structural biology), and use them to interrogate the function of PXR, CAR and CYP3A in order to overcome drug toxicity, drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).

    Responsibilities

    The postdoctoral fellow will work on one of the projects:

    (1) In vitro and in vivo validation of novel small molecule modulators of PXR and CAR in regulating drug metabolism, toxicity and resistance, and tumorigenesis (pharmacological approach);  

    (2) Regulation of PXR and CAR signaling pathways, including aberrant expression (by transcription and/or alternative splicing) and regulation of PXR and CYP3A in extrahepatic malignancy (multidisciplinary approach).

     

    The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).

    Minimum Education

    Highly motivated individuals (biologist or pharmacologist) with evidence of scientific accomplishment are encouraged to apply. Significant experience in one of the following areas is desirable: regulation of gene expression and/or splicing, using animal models to study small molecules, cell and molecular biology, or pharmacology. Candidates must have (or soon receive) a PhD or MD degree.

     

    Contact Information 

     

    Taosheng Chen, PhD

    Member (Professor), Department of Chemical Biology and Therapeutics

    St. Jude Graduate School of Biomedical Sciences

    Director, High Throughput Bioscience Center

    St. Jude Children's Research Hospital

    262 Danny Thomas Place

    Memphis, TN 38105-2794

    USA

    Phone: 1-901-595-5937

    Fax: 1-901-595-5715

    Email: taosheng.chen@stjude.org

    Website: http://www.stjuderesearch.org/chen/

    EEO

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