The laboratory of Dr. Taosheng Chen studies the roles of PXR and CAR (ligand-regulated transcription factors) in regulating drug-induced liver toxicity and cancer drug resistance. We develop novel chemical probes/therapeutic leads by using a multidisciplinary approach (biology, chemistry and structural biology), and use them to interrogate the function of PXR and CAR in order to overcome drug toxicity and drug resistance in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017. Doi: 10.1038/s41467-017-00780-5).
The postdoctoral fellow will work on one of the projects:
(1) Lead optimization of small molecule modulators of PXR and CAR (medicinal chemistry and structure-based approach);
(2) In vitro and in vivo validation of novel small molecule modulators of PXR and CAR in regulating drug metabolism, toxicity and resistance (Pharmacological approach);
(3) Regulation of PXR and CAR signaling pathways (multidisciplinary approach).
The successful candidate will employ conventional (e.g., cellular, molecular, biochemical, proteomic, structural, and chemical) as well as high-throughput (e.g., RNAi, CRISPR-Cas9, and chemical screens) approaches, and work in a collaborative and multidisciplinary environment (https://www.stjude.org/chen).
Highly motivated individuals (biologist, pharmacologist, medicinal chemist, or structure biologist) with evidence of scientific accomplishment are encouraged to apply. Significant experience in one of the following areas is desirable: cell and molecular biology, biochemistry, pharmacology, medicinal chemistry, or structural biology. Candidates must have (or soon receive) a PhD or MD degree.
Taosheng Chen, PhD
Member (Professor), Department of Chemical Biology and Therapeutics
St. Jude Graduate School of Biomedical Sciences
Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-2794