The laboratory of Dr. Taosheng Chen studies the roles of nuclear receptors PXR and CAR in regulating drug-induced liver toxicity, tumorigenesis, and cancer drug resistance. We develop novel chemical probes/therapeutic leads by using a multidisciplinary approach (biology, chemistry and structural biology), and use them to interrogate the function of PXR, CAR and CYP3A in order to overcome drug toxicity, drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).
The postdoctoral fellow will work on one of the projects:
(1) In vitro and in vivo validation of novel small molecule modulators of PXR and CAR in regulating drug metabolism, toxicity and resistance, and tumorigenesis (pharmacological approach);
(2) Regulation of PXR and CAR signaling pathways, including aberrant expression (by transcription and/or alternative splicing) and regulation of PXR and CYP3A in extrahepatic malignancy (multidisciplinary approach).
The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists and structural biologists (https://www.stjude.org/chen).
Highly motivated individuals (biologist or pharmacologist) with evidence of scientific accomplishment are encouraged to apply. Significant experience in one of the following areas is desirable: regulation of gene expression and/or splicing, using animal models to study small molecules, cell and molecular biology, or pharmacology. Candidates must have (or soon receive) a PhD or MD degree.
Taosheng Chen, PhD
Member (Professor), Department of Chemical Biology and Therapeutics
St. Jude Graduate School of Biomedical Sciences
Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-2794